A new individually addressable micro-LED array for photogenetic neural stimulation

IEEE Transactions on Biomedical Circuits and Systems

Volumn 4, Issue 6 PART 2, 2010, Pages 469-476

  McGovern, Brian ^a   Palmini, Rolando Berlinguer ^a   Grossman, Nir ^a   Drakakis, Emm Mic ^a   Poher, Vincent ^a   Neil, M A A ^a   Degenaar, Patrick ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Micro light emitting diode (LED); neural stimulation; optogenetic; retinal prosthesis

Indexed keywords

ACTIVE MATRIXES; EXCITATION PATTERN; MICRO-LED ARRAYS; NEURAL STIMULATIONS; OPTOGENETIC; PATCH CLAMP; RETINAL PROSTHESIS; SIMULTANEOUS CONTROL; SPATIOTEMPORAL CONTROL;

DIODES; ELECTROPHYSIOLOGY; LIGHT EMISSION; OPHTHALMOLOGY; PHYSICAL OPTICS; PROSTHETICS;

LIGHT EMITTING DIODES;

EID: 78649503549     PISSN: 19324545     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBCAS.2010.2081988     Document Type: Conference Paper

References (26)

1. V. Poher, N. Grossman, G. T. Kennedy, K. Nikolic, H. X. Zhang, Z. Gong, E. M. Drakakis, E. Gu, M. D. Dawson, P. M. W. French, P. Degenaar, and M. A. A. Neil, "Micro-LED arrays: A tool for two-dimensional neuron stimulation", J. Phys. D-Appl. Phys., vol. 41, no. 9, p. 9, 2008, 094014.
2. L. Golan, I. Reutsky, N. Farah, and S. Shoham, "Design and characteristics of holographic neural photo-stimulation systems", J. Neural. Eng., vol. 6, p. 14, 2009, 66004.
3. N. Farah, I. Reutsky, and S. Shoham, "Patterned optical activation of retinal ganglion cells", in Proc. IEEE Eng. Med. Biol. Soc. Conf., 2007, pp. 6369-6371.
4. G. Nagel, T. Szellas, W. Huhn, S. Kateriya, N. Adeishvili, P. Berthold, D. Ollig, P. Hegemann, and E. Bamberg, "Channelrhodopsin-2, a directly light-gated cation-selective membrane channel", Proc. Nat. Acad. Sci. United States Amer., vol. 100, pp. 13940-13945, 2003.
5. X. Han, X. Qian, J. G. Bernstein, H. H. Zhou, G. T. Franzesi, P. Stern, R. T. Bronson, A. M. Graybiel, R. Desimone, and E. Boyden, "Millisecond- timescale optical control of neural dynamics in the nonhuman primate brain", Neuron, vol. 62, pp. 191-198, 2009.
6. E. S. Boyden, F. Zhang, E. Bamberg, G. Nagel, and K. Deisseroth, "Millisecond-timescale, genetically targeted optical control of neural activity", Nature Neurosci., vol. 8, no. 9, pp. 1263-1268, 2005.
7. P. S. Lagali, D. Balya, G. B. Awatramani, T. A. Munch, D. S. Kim, V. Busskamp, C. L. Cepko, and B. Roska, "Light-activated channels targeted to on bipolar cells restore visual function in retinal degeneration", Nature Neurosci., vol. 11, pp. 667-675, 2008.
8. P. Degenaar, N. Grossman, M. A. Memon, J. Burrone, M. Dawson, E. Drakakis, M. Neil, and K. Nikolic, "Optobionic vision-a new genetically enhanced light on retinal prosthesis", J. Neural. Eng., vol. 6, p. 10, 2009, 035007.
9. F. Zhang, L.-P. Wang, E. S. Boyden, and K. Deisseroth, "Channelrhodopsin-2 and optical control of excitable cells", Nature Meth., vol. 3, no. 10, pp. 785-792, 2006.
10. G. Nagel, M. Brauner, J. F. Liewald, N. Adeishvili, E. Bamberg, and A. Gottschalk, "Light activation of channelrhodopsin-2 in excitable cells of caenorhabditis elegans triggers rapid behavioral responses", Curr. Biol., vol. 15, pp. 2279-2284, 2005.
11. X. Han, X. Qian, J. G. Bernstein, H.-H. Zhou, G. T. Franzesi, P. Stern, R. T. Bronson, A. M. Graybiel, R. Desimone, and E. S. Boyden, "Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain", Neuron, vol. 62, pp. 191-198, 2009.
