Divergent differentiation in malignant soft tissue neoplasms: The paradigm of liposarcoma and malignant peripheral nerve sheath tumor

International Journal of Surgical Pathology

Volumn 13, Issue 1, 2005, Pages 19-28

  Pytel, Peter ^a   Taxy, Jerome B ^a   Krausz, Thomas ^a,b  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b MC6101 ^*  (United States)

Author keywords

Differentiation; Divergent; Liposarcoma; MPNST; Triton tumor

Indexed keywords

CELL DIFFERENTIATION; CYTOPATHOLOGY; DIAGNOSTIC ACCURACY; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LIPOSARCOMA; MELANOCYTE; NERVE SHEATH TUMOR; PERIPHERAL NERVE TUMOR; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SARCOMA; SOFT TISSUE TUMOR; TUMOR CELL;

EID: 13544272909     PISSN: 10668969     EISSN: None     Source Type: Journal    
DOI: 10.1177/106689690501300103     Document Type: Review

References (98)

1. Bitterman P, Chun B, Kurman RJ. The significance of epithelial differentiation in mixed mesodermal tumors of the uterus. A clinicopathologic and immunohistochemical study. Am J Surg Pathol 14:317-328, 1990
2. Abeln EC, Smit VT, Wessels JW, de Leeuw WJ, Cornelisse CJ, Fleuren GJ. Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed müllerian tumours. J Pathol 183:424-431, 1997
3. Paulus W, Bayas A, Ott G, Roggendorf W. Interphase cytogenetics of glioblastoma and gliosarcoma. Acta Neuropathol (Berl) 88:420-425, 1994
4. Boerman RH, Anderl K, Herath J, Borell T, Johnson N, Schaeffer-Klein J, Kirchhof A, Raap AK, Scheithauer BW, Jenkins RB. The glial and mesenchymal elements of gliosarcomas share similar genetic alterations. J Neuropathol Exp Neurol 55:973-981, 1996
5. Biernat W, Aguzzi A, Sure U, Grant JW, Kleihues P, Hegi ME. Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells. J Neuropathol Exp Neurol 54:651-656, 1995
6. Pearson JM, Harris M, Eyden BP, Banerjee SS. Divergent differentiation in small round cell tumours of the soft tissues with neural features - an analysis of 10 cases. Histopathology 23:1-9, 1993
7. Zhang PJ, Goldblum JR, Pawel BR, Fisher C, Pasha TL, Barr FG. Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product. Mod Pathol 16:229-235, 2003
8. Hirose T, Scheithauer BW, Sano T. Perineurial malignant peripheral nerve sheath tumor (MPNST): A clinicopathologic, immunohistochemical, and ultrastructural study of seven cases. Am J Surg Pathol 22:1368-1378, 1998
9. Ducatman BS, Scheithauer BW, Piepgras DG, Reiman HM, Ilstrup DM. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer 57:2006-2021, 1986
10. Woodruff JM. Pathology of tumors of the peripheral nerve sheath in type I neurofibromatosis. Am J Med Genet 89:23-30, 1999
11. Kourea HP, Bilsky MH, Leung DH, Lewis JJ, Woodruff JM. Subdiaphragmatic and intrathoracic paraspinal malignant peripheral nerve sheath tumors: A clinicopathologic study of 25 patients and 26 tumors. Cancer 82:2191-2203, 1998
12. Daimaru Y, Hashimoto H, Enjoji M. Malignant peripheral nerve-sheath tumors (malignant schwannomas). An immunohistochemical study of 29 cases. Am J Surg Pathol 9:434-444, 1985
13. Sorensen SA, Mulvihill JJ, Nielsen A. Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms. N Engl J Med 314:1010-1015, 1986
14. Mikami Y, Hidaka T, Akisada T, Takemoto T, Irei I, Manabe T. Malignant peripheral nerve sheath tumor arising in benign ancient schwannoma: A case report with an immunohistochemical study. Pathol Int 50:156-161, 2000
