Ipomoea obscura ameliorates cyclophosphamide induced toxicity by modulating the immune system and levels of proinflammatory cytokine and GSH

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 11, 2010, Pages 1042-1053

  Hamsa, T P ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Chemoprotection; Cyclophosphamide; Ipomoea obscura; Myelosuppression; Proinflammatory cytokine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CYCLOPHOSPHAMIDE; CYTOKINE; GAMMA INTERFERON; GLUTATHIONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; IPOMOEA OBSCURA EXTRACT; LIPID PEROXIDASE; PLANT EXTRACT; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD TOXICITY; BODY WEIGHT; BONE MARROW CELL; BONE MARROW SUPPRESSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; IMMUNOMODULATION; INTESTINE; IPOMOEA; IPOMOEA OBSCURA; LEUKOCYTE COUNT; LIPID PEROXIDATION; LIVER; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; ORGAN WEIGHT; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BONE MARROW CELLS; CYCLOPHOSPHAMIDE; CYTOKINES; GLUTATHIONE; IMMUNE SYSTEM; IPOMOEA; JEJUNUM; LIVER; MALE; MICE; ORGAN SIZE; PLANT EXTRACTS;

CHEMOPROTECTION; CYCLOPHOSPHAMIDE; IPOMOEA OBSCURA; MYELOSUPPRESSION; PROINFLAMMATORY CYTOKINES;

ANIMALS; ANTHROPOMETRY; BLOOD; LIVER; PHOSPHATASES;

TOXICITY;

EID: 78549280224     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y10-086     Document Type: Article

References (47)

1. Abdulaev, F.I. 1993. Plant-derived agents against cancer. In Pharmacology and therapeutics in the new millennium. Edited by S.K. Gupta (Editor). Narosa Publishing House, New Delhi, India. pp. 345-354.
2. Abraham, P., Wilfred, G., and Cathrine. 1999. Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication. Clin. Chim. Acta, 289(1-2): 177-179. doi:10.1016/S0009-8981(99)00140-0. PMID: 10636716.
3. Ainsworth, E.J. 1988. From endotoxins to newer immunomodulators: survival-promoting effects of microbial polysaccharide complexes in irradiated animals. Pharmacol. Ther. 39(1-3): 223-241. doi:10.1016/0163-7258(88)90066-6. PMID:3059368.
4. Alexeeff, G.V., Broadwin, R., Liaw, J., and Dawson, S.V. 2002. Characterization of the LOAEL-to-NOAEL uncertainty factor for mild adverse effects from acute inhalation exposures. Regul. Toxicol. Pharmacol. 36(1): 96-105. doi:10.1006/rtph.2002.1562. PMID:12383722.
5. Ansari, R.A., Tripathi, S.C., Patnaik, G.K., and Dhawan, B.N. 1991. Antihepatotoxic properties of picroliv: an active fraction from rhizomes of Picrorhiza kurrooa. J. Ethnopharmacol. 34(1): 61-68. doi:10.1016/0378-8741(91)90189-K. PMID:1753788.
6. Bancroft, J.D., and Cook, H.F. 1984. Manual of histologic technique. Churchill Livingstone, London, UK. pp. 171-74.
7. Bergmeyer, H.U., and Bernt, E. 1980. Colorimentic methods for aspartate and alanine aminotranferases. In Practical clinical biochemistry. Edited by H. Varley, A.H. Gowenlock, and M. Bell. William Heinemann Medical Books, London, UK. pp. 741-742.
8. Castillo, J., Benavente-García, O., Lorente, J., Alcaraz, M., Redondo, A., Ortuño, A., and Del Rio, J.A. 2000. Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (procyanidins) from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds. J. Agric. Food Chem. 48(5): 1738-1745. doi:10.1021/jf990665o. PMID:10820088.
9. Colvin, M., Padgett, C.A., and Fenselau, C. 1973. A biologically active metabolite of cyclophosphamide. Cancer Res. 33(4): 915-918. PMID:4696485.
10. Danial, N.N., and Korsmeyer, S.J. 2004. Cell death: critical control points. Cell, 116(2): 205-219. doi:10.1016/S0092-8674(04) 00046-7. PMID:14744432.
11. Dhanasekaran, M., Baskar, A.A., Ignacimuthu, S., Agastian, P., and Duraipandiyan, V. 2009. Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. Invest. New Drugs, 27(4): 347-355. doi:10.1007/s10637-008-9181-9. PMID: 18853103.
12. Díaz-Fernández, C., Sanz, N., and Cascales, M. 1996. Changes in glucose-6-phosphate dehydrogenase and malic enzyme gene expression in acute hepatic injury induced by thioacetamide. Biochem. Pharmacol. 51(9): 1159-1163. doi:10.1016/0006-2952(96) 00030-5. PMID:8645338.
13. Dunlop, R.J., and Campbell, C.W. 2000. Cytokines and advanced cancer. J. Pain Symptom Manage. 20(3): 214-232. doi:10.1016/ S0885-3924(00)00199-8. PMID:11018340.
14. Fosberg, F.R., and Sachet, M.H. 1977. Convolvulaceae. Flora of Micronesia, Part 3. Smithsonian Contrib. Bot. 36: 1-34.
15. Gardner, R.V. 1998. Interferon-gamma (IFN-g) as a potential radio and chemo-protectant. Am. J. Hematol. 58(3): 218-223. doi:10. 1002/(SICI)1096-8652(199807)58:3<218::AID-AJH10>3.0. CO;2-5. PMID:9662274.
16. Griffin, J.D. 1988. Clinical applications of colony-stimulating factors. Oncology (Williston Park), 2(1): 15-23. PMID:3079316.
17. Hamasaki, V.K., and Vokes, E.E. 1995. Interferons and other cytokines in head and neck cancer. Med. Oncol. 12(1): 23-33. doi:10.1007/BF01571405. PMID:8542243.
18. Hamsa, T.P., and Kuttan, G. 2008. Ipomoea obscura (L.) enhances the functions of immunological effector cells, inhibits proinflammatory cytokines and nitric oxide production by LPS induced macrophages. Immunopharmacol. Immunotoxicol. 16: 1-15.
19. Hatono, S., Jimenez, A., and Wargovich, M.J. 1996. Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase. Carcinogenesis, 17(5): 1041-1044. doi:10.1093/carcin/17.5.1041. PMID:8640910.
20. Hersh, E. 1982. Immunological approaches to cancer therapeutics. John Wiley and Sons, New York, N.Y.
21. Jemal, A., Tiwari, R.C., Murray, T., Ghafoor, A., