The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway

Breast Cancer Research and Treatment

Volumn 124, Issue 2, 2010, Pages 307-315

  Oshita, Shayna E ^a   Chen, Feng ^a   Kwan, Toni ^a   Yehiely, Fruma ^a   Cryns, Vincent L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Apoptosis; Heat shock protein; HspB2; MKBP; TNF ; TRAIL

Indexed keywords

CASPASE 10; CASPASE 3; CASPASE 8; HSP2 PROTEIN; PROTEIN BID; SMALL HEAT SHOCK PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER RESISTANCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BREAST NEOPLASMS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FEMALE; HSP27 HEAT-SHOCK PROTEINS; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, NUDE; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSFECTION; TUMOR BURDEN; TUMOR NECROSIS FACTOR-ALPHA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78649322648     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0735-0     Document Type: Article

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