12. A. R. Adamantidis, F. Zhang, A. M. Aravanis, K. Deisseroth, and L. de Lecea, "Neural substrates of awakening probed with optogenetic control of hypocretin neurons", Nature, vol. 450, pp. 420-424, 2007.
13. N. Grossman, V. Poher, M. S. Grubb, G. T. Kennedy, K. Nikolic, B. McGovern, R. B. Palmini, Z. Gong, E. Drakakis, M. A. A. Neil, M. D. Dawson, J. Burrone, and P. Degenaar, "Multi-site optical excitation using ChR2 and micro-LED array", J. Neural. Eng., vol. 7, p. 13, 2010, 016004.
14. S. X. Jin, J. Shakya, J. Y. Lin, and H. X. Jiang, "Size dependence of III-nitride microdisk light-emitting diode characteristics", Appl. Phys. Lett., vol. 78, pp. 3532-3534, 2001. (Pubitemid 33666816)
15. S. Lilley and J. Robbins, "The rat retinal ganglion cell in culture: An accessible CNS neurone", J. Pharmacol. Toxicol. Meth., vol. 51, no. 3, pp. 209-220, 2005.
16. L. Gunaydin, O. Yizharl, A. Berndt, V. Sohal, K. Deisseroth, and P. Hegemann, "Ultrafast optogenetic control", Nature Neurosci., vol. 13, pp. 387-393, 2010.
17. vol. 31, no. 2, pp. 158-159, 2006, Joint ISO/CIE standard-ISO 23539:2005 (e)/CIE s 010/e:2004, Color research and application,.
18. "Base unit definitions: Candela", The NIST Reference on Constants, Units, and Uncertainty. [Online]. Available: http://physics.nist.gov/ cuu/Units/candela.htm Retrieved 15/04/2010
19. B. R. Rae, C. Griffen, J. McKendry, J. M. Girkin, H. X. Zhang, E. Gu, D. Renshaw, E. Charbon, M. D. Dawson, and R. K. Henderson, "CMOS driven micro-pixel LEDs integrated with single photon avalanche diodes for time resolved fluorescence measurements", J. Phys. D: Appl. Phys., vol. 41, p. 6, 2008, 094011.
20. N. C. Das, M. Taysing-Lara, K. A. Olver, F. Kiamilev, J. P. Prineas, J. T. Olesberg, E. J. Koerperick, L. M. Murray, and T. F. Boggess, "Flip chip bonding of 68 × 68 MWIR LED arrays", IEEE Trans Electron. Packag. Manuf., vol. 32, no. 1, pp. 9-13, Jan. 2009.
21. A. V. Krishnamoorthy, K. W. Goossen, M. F. Chirovsky, R. G. Rozier, P. Chandramani, W. S. Hobson, S. P. Hui, J. Lopata, J. A. Walker, and L. A. D'Asaro, "16 × 16 VCSEL array flip-chip bonded to CMOS VLSI circuit", IEEE Photon. Technol. Lett., vol. 12, no. 8, pp. 1073-1075, Aug. 2000.
22. E. Culurciello and A. G. Andreou, "Capacitive inter-chip data and power transfer for 3-D VLSI", IEEE Trans. Circuits Syst. II, Expr. Briefs, vol. 53, no. 12, pp. 1348-1352, Dec. 2006.
23. E. F. Schubert, Light-Emitting Diodes, 2nd ed. Cambridge, U. K.: Cambridge Univ. Press, 2006.
24. H. X. Zhang, D. Massoubre, J. McKendry, Z. Gong, B. Guilhabert, C. Griffin, E. Gu, P. E. Jessop, J. M. Girkin, and M. D. Dawson, "Individually-addressable flip-chip AlInGaN micropixelated light emitting diode arrays with high continuous and nanosecond output power", Opt. Expr., vol. 16, no. 13, p. 9, 2008, 9918.
25. N. Grossman, K. Nikolic, V. Poher, B. McGovern, E. Drakakis, M. Neil, C. Toumazou, and P. Degenaar, "Photostimulator for optogenetic retinal prosthesis", in Proc. 4th Int. IEEE Eng. Med. Biol. Soc. Conf. Neural Eng., 2009, pp. 68-71.
26. Z. Y. Fan, J. Y. Lin, and H. X. Jiang, "III-nitride micro-emitter arrays: Development and applications", J. Phys. D: Appl. Phys., vol. 41, no. 9, p. 12, 2008, 094001.