Norepinephrine induces systolic failure and inhibits antiapoptotic genes in a polymicrobial septic rat model

Life Sciences

Volumn 87, Issue 23-26, 2010, Pages 672-678

  Chopra, Mani ^a   Das, Padmalaya ^a   Golden, Honey ^c   Dostal, David E ^c   Watson, Linley E ^d   Sharma, Avadhesh C ^a,b  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

^b PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^d SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

Birc1b; Echocardiography; Ejection fraction; Fractional shortening; Heart; Left ventricle; SuperArray

Indexed keywords

BETA ACTIN; CASPASE; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CD40 ANTIGEN; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE 1; IMMUNOGLOBULIN; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 10; NEURONAL APOPTOSIS INHIBITORY PROTEIN; NORADRENALIN; PROTEIN BCL 2; PROTEIN P53; RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CECUM; COMPETITIVE INHIBITION; CONTINUOUS INFUSION; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DISEASE COURSE; DOWN REGULATION; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART DISEASE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART OUTPUT; HEART RATE; HOUSEKEEPING GENE; INOCULATION; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; POLYMICROBIAL SEPSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SEPSIS; SHAM PROCEDURE; SPRAGUE DAWLEY RAT; SYSTOLIC DYSFUNCTION; UPREGULATION;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ECHOCARDIOGRAPHY; INTERLEUKIN-10; MALE; NOREPINEPHRINE; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VASOCONSTRICTOR AGENTS; VENTRICULAR DYSFUNCTION;

ANIMALIA; RATTUS;

EID: 78649448059     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.09.029     Document Type: Article

References (36)

