Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 9, 2007, Pages 2430-2433

  Zhang, Rui ^a   Lei, Lin ^a   Xu, Yun Gen ^a   Hua, Wei Yi ^a   Gong, Guo Qing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Benzoylguanidine derivatives; Myocardial ischemic reperfusion injury; Na+ H+ exchanger; Na+ H+ exchanger inhibitors; Synthesis

Indexed keywords

3 METHYLSULFONYLBENZOYLGUANIDINE; BENZIMIDAZOLE DERIVATIVE; CARIPORIDE; GUANIDINE DERIVATIVE; SODIUM PROTON EXCHANGE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SWELLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NONHUMAN; RAT; REACTION ANALYSIS; REPERFUSION INJURY; STRUCTURE ANALYSIS; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GUANIDINES; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; RATS; REPERFUSION INJURY; SODIUM-HYDROGEN ANTIPORTER;

EID: 33947727275     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.035     Document Type: Article

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