15. Woodruff JM, Selig AM, Crowley K, Allen PW. Schwannoma (neurilemoma) with malignant transformation. A rare, distinctive peripheral nerve tumor. Am J Surg Pathol 18:882-895, 1994
16. Damiani S, Manetto V, Carrillo G, Di Blasi A, Nappi O, Eusebi V. Malignant peripheral nerve sheath tumor arising in a "de novo" ganglioneuroma. A case report. Tumori 77:90-93, 1991
17. Ghali VS, Gold JE, Vincent RA, Cosgrove JM. Malignant peripheral nerve sheath tumor arising spontaneously from retroperitoneal ganglioneuroma: A case report, review of the literature, and immunohistochemical study. Hum Pathol 23:72-75, 1992
18. Drago G, Pasquier B, Pasquier D, Pinel N, Rouault-Plantaz V, Dyon JF, Durand C, Armari-Alla C, Plantaz D. Malignant peripheral nerve sheath tumor arising in a "de novo" ganglioneuroma: A case report and review of the literature. Med Pediatr Oncol 28:216-222, 1997
19. Navarro O, Nunez-Santos E, Daneman A, Faria P, Daltro P. Malignant peripheral nerve sheath tumor arising in a previously irradiated neuroblastoma: Report of 2 cases and a review of the literature. Pediatr Radiol 30:176-180, 2000
20. Ducatman BS, Scheithauer BW. Postirradiation neurofibrosarcoma. Cancer 51:1028-1033, 1983
21. Koga T, Iwasaki H, Ishiguro M, Matsuzaki A, Kikuchi M. Losses in chromosomes 17, 19, and 22q in neurofibromatosis type I and sporadic neurofibromas: A comparative genomic hybridization analysis. Cancer Genet Cytogenet 136:113-120, 2002
22. Mechtersheimer G, Otano-Joos M, Ohl S, Benner A, Lehnert T, Willeke F, Moller P, Otto HF, Lichter P, Joos S. Analysis of chromosomal imbalances in sporadic and NF1-associated peripheral nerve sheath tumors by comparative genomic hybridization. Genes Chromosomes Cancer 25:362-369, 1999
23. Mertens F, Rydholm A, Bauer HF, Limon J, Nedoszytko B, Szadowska A, Willen H, Heim S, Mitelman F, Mandahl N. Cytogenetic findings in malignant peripheral nerve sheath tumors. Int J Cancer 61:793-798, 1995
24. Weiss SW, Goldblum JR. Malignant tumors of the peripheral nerves. In Enzinger and Weiss's soft tissue tumors. Mosby, St. Louis, pp. 1209-1263, 2001
25. Taxy JB, Battifora H, Trujillo Y, Dorfman HD. Electron microscopy in the diagnosis of malignant schwannoma. Cancer 48:1381-1391, 1981
26. Wick MR, Swanson PE, Scheithauer BW, Manivel JC. Malignant peripheral nerve sheath tumor. An immunohistochemical study of 62 cases. Am J Clin Pathol 87:425-433, 1987
27. Hruban RH, Shiu MH, Senie RT, Woodruff JM. Malignant peripheral nerve sheath tumors of the buttock and lower extremity. A study of 43 cases. Cancer 66:1253-1265, 1990
28. Ducatman BS, Scheithauer BW. Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer 54:1049-1057, 1984
29. Woodruff JM, Chernik NL, Smith MC, Millett WB, Foote FW, Jr. Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant "Triton" tumors). Cancer 32:426-439, 1973
30. Daimaru Y, Hashimoto H, Enjoji M. Malignant "triton" tumors: A clinicopathologic and immunohistochemical study of nine cases. Hum Pathol 15:768-778, 1984
31. Woodruff JM, Perino G. Non-germ-cell or teratomatous malignant tumors showing additional rhabdomyoblastic differentiation, with emphasis on the malignant Triton tumor. Semin Diagn Pathol 11:69-81, 1994
32. Brooks JS, Freeman M, Enterline HT. Malignant "Triton" tumors. Natural history and immunohistocheinistry of nine new cases with literature review. Cancer 55:2543-2549, 1985
33. Wanebo JE, Malik JM, VandenBerg SR, Wanebo HJ, Driesen N, Persing JA. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 71:1247-1253, 1993
