The risk of false results in the assessment of platelet function in the absence of antiplatelet medication: Comparision of the PFA-100, multiplate electrical impedance aggregometry and verify now assays

Thrombosis Research

Volumn 125, Issue 4, 2010, Pages

  Can, Mehmet Mustafa ^a   Tanboǧa, Ibrahim Halil ^a   Türkyilmaz, Erdem ^a   Karabay, Can Yucel ^a   Akgun, Taylan ^a   Koca, Fatih ^a   Tokgoz, Hacer Ceren ^a   Keles, Nursen ^a   Ozkan, Alper ^a   Bezgin, Tahir ^a   Ozveren, Olcay ^b   Sonmez, Kenan ^a   Saǧlam, Mustafa ^a   Ozdemir, Nihal ^a   Kaymaz, Cihangir ^a  

^a KOSUYOLU HEART AND RESEARCH HOSPITAL   (Turkey)

^b DUMLUPINAR UNIVERSITY   (Turkey)

Author keywords

Baseline platelet activity; Platelet function tests

Indexed keywords

ACETYLSALICYLIC ACID;

ADULT; ANALYZER; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; COLLAGEN EPINEPHRINE CLOSURE TIME TEST; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; HUMAN; IMPEDANCE; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTIPLATE ELECTRICAL IMPEDANCE AGGREGOMETRY; PRIORITY JOURNAL; RELIABILITY; RISK ASSESSMENT; RISK FACTOR; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS PREVENTION; VALIDITY; VERIFY NOW ASPIRIN TEST;

ASPIRIN; BIOLOGICAL ASSAY; BLOOD PLATELETS; COLLAGEN; ELECTRIC IMPEDANCE; EPINEPHRINE; HEMOSTASIS; HUMANS; LABORATORY TECHNIQUES AND PROCEDURES; PLATELET AGGREGATION; PLATELET COUNT; PLATELET FUNCTION TESTS; RISK; RISK FACTORS;

EID: 77949567387     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2009.11.005     Document Type: Article

References (35)