1. Aronson C.E., Hanno E.R. Effects of ketamine on the isolated perfused rat heart. Gen Pharmacol 1978, 9(4):249-255.
2. Brahmbhatt S., Gupta A., Sharma A.C. Bigendothelin-1 (1-21) fragment during early sepsis modulates tau, p38-MAPK phosphorylation and nitric oxide synthase activation. Mol Cell Biochem 2005, 271:225-237.
3. Brown A.S., Calachanis M., Evdoridis C., Hancock J., Wild S., Prasan A., et al. Sonovue improves endocardial border detection and variability in assessing wall motion score and ejection fraction during stress echocardiography. Ir J Med Sci 2004, 173(1):13-17.
4. Charpentier J., Luyt C.E., Fulla Y., Vinsonneau C., Cariou A., Grabar S., et al. Brain natriuretic peptide: a marker of myocardial dysfunction and prognosis during severe sepsis. Crit Care Med 2004, 32:660-665.
5. Chopra M., Sharma A.C. Distinct cardiodynamic and molecular characteristics during early and late stages of sepsis-induced myocardial dysfunction. Life Sci 2007, 81:306-316.
6. Chopra M., Sharma A.C. Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heart. Pharmacol Res 2009, 60:303-313.
7. Chopra M., Das P., Sharma A.C. Caspase-3 knock-down reverses contractile dysfunction induced by sepsis in adult rat ventricular myocytes. Br J Pharmacol 2010, 160(1):93-100.
8. Colucci W.S., Sawyer D.B., Singh K., Communal C. Adrenergic overload and apoptosis in heart failure: implications for therapy. J Card Fail 2000, 6:1-7.
9. Debaene B., Goldfarb G., Braillon A., Jolis P., Lebrec D. Effects of ketamine, halothane, enflurane, and isoflurane on systemic and splanchnic hemodynamics in normovolemic and hypovolemic cirrhotic rats. Anesthesiology 1990, 73(1):118-124.
10. Dellinger R.P., Levy M.M., Carlet J.M., Bion J., Parker M.M., Jaeschke R., et al. Surviving Sepsis Campaign: International Guidelines For Management Of Severe Sepsis And Septic Shock: 2008. Intensive Care Med 2008, 34:17-60.
11. Fernandes C.J., Akamine N., Knobel E. Cardiac troponin: a new serum marker of myocardial injury in sepsis. Intensive Care Med 1999, 25:1165-1168.
12. Gibot S., Lévy B., Nevière R., Cariou A., Lesur O. Myocardial dysfunction and septic shock. Med Sci (Paris) 2004, 20:1115-1118.
13. Gupta A., Sharma A.C. Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases. Mol Cell Biochem 2004, 265:47-56.
14. Gupta A., Aberle N.S., Kapoor R., Ren J., Sharma A.C. Bigendothelin-1 via p38-MAPK-dependent mechanism regulates adult rat ventricular myocyte contractility in sepsis. Biochim Biophys Acta 2005, 1741:127-139.
15. Gupta A., Aberle N.S., Ren J., Sharma A.C. Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and apoptosis during sepsis. J Mol Cell Cardiol 2005, 38(3):527-537.
16. Hu B.H., Cai Q., Manohar S., Jiang H., Ding D., Coling D.E., et al. Differential expression of apoptosis-related genes in the cochlea of noise-exposed rats. Neuroscience 2009, 161(3):915-925.
17. Jacobs W.B., Govoni G., Ho D., Atwal J.K., Barnabe-Heider F., Keyes W.M., et al. p63 is an essential proapoptotic protein during neural development. Neuron 2005, 48:743-756.
18. Krishnagopalan S., Kumar A., Parrillo J.E., Kumar A. Myocardial dysfunction in the patient with sepsis. Curr Opin Crit Care 2002, 8:376-388.
19. Kumar A., Haery C., Parrillo J.E. Myocardial dysfunction in septic shock. Crit Care Clin 2000, 6:251-287.
20. Levy R.J., Piel D.A., Acton P.D., Zhou R., Ferrari V.A., Karp J.S., et al. Evidence of myocardial hibernation in the septic heart. Crit Care Med 2005, 33:2752-2756.
21. Liu X., Li P., Widlak P., Zou H., Luo X., Garrard W.T., et al. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci USA 1998, 95(15):8461-8466.
22. Maeder M., Fehr T., Rickli H., Ammann P. Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 2006, 129:1349-1366.
23. Mann D.L., Kent R.L., Parsons B., Cooper G. Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 1992, 85:790-804.
24. Meldrum D.R., Wang M., Tsai B.M., Kher A., Pitcher J.M., Brown J.W., et al. Intracellular signaling mechanisms of sex hormones in acute myocardial inflammation and injury. Front Biosci 2005, 10:1835-1867.
25. Opie L.H., Walpoth B., Barsacchi R. Calcium and catecholamines: relevance to cardiomyopathies and significance in therapeutic strategies. J Mol Cell Cardiol 1985, 17:21-34.
26. Parker M.M., Shelhamer J.H., Bacharach S.L., Green M.V., Natanson C., Frederick T.M., et al. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984, 100:483-490.
27. Parker M.M., McCarthy K.E., Ognibene F.P., Parrillo J.E. Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans. Chest 1990, 97:126-131.
28. Parrillo J.E. Cardiovascular dysfunction in septic shock: new insights into a deadly disease. Int J Cardiol 1985, 7:314-321.
29. Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol. 1985, 17:291-306.
30. Sam A.D., Sharma A.C., Law W.R., Ferguson J.L. Splanchnic vascular control during sepsis and endotoxemia. Front Biosci 1997, 2:e72-e92.
31. Schiller N.B., Shah P.M., Crawford M., DeMaria A., Devereux R., Feigenbaum H., et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989, 2:358-367.
32. Sharma A.C. Sepsis-induced myocardial dysfunction. Shock 2007, 28:265-269.
33. Sharma A.C., Bosmann H.B., Motew S.J., Hales K.H., Hales D.B., Ferguson J.L. Steroid hormone alterations following induction of chronic intraperitoneal sepsis in male rats. Shock 1996, 6(2):150-154.
34. Sharma A.C., Motew S.J., Farias S., Alden K.J., Bosmann H.B., Law W.R., et al. Sepsis alters myocardial and plasma concentrations of endothelin and nitric oxide in rats. J Mol Cell Cardiol 1997, 29:1469-1477.
35. Thijs L.G., Schneider A.J., Groeneveld A.B. The haemodynamics of septic shock. Intensive Care Med 1990, 16:S182-S186.
36. Tung R.H., Garcia C., Morss A.M., Pino R.M., Fifer M.A., Thompson B.T., et al. Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock. Crit Care 2004, 32:1643-1647.