34. Matsui I, Tanimura M, Kobayashi N, Sawada T, Nagahara N, Akatsuka J. Neurofibromatosis type I and childhood cancer. Cancer 72:2746-2754, 1993
35. Kurtkaya-Yapicier O, Scheithauer BW, Woodruff JM, Wenger DD, Cooley AM, Dominique D. Schwannoma with rhabdomyoblastic differentiation: A unique variant of malignant triton tumor. Am J Surg Pathol 27:848-853, 2003
36. Tomlinson FH, Scheithauer BW, Kelly PJ, Forbes GS. Subependymoma with rhabdomyosarcomatous differentiation: Report of a case and literature review. Neurosurgery 28:761-768, 1991
37. Stapleton SR, Harkness W, Wilkins PR, Uttley D. Gliomyosarcoma: An immunohistochemical analysis. J Neurol Neurosurg Psychiatry 55:728-730, 1992
38. Cheema ZF, Cannon TC, Leech R, Brennan J, Adesina A, Brumback RA. Medullomyoblastoma: Case report. J Child Neurol 16:598-599, 2001
39. Kalimo H, Paljarvi L, Ekfors T, Pelliniemi LJ. Pigmented primitive neuroectodermal tumor with multipotential differentiation in cerebellum (pigmented medullomyoblastoma). A case with light-and electron-microscopic, and immunohistochemical analysis. Pediatr Neurosci 13:188-195, 1987
40. Dickson DW, Hart MN, Menezes A, Cancilla PA. Medulloblastoma with glial and rhabdomyoblastic differentiation. A myoglobin and glial fibrillary acidic protein immunohistochemical and ultrastructural study. J Neuropathol Exp Neurol 42:639-647, 1983
41. Mouton SC, Rosenberg HS, Cohen MC, Drut R, Emms M, Kaschula RO. Malignant ectomesenchymoma in childhood. Pediatr Pathol Lab Med 16:607-624, 1996
42. Apostolides PJ, Spetzler RF, Johnson PC. Ectomesenchymal hamartoma (benign "ectomesenchymoma") of the VIIIth nerve: Case report. Neurosurgery 37:1204-1207, 1995
43. Muller HL, Marx A, Trusen M, Schneider P, Kuhl J. Disseminated malignant ectomesenchymoma (MEM): Case report and review of the literature. Pediatr Hematol Oncol 19:9-17, 2002
44. Azzopardi JG, Eusebi V, Tison V, Betts CM. Neurofibroma with rhabdomyomatous differentiation: Benign 'Triton' tumour of the vagina. Histopathology 7:561-572, 1983
45. Bonneau R, Brochu P. Neuromuscular choristoma. A clinicopathologic study of two cases. Am J Surg Pathol 7:521-528, 1983
46. Mitchell A, Scheithauer BW, Ostertag H, Sepehrnia A, Sav A. Neuromuscular choristoma. Am J Clin Pathol 103:460-465, 1995
47. Meis JM, Enzinger FM, Martz KL, Neal JA. Malignant peripheral nerve sheath tumors (malignant schwannomas) in children. Am J Surg Pathol 16:694-707, 1992
48. Macaulay RA. Neurofibrosarcoma of the radial nerve in von Recklinghausen's disease with metastatic angiosarcoma. J Neurol Neurosurg Psychiatry 41:474-478, 1978
49. Brown RW, Tornos C, Evans HL. Angiosarcoma arising from malignant schwannoma in a patient with neurofibromatosis. Cancer 70:1141-1144, 1992
50. Morphopoulos GD, Banerjee SS, Ali HH, Stewart M, Vasudev KS, Eyden BP, Harris M. Malignant peripheral nerve sheath tumour with vascular differentiation: A report of four cases. Histopathology 28:401-410, 1996
51. Mentzel T, Katenkamp D. Intraneural angiosarcoma and angiosarcoma arising in benign and malignant peripheral nerve sheath tumours: Clinicopathological and immunohistochemical analysis of four cases. Histopathology 35:114-120, 1999
52. Ruckert RI, Fleige B, Rogalla P, Woodruff JM. Schwannoma with angiosarcoma. Report of a case and comparison with other types of nerve tumors with angiosarcoma. Cancer 89:1577-1585, 2000
