An association test for multiple traits based on the generalized Kendall's Tau

Journal of the American Statistical Association

Volumn 105, Issue 490, 2010, Pages 473-481

  Zhang, Heping ^a,b   Liu, Ching Ti ^c   Wang, Xueqin ^d  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JIANGXI NORMAL UNIVERSITY   (China)

^c BOSTON UNIVERSITY   (United States)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Family based association test (FBAT); Kendall'st; Multivariate phenotypes; Ordinal trait

Indexed keywords

EID: 78649437417     PISSN: 01621459     EISSN: None     Source Type: Journal    
DOI: 10.1198/jasa.2009.ap08387     Document Type: Article

References (41)

1. Abecasis, G., Cardon, L., and Cookson, W. (2000), "A General Test of Association for Quantitative Traits in Nuclear Families," The American Journal of Human Genetics, 66, 279-292. [473]
2. Allison, D. B. (1997), "Transmission-Disequilibrium Tests for Quantitative Traits," The American Journal of Human Genetics, 60, 676-690. [473]
3. American Psychiatric Association (1994), Diagnostic and Statistical Manual of Mental Disorders (4th ed.), Washington, DC: American Psychiatric Press. [476]
4. Arking, D. E., Pfeufer, A., et al. (2006), "A Common Genetic Variant in the NOS1 Regulator NOS1AP Modulates Cardiac Repolarization," Nature Genetics, 38, 644-651. [473]
5. Begleiter, H., Reich, T., et al. (1995), "The Collaborative Study on the Genetics of Alcoholism," Alcohol Health & Research World, 19, 228-236. [476]
6. Benjamini, Y., and Hochberg, Y. (1995), "Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing," Journal of the Royal Statistical Society, Ser. B, 57, 289-300. [475]
7. Bergstrom, H. (1970), "A Comparison Method for Distribution Functions of Sums of Independent and Dependent Random Variables," Theory of Probability and Its Applications, 15, 430-457. [480]
8. Dudoit, S., and Speed, T. P. (2000), "A Score Test for the Linkage Analysis of Qualitative and Quantitative Traits Based on Identity by Descent Data on Sib-Pairs," Biostatistics, 1, 1-26. [474]
9. Duerr, R. H., Taylor, K. D., et al. (2006), "A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene," Science, 314, 1461-1463. [473]
10. Feighner, J. P., Robins, E., et al. (1972), "Diagnostic Criteria for Use in Psychiatric Research," Archives of General Psychiatry, 26, 57-63. [476]
11. Frayling, T. M., Timpson, N. J., et al. (2007), "A Common Variant in the FTO Gene Is Associated With Body Mass Index and Predisposes to Childhood and Adult Obesity," Science, 316, 889-894. [473]
12. Gelernter, J., Panhuysen, C., et al. (2005), "Genomewide Linkage Scan for Cocaine Dependence and Related Traits: Significant Linkages for a Cocaine- Related Trait and Cocaine-Induced Paranoia," American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 136, 45-52. [478]
13. Hasin, D. S., Stinson, F. S., Ogburn, E., and Grant, B. (2007), "Prevelence, Correlates, Disability, and Comorbidity of SDM-IV Alcohol Abuse and Dependence in the United States," Archives of General Psychiatry, 64, 830-842. [476]
14. Hollander, M., and Wolfe, D. A. (1999), Nonparametric Statistical Methods, (2nd ed.), New York: Wiley. [475]
15. Klein, R. J., Zeiss, C., et al. (2005), "Complement Factor H Polymorphism in Age-Related Macular Degeneration," Science, 308, 385-389. [473]
16. Knapp, M. (1999), "Using Exact P Values to Compare the Power Between the Reconstruction-Combined Transmission/Disequilibrium Test and the Sib Transmission/Disequilibrium Test," The American Journal of Human Genetics 65, 1208-1210. [473]
17. Laird, N. M., Horvath, S., and Xu, X. (2000), "Implementing a Unified Approach to Family Based Tests of Association," Genetic Epidemiology, 19, S36-S42. [473]
18. Lambertus, K., Diana, L., Devlin, B., and Roeder, K. (2008), "Pleiotropy and Principal Components of Heritability Combine to Increase Power for Association Analysis," Genetic Epidemiology, 32, 9-19. [473,478]
19. Lange, C., Silverman, E. K., Xu, X., Weiss, S. T., and Laird, N. M. (2003), "A Multivariate Family-Based Association Test Using Generalized Estimating Equations: FBAT-GEE," Biostatistics, 4, 195-306. [473,476,478]