1. Patrono C., Coller B., FitzGerald G.A., Hirsh J., and Roth G. Platelet active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (2004) 234S-264S
2. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86.
3. Maree A.O., and Fitzgerald D.J. Aspirin and coronary artery disease. Thromb Haemost 92 (2004) 1175-1181
4. Chakroun T., Addad F., Abderazek F., Ben-Farhat M., Hamdi S., Gamra H., et al. Screening for aspirin resistance in stable coronary artery patients by three different tests. Thromb Res 121 (2007) 413-418
5. Gum P.A., Kottke-Marchant K., Poggio E.D., Gurm H., Welsh P.A., Brooks L., et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease. Am J Cardiol 88 (2001) 230-235
6. Szczeklik A., Musial J., Undas A., and Sanak M. Aspirin resistance. J Thromb Haemost 3 (2005) 1655-1662
7. Michelson A.D., Cattaneo M., Eikelboom J.W., Gurbel P., Kottke-Marchant K., Kunicki T.J., et al. Aspirin resistance:position paper of the Working Group on Aspirin Resistance. J Thromb Haemost 3 (2005) 1309-1311
8. Mortensen J., Poulsen T.S., Grove E.L., Refsgaard J., Nielsen H.L., Pedersen S.B., et al. Monitoring aspirin therapy with the Platelet Function Analyzer-100. Scand J Clin Lab Invest (2008) 1-7
9. Madsen E.H., Schmidt E.B., Maurer-Spurej E., and Kristensen S.R. Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100. Platelets 19 (2008) 335-341
10. Nielsen H.L., Kristensen S.D., Thygesen S.S., Mortensen J., Pedersen S.B., Grove E.L., et al. Aspirin response evaluated by the VerifyNowtrade mark Aspirin System and Light Transmission Aggregometry. Thromb Res 123 (2008) 267-273
11. Gasparyan A.Y., Watson T., and Lip G.Y. The role of aspirin in cardiovascular prevention: implications of aspirin resistance. J Am Coll Cardiol 51 (2008) 1829-1843
12. Serebruany V.L., Eisert C., Atar D., and Ferguson J.J. Antiplatelet 'resistance' and 'non-responders': what do these terms really mean?. Fundam Clin Pharmacol 23 1 (2009) 11-18
13. Glenn R., White A.E., Johnson A., Fox S.C., Behan M.W., Dolan G., et al. Leukocyte count and leukocyte ecto-nucleotidase are major determinants of the effects of adenosine triphosphate and adenosine diphosphate on platelet aggregation in human blood. Platelets 16 (2005) 159-170
14. Harrison P., Segal H., Blasbery K., Furtado C., Silver L., and Rothwell P.M. Screening for aspirin responsiveness after transient ischemic attack and stroke: comparison of 2 point-of-care platelet function tests with optical aggregometry. Stroke 36 (2005) 1001-1005
15. Crescente M., Di Castelnuovo A., Iacoviello L., Vermylen J., Cerletti C., and de Gaetano G. Response variability to aspirin as assessed by the platelet function analyzer (PFA)-100. A systematic review. Thromb Haemost 99 1 (2008) 14-26
16. Dyszkiewicz-Korpanty A.M., Kim A., Burner J.D., Frenkel E.P., and Sarode R. Comparison of a rapid platelet function assay -Verify Now™ Aspirin - with whole blood impedance aggregometry for the detection of aspirin resistance. Thromb Res 120 (2007) 485-488
17. Chen W.H., Lee P.Y., Ng W., Tse H.F., and Lau C.P. Aspirin resistance is associated with a high incidence of myonecrosis after nonurgent percutaneous coronary intervention despite clopidogrel pretreatment. J Am Coll Cardiol 43 6 (2004) 1122-1126
18. Gum P.A., Kottke-Marchant K., Welsh P.A., White J., and Topol E.J. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol 41 (2003) 961-965
19. Dyszkiewicz-Korpanty A.M., Frenkel E.P., and Sarode R. Approach to the assessment of platelet function: comparison between optical-based platelet-rich plasma and impedance-based whole blood platelet aggregation methods. Clin Appl Thromb Hemost 11 (2005) 25-35
20. Michelson A.D., Frelinger III A.L., and Furman M.I. Current options in platelet function testing. Am J Cardiol 98 Suppl 1 (2006) S4-S10
21. Michelson A.D. Platelet function testing in cardiovascular diseases. Circulation 110 (2004) 489-493
22. Frelinger III A.L., Furman M.I., Linden M.D., Li Y., Fox M.L., Barnard M.R., et al. Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance. Circulation 113 (2006) 2888-2896
23. Mammen E.F., Comp P.C., Gosselin R., Greenberg C., Hoots W.K., Kessler C.M., et al. PFA-100 system: a new method for assessment of platelet dysfunction. Semin Thromb Hemost 24 (1998) 195-202
24. Harrison P. Platelet function analysis. Blood Rev 19 (2005) 111-123
25. Homoncik M., Jilma B., Hergovich N., Stohlawetz P., Panzer S., and Speiser W. Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100. Thromb Haemost 83 (2000) 316-321
26. Malinin A., Spergling M., Muhlestein B., Steinhubl S., and Serebruany V. Assessing aspirin responsiveness in subjects with multiple risk factors for vascular disease with a rapid platelet function analyzer. Blood Coagul Fibrinolysis 15 (2004) 295-301
27. Michelson A.D. Methods for the Measurement of Platelet Function. Am J Cardiol 103 3 (February 2 2009) 20A-26A Supplement 1
28. Steinhubl S.R. The VerifyNow system. In: Michelson A.D. (Ed). Platelets. 2nd ed. (2007), Elsevier/Academic Press, San Diego 509-518
29. Harrison P., Frelinger III A.L., Furman M.I., and Michelson A.D. Measuring antiplatelet drug effects in the laboratory. Thromb Res 120 (2007) 323-336
30. Görlinger K., Jambor C., Dirkmann D., Dusse F., Hanke A., Adamzik M., et al. Platelet Function Analysis with Point-of-Care Methods. Herz 33 4 (2008) 297-305
31. Calatzis A., Wittwer M., and Krueger B. A new approach to platelet function analysis in whole blood - The Multiplate Analyzer. Platelets 15 8 (2004) 485-486
32. Toth O., Calatzis A., Penz S., Losonczy H., and Siess W. Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost 96 6 (2006) 781-788
33. von Pape K.W., Dzijan-Horn M., Bohner J., Spannagl M., Weisser H., and Calatzis A. Control of aspirin effect in chronic cardiovascular patients using two whole blood platelet function assays. PFA-100 and Multiplate. Hamostaseologie 27 3 (2007) 155-160
34. Heilmann E.J., Kundu S.K., Sio R., Garcia C., Gomez R., and Christie D.J. Comparison of four commercial citrate blood collection systems for platelet function analysis by the PFA-100 system. Thromb Res 87 (1997) 159-164
35. Mann K.G., Whelihan M.F., Butenas S., and Orfeo T. Citrate anticoagulation and the dynamics of thrombin generation. Thromb Haemost 5 10 (2007) 2055-2061