Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: Effect of short-term drug discontinuation and comparison with Homer1a-interacting genes

Journal of Psychopharmacology

Volumn 25, Issue 7, 2011, Pages 875-887

  Iasevoli, Felice ^a   Ambesi Impiombato, Alberto ^a   Fiore, Germano ^a   Panariello, Fabio ^a   Muscettola, Giovanni ^a   De Bartolomeis, Andrea ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Clozapine; dopamine; glutamate; haloperidol; homer; in situ hybridization; postsynaptic density; rat brain; schizophrenia; ziprasidone

Indexed keywords

CLOZAPINE; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; HALOPERIDOL; MESSENGER RNA; NEUROLEPTIC AGENT; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN HOMER 1A; ZIPRASIDONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG WITHDRAWAL; GENE; GENE EXPRESSION; GENE INDUCTION; HOMER1A GENE; IN SITU HYBRIDIZATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

ANIMALS; ANTIPSYCHOTIC AGENTS; BASAL GANGLIA; CARRIER PROTEINS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HALOPERIDOL; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; THIAZOLES; TIME FACTORS; UP-REGULATION;

EID: 78649320825     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109358199     Document Type: Article

References (62)

1. Ambesi-Impiombato A, D'Urso G, Muscettola G, de Bartolomeis A. Method for quantitative in situ hybridization histochemistry and image analysis applied for Homer1a gene expression in rat brain. Brain Res Brain Res Protoc. 2003 ; 11: 189-196 (Pubitemid 36782580)
2. Ambesi-Impiombato A, Panariello F, Dell'aversano C, Tomasetti C, Muscettola G, de Bartolomeis A. Differential expression of Homer 1 gene by acute and chronic administration of antipsychotics and dopamine transporter inhibitors in the rat forebrain. Synapse. 2007 ; 61: 429-439 (Pubitemid 46559540)
3. Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR. A complex program of striatal gene expression induced by dopaminergic stimulation. J Neurosci. 1998 ; 18: 5301-5310 (Pubitemid 28311947)
4. Boyson SJ, McGonigle P, Luthin GR, Wolfe BB, Molinoff PB. Effects of chronic administration of neuroleptic and anticholinergic agents on densities of D2 dopamine and muscarinic cholinergic receptors in rat striatum. J Pharmacol Exp Ther. 1988 ; 244: 987-993 (Pubitemid 18090117)
5. Brakeman PR, Lanahan AA, O'Brien R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997 ; 386(6622): 284-288 (Pubitemid 27142514)
6. Critchlow HM, Maycox PR, Skepper JN, Krylova O. Clozapine and haloperidol differentially regulate dendritic spine formation and synaptogenesis in rat hippocampal neurons. Mol Cell Neurosci. 2006 ; 32: 356-365 (Pubitemid 44163231)
7. de Bartolomeis A, Aloj L, Ambesi-Impiombato A, et al. Acute administration of antipsychotics modulates Homer striatal gene expression differentially. Brain Res Mol Brain Res. 2002 ; 98: 124-129 (Pubitemid 34142286)
8. de Bartolomeis A, Fiore G, Iasevoli F. Dopamine-glutamate interaction and antipsychotics mechanism of action: implication for new pharmacological strategies in psychosis. Curr Pharm Des. 2005 ; 11: 3561-3594 (Pubitemid 41300760)
9. Fumagalli F, Frasca A, Racagni G, Riva MA. Antipsychotic drugs modulate Arc expression in the rat brain. Eur Neuropsychopharmacol. 2009 ; 19: 109-115
10. Ghasemzadeh MB, Windham LK, Lake RW, Acker CJ, Kalivas PW. Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: differential regulation by dopamine and glutamate signaling. Synapse. 2009 ; 63: 42-53
11. Hashimoto R, Tankou S, Takeda M, Sawa A. Postsynaptic density: a key convergent site for schizophrenia susceptibility factors and possible target for drug development. Drugs Today (Barc). 2007 ; 43: 645-654 (Pubitemid 350004869)
12. Iasevoli F, Tomasetti C, Ambesi-Impiombato A, Muscettola G, de Bartolomeis A. Dopamine receptor subtypes contribution to Homer1a induction: Insights into antipsychotic molecular action. Prog Neuropsychopharmacol Biol Psychiatry. 2009 ; 33: 813-821
13. Jaubert PJ, Golub MS, Lo YY, et al. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes Brain Behav. 2007 ; 6: 141-154 (Pubitemid 46328585)
