Detection of genes for ordinal traits in nuclear families and a unified approach for association studies

Genetics

Volumn 172, Issue 1, 2006, Pages 693-699

  Zhang, Heping ^a   Wang, Xueqin ^a   Ye, Yuanqing ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROMODULIN;

ALCOHOLISM; ARTICLE; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC TRAIT; MATHEMATICAL ANALYSIS; MATHEMATICAL GENETICS; NUCLEAR FAMILY; PRIORITY JOURNAL; QUANTITATIVE GENETICS; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ALCOHOLISM; COMPUTER SIMULATION; GAP-43 PROTEIN; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; NUCLEAR FAMILY; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE;

EID: 33644783654     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.105.049122     Document Type: Article

References (18)

1. ALLISON, D. B., 1997 Transmission-disequilibrium test for quantitative traits. Am. J. Hum. Genet. 60: 676-690.
2. BEGLEITER, H., T. REICH, V. HESSELBROCK, B. PORJESZ, T. K. LI et al., 1995 The collaborative study on the genetics of alcoholism. Alcohol Health Res. World 19: 228-236.
3. BLENNOW, K., 2004 Cerebrospinal fluid protein biomarkers for Alzheimer's disease. J. Am. Soc. Exp. Neurother. 1: 213-225.
4. FENG, R., J. LECKMAN and H. P. ZHANG, 2004 Linkage analysis of ordinal traits for pedigree data. Proc. Natl. Acad. Sci. USA 101: 16739-16744.
5. HALL, J. M., M. K. LEE, B. NEWMAN, J. E. MORROW, L. A. ANDERSON et al., 1990 Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250: 1684-1689.
6. HOH, J., A. J. WILLE and J. OTT, 2001 Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res. 11: 2115-2119.
7. KLEIN, R. J., C. ZEISS, E. Y. CHEW, J. Y. TSAI, R. S. SACKLER et al., 2005 Complement factor H polymorphism in age-related macular degeneration. Science 308: 385-389.
8. LIU, Y., D. TRICHLER and S. B. BULL, 2002 A unified framework for transmission-disequilibrium test analysis of discrete and continuous traits. Genet. Epidemiol. 22: 26-40.
9. LUNETTA, K. L., S. V. FARONE, J. BIEDERMAN and N. M. LAIRD, 2000 Family based tests of association and linkage that used unaffected sibs, covariates, and interactions. Am. J. Hum. Genet. 66: 605-614.
10. RABINOWITZ, D, 1997 A transmission disequilibrium test for quantitative trait loci. Hum. Hered. 47: 342-350.
11. RABINOWITZ, D., and N. LAIRD, 2000 A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum. Hered. 50: 211-223.
12. RISCH, N., and K. MERIKANGAS, 1996 The future of genetic studies of complex human diseases. Science 273: 1516-1517.
13. SAUNDERS, D. E., J. H. HANNIGAN, C. S. ZAJAC and N. L. WAPPLER, 1995 Reversal of alcohol's effects on neurite extension and on neuronal GAP43/B50, N-myc, and c-myc protein levels by retinoic acid. Dev. Brain Res. 86: 16-23.
14. SPIELMAN, R. S., and W. J. EWENS, 1998 A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am. J. Hum. Genet. 62: 450-458.
15. SPIELMAN, R. S., R. E. MCGINNIS and W. J. EWENS, 1993 Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52: 506-516.
16. WHITTEMORE, A. S., and I. P. TU, 2000 Detecting disease genes using family data. I. Likelihood-based theory. Am. J. Hum. Genet. 66: 1328-1340.
17. ZHANG, H. P., R. FENG and H. T. ZHU, 2003 A latent variable model of segregation analysis for ordinal traits. J. Am. Stat. Assoc. 98: 1023-1034.
18. ZHANG, K., Z. H. QIN, J. S. LIU, T. CHEN, M. S. WATERMAN et al., 2004 Haplotype block partitioning and tag SNP selection using genotype data and their applications to association studies. Genome Res. 14: 908-916.