Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 6095-6100

  Gonçalves, Raoni S B ^a,b   Kaiser, Carlos R ^b   Loureno, Maria C S ^c   De Souza, Marcus V N ^a,b   Wardell, James L ^a   Wardell, Solange M S V ^d   Da Silva, Adilson D ^e  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Funda??o Oswaldo Cruz   (Brazil)

^d CHEMSOL   (United Kingdom)

^e FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Mefloquine; Quinoline; Tuberculosis

Indexed keywords

2 [1 (2,8 DIMETHYLQUINOLIN 4 YL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 3 YL]PHENOL; 2,8 DIMETHYL 4 (3 PHENYLHEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL)QUINOLINE; 2,8 DIMETHYL 4 [3 (2 NITROPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL]QUINOLINE; 2,8 DIMETHYL 4 [3 (3 NITROPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL]QUINOLINE; 2,8 DIMETHYL 4 [3 (4 NITROPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL]QUINOLINE; 4 (1 (2,8 DIMETHYLQUINOLIN 4 YL) HEXAHYDRO (1,3) OXAZOLO (3,4 A) PYRIDIN 3 YL) PHENOL; 4 [3 (2 CHLOROPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (2 FLUORO)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (2 METHOXYPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (3 BROMOPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (3 CHLOROPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (3 METHOXYPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (4 BROMOPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (4 CHLOROPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (4 FLUORO)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; 4 [3 (4 METHOXYPHENYL)HEXAHYDRO[1,3]OXAZOLO[3,4 A]PYRIDIN 1 YL] 2,8 DIMETHYLQUINOLINE; ETHAMBUTOL; MEFLOQUINE; MEFLOQUINE OXAZOLIDINE DERIVATIVE; OXAZOLIDINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL VIABILITY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN;

ANTITUBERCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MEFLOQUINE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OXAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649322096     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.024     Document Type: Article

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