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There are currently no POCT devices to monitor low molecular weight heparin. This study suggests that the R and TDR parameters on the TEG can be used to assess therapeutic anti-Xa levels
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Artang R, Frandsen NJ, Nielsen JD. Application of basic and composite thrombelastography parameters in monitoring of the antithrombotic effect of the low molecular weight heparin dalteparin: An in vivo study. Thromb J 2009; 7:1-7. There are currently no POCT devices to monitor low molecular weight heparin. This study suggests that the R and TDR parameters on the TEG can be used to assess therapeutic anti-Xa levels.
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A common practice for TEG usage is to mix blood with citrate to prevent premature clot formation before the sample can be processed. This study argues that the TEG with noncitrated blood is more accurate than one with citrated blood
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There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals
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Moerenhout CM, Claeys MJ, Haine S, et al. Clinical relevance of clopidogrel unresponsiveness during elective coronary stenting: Experience with the point-of-care platelet function assay-100C/ADP. Am Heart J 2010; 159:434-438. There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals.
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26
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There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals
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Schuhmann CG, Sohn HY, Nagel J, et al. Clinical management of clopidogrel inefficiency by point of care platelet function testing and individual adjustment of antiplatelet therapy: Initial experiences. Platelets 2009; 20:498-504. There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals.
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Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
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There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals
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Sibbing D, Braun S, Morath T, et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol 2009; 53:849-856. There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals.
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J Am Coll Cardiol
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Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009; 360:363-375.
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67849117309
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Prevalence of aspirin and clopidogrel resistance among patients with and without drug-eluting stent thrombosis
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There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals
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Pinto Slottow TL, Bonello L, Gavini R, et al. Prevalence of aspirin and clopidogrel resistance among patients with and without drug-eluting stent thrombosis. Am J Cardiol 2009; 104:525-530. There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals.
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There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals
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Boncoraglioa GB, Bodinib A, Brambillab C, et al. Aspirin resistance determined with PFA-100 does not predict new thrombotic events in patients with stable ischemic cerebrovascular disease. Clin Neurol Neurosurg 2009; 111:270-273. There has been a recent trend towards using POCT to evaluate therapeutic effectiveness of anticoagulants. These series of studies may reduce the number of adverse coronary events by better ensuring the attainment of appropriate anticoagulation goals.
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Uneventful removal of an epidural catheter guided by impedance aggregometry in a patient with recent coronary stenting and treated with clopidogrel and acetylsalicylic acid
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Bergmann L. Uneventful removal of an epidural catheter guided by impedance aggregometry in a patient with recent coronary stenting and treated with clopidogrel and acetylsalicylic acid. Reg Anesth Pain Med 2007; 32:354-357.
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Use of error grid analysis to evaluate acceptability of a point of care prothrombin time meter
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Peterson JR, Vonmarensdorf HM, Weiss HL, Elghetany MT. Use of error grid analysis to evaluate acceptability of a point of care prothrombin time meter. Clin Chim Acta 2010; 411:131-134.
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42
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67749117937
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Point-of-care monitoring of oral anticoagulation therapy in children. Comparison of the CoaguChek XS system with venous INR and venous INR using an International Reference Thromboplastin preparation (rTF/95)
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71549163456
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Does point of care prothrombin time measurement reduce the transfusion of fresh frozen plasma in patients undergoing major surgery? The POC-OP randomized-controlled trial
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An important application of POCT is to reduce unnecessary transfusion. This study suggests that the use of POCT decreases unnecessary fresh frozen plasma transfusion
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Urwyler N, Trelle S, Theiler L, et al. Does point of care prothrombin time measurement reduce the transfusion of fresh frozen plasma in patients undergoing major surgery? The POC-OP randomized-controlled trial. Thromb Haemost 2009; 10:1-9. An important application of POCT is to reduce unnecessary transfusion. This study suggests that the use of POCT decreases unnecessary fresh frozen plasma transfusion.
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Hoel RW, Albright RC, Beyer LK, et al. Correlation of point-of-care international normalized ratio to laboratory international normalized ratio in hemodialysis patients taking warfarin. Clin J Am Soc Nephrol 2009; 4:99-104.
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45
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67649216544
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Point-of-care coagulation monitors calibrated for the international normalized ratio for cirrhosis (INRliver) can help to implement of INRliver for the calculation of the MELD score
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This study showed the POCT can be used to determine MELD score for liver transplant patients in an easier, standardized way compared to the current WHO standard of thromboplastin measurement
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Tripodi A, Chantarangkul V, Primignani M, et al. Point-of-care coagulation monitors calibrated for the international normalized ratio for cirrhosis (INRliver) can help to implement of INRliver for the calculation of the MELD score. J Hepatol 2009; 51:288-295. This study showed the POCT can be used to determine MELD score for liver transplant patients in an easier, standardized way compared to the current WHO standard of thromboplastin measurement.
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Evaluation of point-of-care activated partial thromboplastin time testing by comparison to laboratory-based assay for control of intravenous heparin
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Douglas AD, Jefferis J, Sharma R, et al. Evaluation of point-of-care activated partial thromboplastin time testing by comparison to laboratory-based assay for control of intravenous heparin. Angiology 2009; 60:358-361.
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This study argued that intensive insulin therapy, a widely accepted glucose management strategy, was harmful to patients. It has shifted the practice of glycemic control by many to a more conservative approach
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Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283-1297. This study argued that intensive insulin therapy, a widely accepted glucose management strategy, was harmful to patients. It has shifted the practice of glycemic control by many to a more conservative approach.
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50
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Comparison of glucose point-of-care values with laboratory values in critically ill patients
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This study suggests that POCT and laboratory glucose testing differ to the extent that it may alter therapeutic plans
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Shearer A, Boehmer M, Closs M, et al. Comparison of glucose point-of-care values with laboratory values in critically ill patients. Am J Crit Care 2009; 18:224-230. This study suggests that POCT and laboratory glucose testing differ to the extent that it may alter therapeutic plans.
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Am J Crit Care
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