Immunohistochemical analysis of Sox9 in ovarian sertoli cell tumors and other tumors in the differential diagnosis

International Journal of Gynecological Pathology

Volumn 26, Issue 1, 2007, Pages 1-9

  Zhao, Chengquan ^a,c,e   Bratthauer, Gary L ^a   Barner, Ross ^a   Vang, Russell ^b,d  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Immunohistochemistry; Ovary; Sertoli cell tumor; Sox9

Indexed keywords

TRANSCRIPTION FACTOR SOX9;

ARTICLE; CARCINOID; CELL DIFFERENTIATION; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; ENDOMETRIOID CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SERTOLI CELL TUMOR; STAINING; STATISTICAL SIGNIFICANCE;

CARCINOID TUMOR; CELL DIFFERENTIATION; DIAGNOSIS, DIFFERENTIAL; FEMALE; HIGH MOBILITY GROUP PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; OVARIAN NEOPLASMS; SERTOLI CELL TUMOR; TRANSCRIPTION FACTORS;

EID: 33845955417     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pgp.0000232026.22861.b5     Document Type: Article

References (40)

1. Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary. A clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol 2005;29:143-56.
2. Zhao C, Bratthauer GL, Barner R, et al. Comparative analysis of immunohistochemical markers for the distinction of ovarian Sertoli cell tumor from endometroid tumors and carcinoid tumor: a study of 160 cases. Am J Surg Pathol, in press.
3. Dionigi A, Facco C, Tibiletti MG, et al. Ovarian metastases from colorectal carcinoma. Clinicopathologic profile, immunophenotype, and karyotype analysis. Am J Clin Pathol 2000;114:111-22.
4. Lugli A, Forster Y, Haas P, et al. Calretinin expression in human normal and neoplastic tissues: a tissue microarray analysis on 5233 tissue samples. Hum Pathol 2003;34:994-1000.
5. Bishop CE, Whitworth DJ, Qin Y, et al. A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse. Nat Genet 2000;26:490-4.
6. Chaboissier MC, Kobayashi A, Vidal VI, et al. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 2004;131:1891-901.
7. de Santa Barbara P, Moniot B, Ponlat F, et al. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev Dyn 2000;217:293-8.
8. Foster JW. Mutation in SOX9 cause both autosomal sex reversal and campomelic dysplasia. Acta Paediatr Jpn 1996;38:405-11.
9. Hanley NA, Hagan DM, Clement-Jones M, et al. SRY, SOX9, and DAX1 expression patterns during human sex determination and gonadal development. Mech Dev 2000;91:403-7.
10. Kent J, Wheatley S, Andrews J, et al. A male specific role for Sox9 in vertebrate sex determination. Development 1996;122:2813-22.
11. Kobayashi A, Chang H, Chaboissier MC, et al. Sox9 in testis determination. Ann N Y Acad Sci 2005;1061:9-17.
12. Malki S, Berta P, Poulat F, et al. Cytoplasmic retention of the sex-determining factor Sox9 via the microtubule network. Exp Cell Res 2005;309:468-75.
13. 2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. EMBO J 2005;24:1798-809.
14. Morais da Silva S, Hacker A, Harley V, et al. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 1996;14:62-8.
15. Notarnicola C, Malki S, Berta P, et al. Transient expression of SOX9 protein during follicular development in the adult mouse ovary. Gene Expr Patterns. 2005;280:38625-30.
16. Sekido R, Bar I, Narvaez V, et al. Sox9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors. Dev Biol 2004;274:271-9.
17. Vidal VP, Chaboissier MC, de Rooij DG, et al. Sox9 induces testis development in XX transgenic mice. Nat Genet 2001;28:216-7.
18. Wagner T, Wirth J, Meyer J, et al. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell 1994;79:1111-20.
19. Wilhelm D, Martinson F, Bradford S, et al. Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol 2005;287:111-24.
20. Bratthauer GL. The avidin-biotin complex (ABC) method and other avidin-biotin binding methods. In: Javois LC, ed. Methods in Molecular Biology. Vol. 115: Immunocytochemical Methods and Protocols, 2nd ed. Totowa, NJ: Humana Press, Inc, 1999:203-14.
21. Cathro HP, Stoler MH. The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors. Hum Pathol 2005;36:195-201.
22. McCluggage WG, Maxwell P. Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord-stromal tumours. Histopathology 2001;38:403-8.
23. Movahedi-Lankarani S, Kurman RJ. Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases. Am J Surg Pathol 2002;26:1477-83.
24. Britt KL, Kerr J, O'Donnell L, et al. Estrogen regulates development of the somatic cell phenotype in the eutherian ovary. FASEB J 2002;16:1389-97.
25. Couse JF, Hewitt SC, Bunch DO, et al. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 1999;286:2328-31.
26. Dupont S, Dennefeld C, Krust A, et al. Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERalpha and ERbeta. Dev Dyn 2003;226:103-6.
27. Neubecker RD, Breen SL. Gynandroblastoma. A report of five cases, with a discussion of the histogenesis and classification of ovarian tumors. Am J Clin Pathol 1962;38:60-9.
28. Vang R, Herrmann ME, Tavassoli FA. Comparative immunohistochemical analysis of granulosa and Sertoli components in ovarian sex cord-stromal tumors with mixed differentiation: potential implications for derivation of Sertoli differentiation in ovarian tumors. Int J Gynecol Pathol 2004;23:151-61.
29. Clement PB, Young RH, Scully RE. Ovarian granulosa cell proliferations of pregnancy: a report of nine cases. Hum Pathol 1988;19:657-62.
30. Scully RE. Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer 1970;25:1107-21.
31. Young RH, Welch WR, Dickersin GR, et al. Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix. Cancer 1982;50:1384-402.
32. Chalvardjian A, Derzko C. Gynandroblastoma: its ultrastructure. Cancer 1982;50:710-21.
33. Albrecht KH, Eicher EM. Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor. Dev Biol 2001;240:92-107.
34. Kato N, Fukase M, Motoyama T. Expression of a transcription factor, Sox9, in Sertoli-stromal cell tumors of the ovary. Int J Gynecol Pathol 2004;23:180-1.
35. Miller SJ, Rangwala F, Williams J, et al. Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res 2006;66:2584-91.
36. Orlandi A, Ciucci A, Ferlosio A, et al. Cardiac myxoma cells exhibit embryonic endocardial stem cell features. J Pathol. 2006;209:231-9.
37. Soderstrom M, Bohling T, Ekfors T, et al. Molecular profiling of human chondrosarcomas for matrix production and cancer markers. Int J Cancer 2002;100:144-51.
38. Vidal VP, Chaboissier MC, Lutzkendorf S, et al. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 2005;15:1340-51.
39. Wehrli BM, Huang W, De Crombrugghe B, et al. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol 2003;34:263-9.
40. Young RH, Scully RE. Ovarian tumors of probable wolffian origin. A report of 11 cases. Am J Surg Pathol 1983;7:125-35.