Synthesis and anticancer effect of B-ring trifluoromethylated flavonoids

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 20, 2003, Pages 3423-3427

  Zheng, Xing ^a   Cao, Jian Guo ^b   Meng, Wei Dong ^a   Qing, Feng Ling ^a,c  

^a DONGHUA UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

^c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5,7 DIPROPOXY 2 (4' TRIFLUOROMETHYLPHENYL)CHROMEN 4 ONE; ANTINEOPLASTIC AGENT; FLAVONOID; METHYL GROUP; PHENYL GROUP; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STOMACH ADENOCARCINOMA;

EID: 0141707084     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00752-2     Document Type: Article

References (18)

1. King, R. J. B., Cancer Biology. 2nd ed.; Pearson Education, 2000.
2. (a) Flavonoids in Health and Disease, Rice-Evans, C. A.; Packer, L. Eds. Marcel Dekker: New York, NY, 1997.
3. (b) Bertrand A., Olivier D. Helv. Chim. Acta. 82:1999;2201.
4. Liu Y.L., Ho D.K., Cassady J.M. J. Nat. Prod. 55:1992;357.
5. Hebtemariam S. J. Nat. Prod. 60:1997;775.
6. Kubo I., Kinst-Hori I., Chaudhuri S.K., Kubo Y., Sanchez Y., Ogura T. Bioorg. Med. Chem. 8:2000;1749.
7. Suresh C.T., Leena S., Sari M., Risto S. J. Med. Food. 2:1999;235.
8. Wang C.F., Kurzer M.S. Nutr. Cancer. 31:1998;90.
9. Welch J.T., Eswarakrishnan S. Flourine in Bioorganic Chemistry; Wiley: New York, 1991.
10. (a) Welch J.T., Eswarakrishnan S. Fluorine in Bioorganic Chemistry. 1991;Wiley, New York, (b) Singh R.P., Shreeve J.M. Tetrahedron. 56:2000;7613.
11. Sachchar S.P., Tripathi N.N., Singh A.K. Ind. J. Chem. 26B:1987;493.
12. Nakamura C., Kawasaki N., Miyataka H., Jayachandran E., Kim I.H., Kirk K.L., Taguchi T., Takeuchi Y., Hori H., Satoh T. Bioorg. Med. Chem. 10:2002;699.
13. Zheng X., Meng W.D., Xu Y.Y., Cao J.G., Qing F.L. Bioorg. Med. Chem. Lett. 13:2003;881.
14. Boumendjel A., Bois F., Beney C., Mariotte A.M., Conseil A., Pietro A.D. Bioorg. Med. Chem. Lett. 11:2001;75.
15. Chen J.J., Yang W.W., Pan X.F., Tan Z. Acta Chimica Sin. 45:1987;503.
16. Beney C., Mariotte A.M., Boumendjel A. Heterocycles. 55:2001;967.
17. Mosman T.J. Immunol. Methods. 65:1983;55.
18. 3): 1.066-1.114 (6H, m), 1.839-1.970 (4H, m), 4.014-4.111 (4H, m), 6.147 (1H, s), 6.373 (1H, s), 6.708 (1H, s), 7.670 (2H, d, J=8.1 Hz), 7.958 (2H, d, J=8.1 Hz).