53. McMenamin ME, Fletcher CD. Expanding the spectrum of malignant change in schwannomas: Epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: A study of 17 cases. Am J Surg Pathol 25:13-25, 2001
54. Vallat-Decouvelaere AV, Wassef M, Lot G, Catala M, Moussalam M, Caruel N, Mikol J. Spinal melanotic schwannoma: A tumour with poor prognosis. Histopathology 35:558-566, 1999
55. Fetsch JF, Michal M, Miettinen M. Pigmented (melanotic) neurofibroma: A clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients. Am J Surg Pathol 24:331-343, 2000
56. Christensen WN, Strong EW, Bains MS, Woodruff JM. Neuroendocrine differentiation in the glandular peripheral nerve sheath tumor. Pathologic distinction from the biphasic synovial sarcoma with glands. Am J Surg Pathol 12:417-426, 1988
57. Woodruff JM, Christensen WN. Glandular peripheral nerve sheath tumors. Cancer 72:3618-3628, 1993
58. Uri AK, Witzleben CL, Raney RB. Electron microscopy of glandular schwannoma. Cancer 53:493-497, 1984
59. Ni K, Dehner LP. Schwannoma with metastatic carcinoma of the breast: An unconventional form of glandular peripheral sheath tumor. Hum Pathol 26:457-459, 1995
60. Graham A, Begbie J, McGonnell I. Significance of the cranial neural crest. Dev Dyn 229:5-13, 2004
61. Oram KF, Carver EA, Gridley T. Slug expression during organogenesis in mice. Anat Rec 271A:189-191, 2003
62. Perez-Pomares JM, Munoz-Chapuli R. Epithelial-mesenchymal transitions: A mesodermal cell strategy for evolutive innovation in Metazoans. Anat Rec 268:343-351, 2002
63. Dei Tos AP. Liposarcoma: New entities and evolving concepts. Ann Diagn Pathol 4:252-266, 2000
64. Rieker RJ, Joos S, Bartsch C, Willeke F, Schwarzbach M, Otano-Joos M, Ohl S, Hogel J, Lehnert T, Lichter P, Otto HF, Mechtersheimer G. Distinct chromosomal imbalances in pleomorphic and in high-grade dedifferentiated liposarcomas. Int J Cancer 99:68-73, 2002
65. Henricks WH, Chu YC, Goldblum JR, Weiss SW. Dedifferentiated liposarcoma: A clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol 21:271-281, 1997
66. Hasegawa T, Seki K, Hasegawa F, Matsuno Y, Shimodo T, Hirose T, Sano T, Hirohashi S. Dedifferentiated liposarcoma of retroperitoneum, and mesentery: Varied growth patterns and histological grades - a clinicopathologic study of 32 cases. Hum Pathol 31:717-727, 2000
67. DiCarlo EF, Woodruff JM, Bansal M, Erlandson RA. The purely epithelioid malignant peripheral nerve sheath tumor. Am J Surg Pathol 10:478-490, 1986
68. Evans HL, Khurana KK, Kemp BL, Ayala AG. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol 18:1150-1157, 1994
69. Fanburg-Smith JC, Miettinen M. Liposarcoma with meningothelial-like whorls: A study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. Histopathology 33:414-424, 1998
70. Nascimento AG, Kurtin PJ, Guillou L, Fletcher CD. Dedifferentiated liposarcoma: A report of nine cases with a peculiar neural-like whorling pattern associated with metaplastic bone formation. Am J Surg Pathol 22:945-955, 1998
71. Coindre JM, Mariani O, Chibon F, Mairal A, De Saint Aubain Somerhausen N, Favre-Guillevin E, Bui NB, Stoeckle E, Hostein I, Aurias A. Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: A review of 25 cases initially diagnosed as malignant fibrous histiocytoma. Mod Pathol 16:256-262, 2003
72. Salo JC, Lewis JJ, Woodruff JM, Leung DH, Brennan MF. Malignant fibrous histiocytoma of the extremity. Cancer 85:1765-1772, 1999
73. Downes KA, Goldblum JR, Montgomery EA, Fisher C. Pleomorphic liposarcoma: A clinicopathologic analysis of 19 cases. Mod Pathol 14:179-184, 2001