20. Lehmann, E. L. (1983), Theory of Point Estimation, New York: Wiley. [479]
21. Liu, Y., Tritchler, D., and Bull, S. B. (2002), "A Unified Framework for Transmission-Disequilibrium Test Analysis of Discrete and Continuous Traits," Genetic Epidemiology, 22, 26-40. [473]
22. Ma, J. Z., Beuten, J., Payne, T. J., Dupont, R. T., Elston, R. C., and Li, M. (2005), "Haplotype Analysis Indicates an Association Between the DOPA Decarboxylase (DDC) Gene and Nicotine Dependence," Human Molecular Genetics, 14, 1691-1698. [478]
23. Martin, E. R., Monks, S. A., Warren, L. L., and Kaplan, N. L. (2000), "A Test for Linkage and Association in General Pedigrees: The Pedigree Disequilibrium Test," The American Journal of Human Genetics, 67, 146-154. [473]
24. Ott, J. (1999), Analysis of Human Genetic Linkage, Baltimore, MD: The Johns Hopkins University Press. [474]
25. Rabinowitz, D. (1997), "A Transmission Disequilibrium Test for Quantitative Trait Loci," Human Heredity, 47, 342-350. [473,475]
26. Rabinowitz, D., and Laird, N.M. (2000), "A Unified Approach to Adjusting Association Tests for Population AdmixtureWith Arbitrary Pedigree Structure and Arbitrary Missing Marker Information," Human Heredity, 504, 227-233. [473-475]
27. Reich, T., Edenberg, H. J., et al. (1998), "Genome-Wide Search for Genes Affecting the Risk for Alcohol Dependence," American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 81, 207-215. [477,478]
28. Risch, N., and Zhang, H. P. (1995), "Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans," Science, 268, 1584-1589. [474,475]
29. Schaid, D. J., McDonnell, S. K., et al. (2005), "Nonparametric Tests of Association of Multiple Genes With Human Disease," The American Journal of Human Genetics, 76, 780-793. [474]
30. Shugart, Y. Y., Samuels, J., et al. (2006), "Genomewide Linkage Scan for Obsessive-Compulsive Disorder: Evidence for Susceptibility Loci on Chromosomes 3q, 7p, 1q, 15q, and 6q," Molecular Psychiatry, 11, 763-770. [478]
31. Spielman, R. S., and Ewens, W. J. (1998), "A Sibship Test for Linkage in the Presence of Association: The Sib Transmission/Disequilibrium Test," The American Journal of Human Genetics, 62, 450-458. [473]
32. Spielman, R. S., McGinnis, R. E., and Ewens, W. J. (1993), "Transmission Test for Linkage Disequilibrium: The Insulin Gene Region and Insulin- Dependent Diabetes Mellitus (IDDM)," The American Journal of Human Genetics, 52, 506-516. [473]
33. Storey, J. D., and Tibshirani, R. (2003), "Statistical Significance for Genomewide Studies," Proceedings of the National Academy of Sciences, 100, 9440-9445. [475]
34. The Tourette Syndrome Association International Consortium for Genetics (TSAICG) (2007), "Genome Scan for Tourette Disorder in Affected- Sibling-Pair andMultigenerational Families," The American Journal of Human Genetics, 80, 265-272. [478]
35. Tzeng, J.-Y., Devlin, B., Wasserman, L., and Roeder, K. (2003), "On the Identification of Disease Mutations by the Analysis of Haplotype Similarity and Goodness of Fit," The American Journal of Human Genetics, 72, 891-902. [474]
36. Wang, X., Ye, Y., and Zhang, H. (2006), "Family-Based Association Tests for Ordinal Traits Adjusting for Covariates," Genetic Epidemiology, 30, 728- 736. [474]
37. Zhang, H. P., Leckman, J. F., et al. (2002), "Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome," The American Journal of Human Genetics, 70, 896-904. [478]
38. Zhang, H. P., Wang, X., and Ye, Y. (2006), "Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies," Genetics, 172, 693-699. [474-476,478]
39. Zhang, H. P., Ye, Y.,Wang, X., Gelernter, J., Ma, J., and Li, M. (2005), "DOPA Decarboxylase (DDC) Gene Is Associated With Nicotine Dependence," Pharmacogenomics, 7, 1159-1166. [478]
40. Zhu,W., and Zhang, H. P. (2009), "Why DoWe Test Multiple Traits in Genetic Association Studies?" (with discussion), Journal of the Korean Statistical Society, 38, 1-10. [473,478]
41. Zhu, X., Cooper, R., Kan, D., Cao, G., and Wu, X. (2005), "A Genome-Wide Linkage and Association Study Using COGA Data," BMC Genetics, 6, S128. [477]