Glucose metabolism after normalization of markers of iron overload by venesection in subjects with hereditary hemochromatosis

Metabolism: Clinical and Experimental

Volumn 59, Issue 12, 2010, Pages 1811-1815

  Hatunic, Mensud ^a   Finucane, Francis M ^a   Norris, Suzanne ^a   Pacini, Giovanni ^b   Nolan, John J ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; FERRITIN; GLUCOSE; INSULIN; TRANSFERRIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DISORDERS OF CARBOHYDRATE METABOLISM; FEMALE; GLUCOSE METABOLISM; HEMOCHROMATOSIS; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; IRON OVERLOAD; MALE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE INSULIN SENSITIVITY INDEX; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PHLEBOTOMY; PRIORITY JOURNAL; QUANTITATIVE INSULIN SENSITIVITY CHECK INDEX;

AGED; GLUCOSE; GLUCOSE TOLERANCE TEST; HEMOCHROMATOSIS; HUMANS; INSULIN RESISTANCE; IRON OVERLOAD; MIDDLE AGED;

EID: 78549294157     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.06.005     Document Type: Article

References (33)

1. Merryweather-Clarke A.T., Pointon J.J., Jouanolle A.M., Rochette J., and Robson K.J. Geography of HFE C282Y and H63D mutations Genet Test 4 2000 183 198
2. Bacon B.R., Powell L.W., Adams P.C., Kresina T.F., and Hoofnagle J.H. Molecular medicine and hemochromatosis: at the crossroads Gastroenterology 116 1999 193 207
3. Ryan E., O'Keane C., and Crowe J. Hemochromatosis in Ireland and HFE Blood Cells Mol Dis 24 1998 428 432
4. Byrnes V., Ryan E., Barrett S., Kenny P., Mayne P., and Crowe J. Genetic hemochromatosis, a Celtic disease: is it now time for population screening? Genet Test 5 2001 127 130
5. Merryweather-Clarke A.T., Pointon J.J., Shearman J.D., and Robson K.J. Global prevalence of putative haemochromatosis mutations J Med Genet 34 1997 275 278
6. Feder J.N., Penny D.M., Irrinki A., Lee V.K., Lebron J.A., and Watson N. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding Proc Natl Acad Sci U S A 95 1998 1472 1477
7. Feder J.N., Tsuchihashi Z., Irrinki A., Lee V.K., Mapa F.A., and Morikang E. The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression J Biol Chem 272 1997 14025 14028
8. Edwards C.Q., Dadone M.M., Skolnick M.H., and Kushner J.P. Hereditary haemochromatosis Clin Haematol 11 1982 411 435
9. Powell LW, Yapp TR. Hemochromatosis. Clin Liver Dis 2000;4:211-28, viii.
10. Ferrannini E. Insulin resistance, iron, and the liver Lancet 355 2000 2181 2182
11. Hatunic M., Finucane F.M., Brennan A.M., Norris S., Pacini G., and Nolan J.J. Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis Metabolism 59 2010 380 384
12. McClain D.A., Abraham D., Rogers J., Brady R., Gault P., and Ajioka R. High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis Diabetologia 49 2006 1661 1669
13. Hramiak I.M., Finegood D.T., and Adams P.C. Factors affecting glucose tolerance in hereditary hemochromatosis Clin Invest Med 20 1997 110 118
14. Utzschneider K.M., and Kowdley K.V. Hereditary hemochromatosis and diabetes mellitus: implications for clinical practice Nat Rev Endocrinol 6 2010 26 33
15. Williams R., Smith P.M., Spicer E.J., Barry M., and Sherlock S. Venesection therapy in idiopathic haemochromatosis. An analysis of 40 treated and 18 untreated patients Q J Med 38 1969 1 16
16. Dymock I.W., Cassar J., Pyke D.A., Oakley W.G., and Williams R. Observations on the pathogenesis, complications and treatment of diabetes in 115 cases of haemochromatosis Am J Med 52 1972 203 210
17. Abraham D., Rogers J., Gault P., Kushner J.P., and McClain D.A. Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis Diabetologia 49 2006 2546 2551
18. Alberti K.G., and Zimmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabet Med 15 1998 539 553
19. Katz A., Nambi S.S., Mather K., Baron A.D., Follmann D.A., and Sullivan G. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans J Clin Endocrinol Metab 85 2000 2402 2410
20. Mari A., Pacini G., Murphy E., Ludvik B., and Nolan J.J. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test Diabetes Care 24 2001 539 548
21. Abdul-Ghani M.A., Jenkinson C.P., Richardson D.K., Tripathy D., and DeFronzo R.A. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study Diabetes 55 2006 1430 1435
22. Stadler M., Anderwald C., Karer T., Tura A., Kastenbauer T., and Auinger M. Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation: a sign of impaired beta-cell function? Diabetes Care 29 2006 1031 1038
23. Ludvik B., Waldhausl W., Prager R., Kautzky-Willer A., and Pacini G. Mode of action of Iipomoea batatas (Caiapo) in type 2 diabetic patients Metabolism 52 2003 875 880
24. Merkel P.A., Simonson D.C., Amiel S.A., Plewe G., Sherwin R.S., and Pearson H.A. Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion N Engl J Med 318 1988 809 814
25. Mendler M.H., Turlin B., Moirand R., Jouanolle A.M., Sapey T., and Guyader D. Insulin resistance-associated hepatic iron overload Gastroenterology 117 1999 1155 1163
26. Wolff S.P. Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications Br Med Bull 49 1993 642 652
27. Andrews N.C. Disorders of iron metabolism N Engl J Med 341 1999 1986 1995
28. Beard J.L. Iron biology in immune function, muscle metabolism and neuronal functioning J Nutr 131 2001 568S 579S
29. Oberley L.W. Free radicals and diabetes Free Radic Biol Med 5 1988 113 124
30. Wilson J.G., Lindquist J.H., Grambow S.C., Crook E.D., and Maher J.F. Potential role of increased iron stores in diabetes Am J Med Sci 325 2003 332 339
31. Delvecchio M., and Cavallo L. Growth and endocrine function in thalassemia major in childhood and adolescence J Endocrinol Invest 33 2010 61 68
32. Adams P.C., and Barton J.C. Haemochromatosis Lancet 370 2007 1855 1860
33. Pietrangelo A. Hemochromatosis: an endocrine liver disease Hepatology 46 2007 1291 1301