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Volumn 7, Issue 2, 2010, Pages

Fixing ryanodine receptor Ca2+ leak - A novel therapeutic strategy for contractile failure in heart and skeletal muscle

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; BENZOTHIAZEPINE DERIVATIVE; CALCIUM ION; FK 506 BINDING PROTEIN; RYANODINE RECEPTOR; S 107; UNCLASSIFIED DRUG;

EID: 78649324563     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2010.09.009     Document Type: Review
Times cited : (73)

References (44)
  • 1
    • 0034024566 scopus 로고    scopus 로고
    • Survival of patients with a new diagnosis of heart failure: A population based study
    • M.R. Cowie Survival of patients with a new diagnosis of heart failure: a population based study Heart 83 2000 505 510
    • (2000) Heart , vol.83 , pp. 505-510
    • Cowie, M.R.1
  • 2
    • 3042846005 scopus 로고    scopus 로고
    • Sparking the failing heart
    • M.A. Farr, and C.T. Basson Sparking the failing heart N. Engl. J. Med. 351 2004 185 187
    • (2004) N. Engl. J. Med. , vol.351 , pp. 185-187
    • Farr, M.A.1    Basson, C.T.2
  • 3
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2010 update: A report from the American Heart Association
    • D. Lloyd-Jones Heart disease and stroke statistics - 2010 update: a report from the American Heart Association Circulation 121 2010 e46 e215
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1
  • 4
    • 61949338001 scopus 로고    scopus 로고
    • Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
    • A.M. Bellinger Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle Nat. Med. 15 2009 325 330
    • (2009) Nat. Med. , vol.15 , pp. 325-330
    • Bellinger, A.M.1
  • 5
    • 0034640113 scopus 로고    scopus 로고
    • PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
    • S.O. Marx PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts Cell 101 2000 365 376
    • (2000) Cell , vol.101 , pp. 365-376
    • Marx, S.O.1
  • 6
    • 0021194420 scopus 로고
    • Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
    • J.N. Cohn Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure N. Engl. J. Med. 311 1984 819 823
    • (1984) N. Engl. J. Med. , vol.311 , pp. 819-823
    • Cohn, J.N.1
  • 7
    • 0034107255 scopus 로고    scopus 로고
    • The control of adrenergic function in heart failure: Therapeutic intervention
    • A.L. Clark, and J.G. Cleland The control of adrenergic function in heart failure: therapeutic intervention Heart Fail. Rev. 5 2000 101 114
    • (2000) Heart Fail. Rev. , vol.5 , pp. 101-114
    • Clark, A.L.1    Cleland, J.G.2
  • 8
    • 0028865418 scopus 로고
    • Adverse consequences of high sympathetic nervous activity in the failing human heart
    • D.M. Kaye Adverse consequences of high sympathetic nervous activity in the failing human heart J. Am. Coll. Cardiol. 26 1995 1257 1263
    • (1995) J. Am. Coll. Cardiol. , vol.26 , pp. 1257-1263
    • Kaye, D.M.1
  • 10
    • 0038662725 scopus 로고    scopus 로고
    • Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure
    • S. Reiken Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure Circulation 107 2003 2459 2466
    • (2003) Circulation , vol.107 , pp. 2459-2466
    • Reiken, S.1
  • 11
    • 67649644862 scopus 로고    scopus 로고
    • Mechanisms by which exercise training benefits patients with heart failure
    • E. Crimi Mechanisms by which exercise training benefits patients with heart failure Nat. Rev. Cardiol. 6 2009 292 300
    • (2009) Nat. Rev. Cardiol. , vol.6 , pp. 292-300
    • Crimi, E.1
  • 12
    • 0031539407 scopus 로고    scopus 로고
    • Skeletal muscle function and its relation to exercise tolerance in chronic heart failure
    • D. Harrington Skeletal muscle function and its relation to exercise tolerance in chronic heart failure J. Amer. Coll. Cardiol. 30 1997 1758 1764
    • (1997) J. Amer. Coll. Cardiol. , vol.30 , pp. 1758-1764
    • Harrington, D.1
  • 13
    • 0021895257 scopus 로고
    • Stimulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell
    • DOI 10.1085/jgp.85.2.291
    • A. Fabiato Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell J. Gen. Physiol. 85 1985 291 320 (Pubitemid 15130973)
    • (1985) Journal of General Physiology , vol.85 , Issue.2 , pp. 291-320
    • Fabiato, A.1
  • 14
    • 43549098268 scopus 로고    scopus 로고
    • Calcium cycling and signaling in cardiac myocytes
    • D.M. Bers Calcium cycling and signaling in cardiac myocytes Annu. Rev. Physiol 70 2008 23 49
    • (2008) Annu. Rev. Physiol , vol.70 , pp. 23-49
    • Bers, D.M.1
  • 15
    • 0038464639 scopus 로고    scopus 로고