14. Jennings CA, Cluderay JE, Gartlon J, et al. The effects of ziprasidone on regional c-Fos expression in the rat forebrain. Psychopharmacology (Berl). 2006 ; 184: 13-20 (Pubitemid 43005752)
15. Kato A, Ozawa F, Saitoh Y, Fukazawa Y, Sugiyama H, Inokuchi K. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J Biol Chem. 1998 ; 273: 23969-23975 (Pubitemid 28435736)
16. Konradi C, Heckers S. Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia. Biol Psychiatry. 2001 ; 50: 729-742 (Pubitemid 33086760)
17. Konradi C, Heckers S. Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther. 2003 ; 97: 153-179 (Pubitemid 36138820)
18. Laruelle M, Frankle WG, Narendran R, Kegeles LS, Abi-Dargham A. Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation. Clin Ther. 2005 ; 27 (Suppl A). S16 - S24
19. Laruelle M, Kegeles LS, Abi-Dargham A. Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment. Ann N Y Acad Sci. 2003 ; 1003: 138-158 (Pubitemid 38083052)
20. Lominac KD, Oleson EB, Pava M, et al. Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. J Neurosci. 2005 ; 25: 11586-11594 (Pubitemid 43098451)
21. Mamo D, Kapur S, Shammi CM, et al. A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone. Am J Psychiatry. 2004 ; 161: 818-825 (Pubitemid 38625334)
22. Marchese G, Bartholini F, Casu MA, et al. Haloperidol versus risperidone on rat "early onset" vacuous chewing. Behav Brain Res. 2004a ; 149: 9-16 (Pubitemid 38096362)
23. Marchese G, Bartholini F, Ruiu S, Casti P, Casu GL, Pani L. Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol. Eur J Pharmacol. 2004b ; 483: 65-69 (Pubitemid 38056605)
24. Marchese G, Casti P, Ruiu S, et al. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol. 2003 ; 140: 520-526 (Pubitemid 37330496)
25. Miletic G, Miyabe T, Gebhardt KJ, Miletic V. Increased levels of Homer1b/c and Shank1a in the post-synaptic density of spinal dorsal horn neurons are associated with neuropathic pain in rats. Neurosci Lett. 2005 ; 386: 189-193 (Pubitemid 41112312)
26. Nemeroff CB, Lieberman JA, Weiden PJ, et al. From clinical research to clinical practice: a 4-year review of ziprasidone. CNS Spectr. 2005 ; 10 (11 Suppl 17). 1-20
27. Nichols CD, Garcia EE, Sanders-Bush E. Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration. Brain Res Mol Brain Res. 2003 ; 111: 182-188 (Pubitemid 36332342)
28. Norton N, Williams HJ, Williams NM, et al. Mutation screening of the Homer gene family and association analysis in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003 ; 120B: 18-21 (Pubitemid 37059373)
29. Okabe S. Molecular anatomy of the postsynaptic density. Mol Cell Neurosci. 2007 ; 34: 503-518 (Pubitemid 46483087)
30. Pani L, Pira L, Marchese G. Antipsychotic efficacy: relationship to optimal D2-receptor occupancy. Eur Psychiatry. 2007 ; 22: 267-275 (Pubitemid 47096691)
31. Paxinos G, Watson C The Rat Brain in Stereotaxic Coordinates. Sydney: Academic Press ; 1997 :
32. Polese D, de Serpis AA, Ambesi-Impiombato A, Muscettola G, de Bartolomeis A. Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of D-cycloserine. Neuropsychopharmacology. 2002 ; 27: 906-913 (Pubitemid 35447627)
33. Robbins MJ, Critchlow HM, Lloyd A, et al. Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT-PCR study. J Psychopharmacol. 2008 ; 22: 536-542
34. Robbins MJ, Starr KR, Honey A, et al. Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia. Brain Res. 2007 ; 1152: 215-227 (Pubitemid 46823886)
35. Robertson GS, Fibiger HC. Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine. Neuroscience. 1992 ; 46: 315-328
36. Robinet EA, Geurts M, Maloteaux JM, Pauwels PJ. Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA. Neurosci Lett. 2001 ; 307: 45-48 (Pubitemid 32539305)
37. Sala C, Futai K, Yamamoto K, Worley PF, Hayashi Y, Sheng M. Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. J Neurosci. 2003 ; 23: 6327-6337 (Pubitemid 36875634)
38. Sala C, Roussignol G, Meldolesi J, Fagni L. Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J Neurosci. 2005 ; 25: 4587-4592 (Pubitemid 40629149)
39. Seeger TF, Seymour PA, Schmidt AW, et al. Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther. 1995 ; 275: 101-113
