2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 13, 2004, Pages 3535-3538

  Prasad, C V C ^a   Vig, Shikha ^a   Smith, David W ^a   Gao, Qi ^a   Polson, Craig T ^a   Corsa, Jason A ^a   Guss, Valerie L ^a   Loo, Alice ^a   Barten, Donna M ^a   Zheng, Ming ^a   Felsenstein, Kevin M ^a   Roberts, Susan B ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; GAMMA SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; CONTROLLED STUDY; ENZYME INHIBITION; HYDROGEN BOND; MOUSE; NONHUMAN; X RAY CRYSTALLOGRAPHY;

ALZHEIMER DISEASE; AMIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BENZODIAZEPINES; BRAIN; CELL LINE; DRUG DESIGN; ENDOPEPTIDASES; INHIBITORY CONCENTRATION 50; KETONES; MICE; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PROTEASE INHIBITORS; PROTEIN BINDING;

EID: 2942538366     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.056     Document Type: Article

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20. 3): 0.80-1.25 (m, 12H), 1.88-2.05 (m, 1H), 3.25-3.49 (s, 5H), 4.32-4.52 (m, 2H), 5.18 (m, 1H), 6.08-6.18 (m, 1H) 5.09-5.10 (d, 1H), 6.66-7.80 (m, 7H); MS (ESI) 501.23 (M+H)