    • Phospholamban: A crucial regulator of cardiac contractility
    • D.H. Maclennan, and E.G. Kranias Phospholamban: a crucial regulator of cardiac contractility Nat. Rev. Mol. Cell Biol. 4 2003 566 577
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 566-577
    • MacLennan, D.H.1    Kranias, E.G.2
  • 16
    • 38349048508 scopus 로고    scopus 로고
    • Skeletal muscle fatigue: Cellular mechanisms
    • D.G. Allen Skeletal muscle fatigue: cellular mechanisms Physiol. Rev. 88 2008 287 332
    • (2008) Physiol. Rev. , vol.88 , pp. 287-332
    • Allen, D.G.1
  • 17
    • 33745198418 scopus 로고    scopus 로고
    • Redox regulation of cardiac calcium channels and transporters
    • A.V. Zima, and L.A. Blatter Redox regulation of cardiac calcium channels and transporters Cardiovasc. Res. 71 2006 310 321
    • (2006) Cardiovasc. Res. , vol.71 , pp. 310-321
    • Zima, A.V.1    Blatter, L.A.2
  • 18
    • 34548644786 scopus 로고    scopus 로고
    • Modulation of the ryanodine receptor and intracellular calcium
    • R. Zalk Modulation of the ryanodine receptor and intracellular calcium Annu. Rev. Biochem. 76 2007 367 385
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 367-385
    • Zalk, R.1
  • 19
    • 0037049977 scopus 로고    scopus 로고
    • Cardiac excitation-contraction coupling
    • D.M. Bers Cardiac excitation-contraction coupling Nature 415 2002 198 205
    • (2002) Nature , vol.415 , pp. 198-205
    • Bers, D.M.1
  • 20
    • 0022527164 scopus 로고
    • Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists
    • R.W. Tsien Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists J. Mol. Cell Cardiol. 18 1986 691 710
    • (1986) J. Mol. Cell Cardiol. , vol.18 , pp. 691-710
    • Tsien, R.W.1
  • 21
    • 31444432542 scopus 로고    scopus 로고
    • Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression
    • X.H. Wehrens Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression Proc. Natl. Acad. Sci. U. S. A. 103 2006 511 518
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 511-518
    • Wehrens, X.H.1
  • 22
    • 33847058737 scopus 로고    scopus 로고
    • Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase
    • J. Curran Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase Circ. Res. 100 2007 391 398
    • (2007) Circ. Res. , vol.100 , pp. 391-398
    • Curran, J.1
  • 23
    • 0036788917 scopus 로고    scopus 로고
    • Ryanodine receptor calcium release channels
    • M. Fill, and J.A. Copello Ryanodine receptor calcium release channels Physiol. Rev. 82 2002 893 922
    • (2002) Physiol. Rev. , vol.82 , pp. 893-922
    • Fill, M.1    Copello, J.A.2
  • 24
    • 0035858868 scopus 로고    scopus 로고
    • Phosphorylation-dependent regulation of ryanodine receptors: A novel role for leucine/isoleucine zippers
    • S.O. Marx Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers J. Cell Biol. 153 2001 699 708
    • (2001) J. Cell Biol. , vol.153 , pp. 699-708
    • Marx, S.O.1
  • 25
    • 3042763171 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor
    • X.H. Wehrens Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor Circ. Res. 94 2004 e61 70
    • (2004) Circ. Res. , vol.94 , pp. 61-70
    • Wehrens, X.H.1
  • 26
    • 0942290432 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart
    • S. Currie Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart Biochem. J. 377 Pt 2 2004 357 366
    • (2004) Biochem. J. , vol.377 , Issue.PART 2 , pp. 357-366
    • Currie, S.1
  • 27
    • 0026738916 scopus 로고
    • FK506 binding protein associated with the calcium release channel (ryanodine receptor)
    • T. Jayaraman FK506 binding protein associated with the calcium release channel (ryanodine receptor) J. Biol. Chem. 267 1992 9474 9477
    • (1992) J. Biol. Chem. , vol.267 , pp. 9474-9477
    • Jayaraman, T.1
  • 28
    • 0029122138 scopus 로고
    • Affinity purification of the ryanodine receptor/calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12
    • H.B. Xin Affinity purification of the ryanodine receptor/calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12 Biochem. Biophys. Res. Commun. 214 1995 263 270
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 263-270
    • Xin, H.B.1
  • 29
    • 0028358901 scopus 로고
    • Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
    • A.B. Brillantes Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein Cell 77 1994 513 523
    • (1994) Cell , vol.77 , pp. 513-523
    • Brillantes, A.B.1
  • 30
    • 0029934608 scopus 로고    scopus 로고
    • Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle
