Immunomodulatory effects of betulinic acid from the bark of white birch on mice

Journal of Veterinary Science

Volumn 11, Issue 4, 2010, Pages 305-313

  Yi, Jin E ^a   Obminska Mrukowicz, Bozena ^b   Yuan, Li Yun ^a   Yuan, Hui ^a  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

^b WROCLAW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

Betulinic acid; Cytokine; Immunomodulation; Macrophage; T cell subpopulation

Indexed keywords

BETULA PENDULA; MUS;

BETULIC ACID; CYTOKINE; IMMUNOLOGIC FACTOR; TRITERPENE;

ADAPTIVE IMMUNITY; ANIMAL; ARTICLE; BIRCH; BLOOD; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FEMALE; INNATE IMMUNITY; MACROPHAGE; MOUSE; PHAGOCYTOSIS; RANDOMIZATION; SPLEEN; THYMUS;

ADAPTIVE IMMUNITY; ANIMALS; BETULA; CELL PROLIFERATION; CYTOKINES; FEMALE; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; MACROPHAGES; MICE; PHAGOCYTOSIS; RANDOM ALLOCATION; SPLEEN; THYMUS GLAND; TRITERPENES;

EID: 78649486619     PISSN: 1229845X     EISSN: None     Source Type: Journal    
DOI: 10.4142/jvs.2010.11.4.305     Document Type: Article

References (31)

1. Adler FL. Studies on mouse antibodies. II. Mercaptoethanolsensitive 7 S antibodies in mouse antisera to protein antigens. J Immunol 1965, 95, 39-47.
2. Alakurtti S, Mäkelä T, Koskimies S, Yli-Kauhaluoma J. Pharmacological properties of the ubiquitous natural product betulin. Eur J Pharm Sci 2006, 29, 1-13.
3. Al-Daccak R, Mooney N, Charron D. MHC class II signaling in antigen-presenting cells. Curr Opin Immunol 2004, 16, 108-113.
4. Amat N, Upur H, Ablimit A, Matsidik A, Yusup A, Kijjoa A. Immunomodulatory effects of Abnormal Savda Munsiq, a traditional Uighur medicine, on the combined stress mice. J Ethnopharmacol 2009, 122, 42-47.
5. 2 inhibitors. Phytochemistry 2001, 58, 865-874.
6. Bringmann G, Saeb W, Assi LA, François G, Sankara Narayanan AS, Peters K, Peters EM. Betulinic acid: isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester. Planta Med 1997, 63, 255-257.
7. Chang CW, Wu TS, Hsieh YS, Kuo SC, Chao PD. Terpenoids of Syzygium formosanum. J Nat Prod 1999, 62, 327-328.
8. + T cell responses: The alternative approaches. Annu Rev Immunol 1997, 15, 297-322.
9. Dhur A, Galan P, Preziosi P, Hercberg S. Lymphocyte subpopulations in the thymus, lymph nodes and spleen of iron-deficient and rehabilitated mice. J Nutr 1991, 121, 1418-1424.
10. Enwerem NM, Okogun JI, Wambebe CO, Okorie DA, Akah PA. Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid. Phytomedicine 2001, 8, 112-114.
11. Esper RJ, Nordaby RA, Vilariño JO, Paragano A, Cacharrón JL, Machado RA. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc Diabetol 2006, 5, 4.
12. Flekhter OB, Nigmatullina LR, Baltina LA, Karachurina LT, Galin FZ, Zarudii FS, Tolstikov GA, Boreko EI, Pavlova NI, Nikolaeva SN, Savinova OV. Synthesis of betulinic acid from betulin extract and study of the antiviral and antiulcer activity of some related terpenoids. Pharm Chem J 2002, 36, 484-487.
13. Fujioka T, Kashiwada Y, Kilkuskie RE, Cosentino LM, Ballas LM, Jiang JB, Janzen WP, Chen IS, Lee KH. Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod 1994, 57, 243-247.
14. Gautam M, Saha S, Bani S, Kaul A, Mishra S, Patil D, Satti NK, Suri KA, Gairola S, Suresh K, Jadhav S, Qazi GN, Patwardhan B. Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: implications for immunoadjuvant potential. J Ethnopharmacol 2009, 121, 241-247.
15. Higa M, Noha N, Yokaryo H, Ogihara K, Yogi S. Three new naphthoquinone derivatives from Diospyros maritima Blume. Chem Pharm Bull (Tokyo) 2002, 50, 590-593.
16. Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 2001, 15, 43-58.
17. Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 2003, 149, 1-38.
18. Kovalenko LP, Balakshin VV, Presnova GA, Chistyakov AN, Shipaeva EV, Alekseeva SV, Durnev AD. Immunotoxicity and allergenic properties of betulincontaining birch bark dry extract. Pharm Chem J 2007, 41, 17-19.
19. Ma MS, Bae IY, Lee HG, Yang CB. Purification and identification of angiotensin I-converting enzyme inhibitory peptide from buckwheat (Fagopyrum esculentum Moench). Food Chem 2006, 96, 36-42.
20. Meisel H. Food-derived bioactive proteins and peptides as potential components of nutraceuticals. Curr Pharm Des 2007, 13, 873-874.
21. O'Garra A, Murphy K. Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol 1994, 6, 458-466.
22. Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH, Kinghorn AD, Brown DM, Wani MC, Wall ME, Hieken TJ, Das Gupta TK, Pezzuto JM. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1995, 1, 1046-1051.
23. Pokrovskii AG, Shintyapina AB, Pronkina NV, Kozhevnikov VS, Plyasunova OA, Shul'ts EE, Tolstikov GA. Activation of apoptosis by derivatives of betulinic acid in human tumor cells in vitro. Dokl Biochem Biophys 2006, 407, 94-97.
24. Recio MC, Giner RM, Máñez S, Gueho J, Julien HR, Hostettmann K, Ríos JL. Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta Med 1995, 61, 9-12.
25. Schühly W, Heilmann J, Calis I, Sticher O. New triterpenoids with antibacterial activity from Zizyphus joazeiro. Planta Med 1999, 65, 740-743.
26. Scheller J, Ohnesorge N, Rose-John S. Interleukin-6 trans-signalling in chronic inflammation and cancer. Scand J Immunol 2006, 63, 321-329.
27. Takahashi M, Moriguchi S, Yoshikawa M, Sasaki R. Isolation and characterization of oryzatensin: A novel bioactive peptide with ileum-contracting and immunomodulating activities derived from rice albumin. Biochem Mol Biol Int 1994, 33, 1151-1158.
28. Yamauchi F, Suetsuna K. Immunological effects of dietary peptide derived from soybean protein. J Nutr Biochem 1993, 4, 450-457.
29. Yang R, Zhang Z, Pei X, Han X, Wang J, Wang L, Long Z, Shen X, Li Y. Immunomodulatory effects of marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) in mice. Food Chem 2009, 113, 464-470.
30. Yun Y, Han S, Park E, Yim D, Lee S, Lee CK, Cho K, Kim K. Immunomodulatory activity of betulinic acid by producing pro-inflammatory cytokines and activation of macrophages. Arch Pharm Res 2003, 26, 1087-1095.
31. Zdzisińska B, Rzeski W, Paduch R, Szuster-Ciesielska A, Kaczor J, Wejksza K, Kandefer-Szerszeń M. Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures. Pol J Pharmacol 2003, 55, 235-238.