Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against HUVEC and some cancer cell lines

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5950-5957

  Cheng, Huimin ^a,c   Zhang, Lianwen ^a,d   Liu, Yingxue ^a   Chen, Shaopeng ^a   Cheng, Hao ^a   Lu, Xin ^a   Zheng, Zhuxia ^a,d   Zhou, Guo Chun ^a,b  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b NANJING TECH UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

5 Hydroxyaurone; Anti angiogenesis agent; Cell invasion; Cell migration; Conventional anticancer agent; Tube formation

Indexed keywords

5 ACETOXY 2 (4 DIETHYLAMINOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 ACETOXY 2 (4 DIMETHYLAMINOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 ACETOXY 2 (4 TERT BUTYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 ACETAMIDOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 AMINOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 BROMOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 CARBAMOYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 CHLOROBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 CYANOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 DIETHYLAMINOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 DIMETHYLAMINOBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 FLUOROBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 HYDROXYBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 ISOPROPYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 METHOXYBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 METHYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 TERT BUTYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 (4 TRIFLUOROMETHYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 [4 (1 PIPERIDINYL)BENZYLIDENE]BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 [4 (1 PYRROLIDINYL)BENZYLIDENE]BENZOFURAN 3(2H)ONE; 5 HYDROXY 2 BENZYLIDENE BENZOFURAN 3(2H) ONE; 5 HYDROXYAURONE DERIVATIVE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CANCER INHIBITION; CELL MOTILITY; CELL PROLIFERATION; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; METASTASIS; UMBILICAL VEIN;

ANTINEOPLASTIC AGENTS; BENZOFURANS; BENZYLIDENE COMPOUNDS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOTHELIAL CELLS; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649331023     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.061     Document Type: Article

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