    • E. Kaftan Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle Circ. Res. 78 1996 990 997
    • (1996) Circ. Res. , vol.78 , pp. 990-997
    • Kaftan, E.1
  • 31
    • 0029807075 scopus 로고    scopus 로고
    • Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes
    • E. McCall Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes Circ. Res. 79 1996 1110 1121
    • (1996) Circ. Res. , vol.79 , pp. 1110-1121
    • McCall, E.1
  • 32
    • 0037708928 scopus 로고    scopus 로고
    • FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death
    • X.H. Wehrens FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death Cell 113 2003 829 840
    • (2003) Cell , vol.113 , pp. 829-840
    • Wehrens, X.H.1
  • 33
    • 0345268757 scopus 로고    scopus 로고
    • PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: Defective regulation in heart failure
    • S. Reiken PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure J. Cell Biol. 160 2003 919 928
    • (2003) J. Cell Biol. , vol.160 , pp. 919-928
    • Reiken, S.1
  • 34
    • 0034711171 scopus 로고    scopus 로고
    • Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure
    • M. Yano Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure Circulation 102 2000 2131 2136
    • (2000) Circulation , vol.102 , pp. 2131-2136
    • Yano, M.1
  • 35
    • 41149180560 scopus 로고    scopus 로고
    • Remodeling of ryanodine receptor complex causes 'leaky' channels: A molecular mechanism for decreased exercise capacity
    • A.M. Bellinger Remodeling of ryanodine receptor complex causes 'leaky' channels: a molecular mechanism for decreased exercise capacity Proc. Natl. Acad. Sci. U. S. A. 105 2008 2198 2202
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 2198-2202
    • Bellinger, A.M.1
  • 36
    • 23744513192 scopus 로고    scopus 로고
    • Ryanodine receptor-targeted anti-arrhythmic therapy
    • X.H. Wehrens Ryanodine receptor-targeted anti-arrhythmic therapy Ann. N. Y. Acad. Sci. 1047 2005 366 375
    • (2005) Ann. N. Y. Acad. Sci. , vol.1047 , pp. 366-375
    • Wehrens, X.H.1
  • 37
    • 38849094092 scopus 로고    scopus 로고
    • Stressed out: The skeletal muscle ryanodine receptor as a target of stress
    • A.M. Bellinger Stressed out: the skeletal muscle ryanodine receptor as a target of stress J. Clin. Invest. 118 2008 445 453
    • (2008) J. Clin. Invest. , vol.118 , pp. 445-453
    • Bellinger, A.M.1
  • 38
    • 76549098001 scopus 로고    scopus 로고
    • Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
    • J. Fauconnier Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy Proc. Natl. Acad. Sci. U. S. A. 107 2010 1559 1564
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 1559-1564
    • Fauconnier, J.1
  • 39
    • 45749100010 scopus 로고    scopus 로고
    • Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice
    • S.E. Lehnart Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice J. Clin. Invest. 118 2008 2230 2245
    • (2008) J. Clin. Invest. , vol.118 , pp. 2230-2245
    • Lehnart, S.E.1
  • 40
    • 30544451804 scopus 로고    scopus 로고
    • Mechanisms of disease: Ryanodine receptor defects in heart failure and fatal arrhythmia
    • M. Yano Mechanisms of disease: ryanodine receptor defects in heart failure and fatal arrhythmia Nat. Clin. Pract. Cardiovasc. Med. 3 2006 43 52
    • (2006) Nat. Clin. Pract. Cardiovasc. Med. , vol.3 , pp. 43-52
    • Yano, M.1
  • 41
    • 1842482414 scopus 로고    scopus 로고
    • Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2
    • X.H. Wehrens Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2 Science 304 2004 292 296
    • (2004) Science , vol.304 , pp. 292-296
    • Wehrens, X.H.1
  • 42
    • 0037469180 scopus 로고    scopus 로고
    • FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure
    • M. Yano FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure Circulation 107 2003 477 484
    • (2003) Circulation , vol.107 , pp. 477-484
    • Yano, M.1
  • 43
    • 22144480949 scopus 로고    scopus 로고
    • Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure
    • X.H. Wehrens Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure Proc. Natl. Acad. Sci. U. S. A. 102 2005 9607 9612
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 9607-9612
    • Wehrens, X.H.1
  • 44
    • 68449103544 scopus 로고    scopus 로고
    • Pharmacological characteristics and clinical applications of K201
    • N. Kaneko Pharmacological characteristics and clinical applications of K201 Curr. Clin. Pharmacol. 4 2009 126 131
    • (2009) Curr. Clin. Pharmacol. , vol.4 , pp. 126-131
    • Kaneko, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.