74. Hong KH, Seo SY, Lee DG. Chondrolipoma of the nasopharynx. J Laryngol Otol 112:75-76, 1998
75. Katzer B. Histopathology of rare chondroosteoblastic metaplasia in benign lipomas. Pathol Res Pract 184:437-445, 1989
76. Piattelli A, Fioroni M, Iezzi G, Rubini C. Osteolipoma of the tongue. Oral Oncol 37:468-470, 2001
77. Hazarika P, Pujary K, Kundaje HG, Rao PL. Osteolipoma of the skull base. J Laryngol Otol 115:136-139, 2001
78. Michal M. Retroperitoneal myolipoma. A tumour mimicking retroperitoneal angiomyolipoma and liposarcoma with myosarcomatous differentiation. Histopathology 25:86-88, 1994
79. Meis JM, Enzinger FM. Myolipoma of soft tissue. Am J Surg Pathol 15:121-125, 1991
80. Lin KC, Sheu BC, Huang SC. Lipoleiomyoma of the uterus. Int J Gynaecol Obstet 67:47-49, 1999
81. Shintaku M. Lipoleiomyomatous tumors of the uterus: A heterogeneous group? Histopathological study of five cases. Pathol Int 46:498-502, 1996
82. Folpe AL, Weiss SW. Lipoleiomyosarcoma (well-differentiated liposarcoma, with leiomyosarcomatous differentiation): A clinicopathologic study of nine cases including one with dedifferentiation. Am J Surg Pathol 26:742-749, 2002
83. Shanks JH, Banerjee SS, Eyden BP. Focal rhabdomyosarcomatous differentiation in primary liposarcoma. J Clin Pathol 49:770-772, 1996
84. Govender D, Pillay P. Primary myxoid liposarcoma with rhabdomyoblastic differentiation. Arch Pathol Lab Med 122:740-742, 1998
85. Dijkhuizen T, Molenaar WM, Hockstra HI, Wiersema J, van den Berg E. Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation. Cancer Genet Cytogenet 92:141-143, 1996
86. Siebert JD, Williams RP, Pulitzer DR. Myxoid liposarcoma with cartilaginous differentiation. Mod Pathol 9:249-252, 1996
87. Panoussopoulos D, Theodoropoulos G, Ch Lazaris A, Papadimitriou K. Focal divergent chondrosarcomatous differentiation in a primary pleomorphic liposarcoma, and expression of transforming growth factor beta. Int J Surg Pathol 12:79-85, 2004
88. Gronthos S, Franklin DM, Leddy HA, Robey PG, Storms RW, Gimble JM. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol 189:54-63, 2001
89. De Ugarte DA, Alfonso Z, Zuk PA, Elbarbary A, Zhu M, Ashjian P, Benhaim P, Hedrick MH, Fraser JK. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett 89:267-270, 2003
90. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279-4295, 2002
91. Suster S, Fisher C. Immunoreactivity for the human hematopoietic progenitor cell antigen (CD34) in lipomatous tumors. Am J Surg Pathol 21:195-200, 1997
92. Fisher C. Divergent differentiation in soft tissue sarcomas. J Clin Pathol 49:697-698, 1996
93. Brady MS, Perino G, Tallini G, Russo P, Woodruff JM. Malignant mesenchymoma. Cancer 77:467-473, 1996
94. Stout AP. Mesenchymoma, the mixed tumor of mesenchymal derivation. Ann Surg 127:278-290, 1948
95. Newman PL, Fletcher CD. Malignant mesenchymoma. Clinicopathologic analysis of a series with evidence of low-grade behaviour. Am J Surg Pathol 15:607-614, 1991
96. Evans HL. Malignant mesenchymoma. In Fletcher CDM, Viani KK, Mertens F (eds): Pathology and Genetics of Tumours of Soft Tissue and Bone. Kleihaes P, Sobin LH: World Health Organization Classification of Tumours; Lyon, IARC Press, p. 215, 2002
97. Presnell SC, Petersen B, Heidaran M. Stem cells in adult tissues. Semin Cell Dev Biol 13:369-376, 2002
98. Korbling M, Estrov Z, Champlin R. Adult stem cells and tissue repair. Bone Marrow Transplant 32(Suppl 1):S23-24, 2003