40. Seeman P, Tallerico T. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol Psychiatry. 1998 ; 3: 123-134 (Pubitemid 28149553)
41. Semba J, Sakai MW, Suhara T, Akanuma N. Differential effects of acute and chronic treatment with typical and atypical neuroleptics on c-fos mRNA expression in rat forebrain regions using non-radioactive in situ hybridization. Neurochem Int. 1999 ; 34: 269-277 (Pubitemid 29307792)
42. Sheng M, Hoogenraad CC. The postsynaptic architecture of excitatory synapses: a more quantitative view. Annu Rev Biochem. 2007 ; 76: 823-847
43. Steiner H, Gerfen CR. Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum. J Neurosci. 1993 ; 13: 5066-5081 (Pubitemid 24000994)
44. Stimmel GL, Gutierrez MA, Lee V. Ziprasidone: an atypical antipsychotic drug for the treatment of schizophrenia. Clin Ther. 2002 ; 24: 21-37 (Pubitemid 34117522)
45. Stone JM, Morrison PD, Pilowsky LS. Glutamate and dopamine dysregulation in schizophrenia-a synthesis and selective review. J Psychopharmacol. 2007 ; 21: 440-452 (Pubitemid 47077295)
46. Szumlinski KK, Kalivas PW, Worley PF. Homer proteins: implications for neuropsychiatric disorders. Curr Opin Neurobiol. 2006 ; 16: 251-257
47. Szumlinski KK, Lominac KD, Kleschen MJ, et al. Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia. Genes Brain Behav. 2005 ; 4: 273-288 (Pubitemid 41002403)
48. Tappe A, Kuner R. Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family. Proc Natl Acad Sci U S A. 2006 ; 103: 774-779 (Pubitemid 43153101)
49. Tomasetti C, Dell'Aversano C, Iasevoli F, de Bartolomeis A. Homer splice variants modulation within cortico-subcortical regions by dopamine D2 antagonists, a partial agonist, and an indirect agonist: implication for glutamatergic postsynaptic density in antipsychotics action. Neuroscience. 2007 ; 150: 144-158 (Pubitemid 350198687)
50. Toro C, Deakin JF. NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder. Schizophr Res. 2005 ; 80: 323-330 (Pubitemid 41713658)
51. Toro CT, Hallak JE, Dunham JS, Deakin JF. Glial fibrillary acidic protein and glutamine synthetase in subregions of prefrontal cortex in schizophrenia and mood disorder. Neurosci Lett. 2006 ; 404: 276-281 (Pubitemid 44108429)
52. Tu JC, Xiao B, Naisbitt S, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999 ; 23: 583-592 (Pubitemid 29359928)
53. Turrone P, Remington G, Kapur S, Nobrega JN. Differential effects of within-day continuous vs. transient dopamine D2 receptor occupancy in the development of vacuous chewing movements (VCMs) in rats. Neuropsychopharmacology. 2003 ; 28: 1433-1439 (Pubitemid 41070877)
54. Westerink BH. Can antipsychotic drugs be classified by their effects on a particular group of dopamine neurons in the brain?. Eur J Pharmacol. 2002 ; 455: 1-18 (Pubitemid 35335960)
55. Willuhn I, Sun W, Steiner H. Topography of cocaine-induced gene regulation in the rat striatum: relationship to cortical inputs and role of behavioural context. Eur J Neurosci. 2003 ; 17: 1053-1066 (Pubitemid 36411602)
56. Xiao B, Tu JC, Petralia RS, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998 ; 21: 707-716 (Pubitemid 28498780)
57. Yamada H, Kuroki T, Nakahara T, et al. The dopamine D1 receptor agonist, but not the D2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens. Brain Res. 2007 ; 1131: 88-96 (Pubitemid 46053909)
58. Yamamoto K, Sakagami Y, Sugiura S, Inokuchi K, Shimohama S, Kato N. Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells. Eur J Neurosci. 2005 ; 22: 1338-1348 (Pubitemid 41442407)
59. Yano M, Steiner H. Methylphenidate (Ritalin) induces Homer 1a and zif 268 expression in specific corticostriatal circuits. Neuroscience. 2005 ; 132: 855-865
60. Zhang GC, Mao LM, Liu XY, et al. In vivo regulation of Homer1a expression in the striatum by cocaine. Mol Pharmacol. 2007a ; 71: 1148-1158
61. Zhang J, Vinuela A, Neely MH, et al. Inhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem. 2007b ; 282: 15778-15789 (Pubitemid 47093305)
62. Zhang J, Xu TX, Hallett PJ, et al. PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. J Neurosci. 2009 ; 29: 2948-2960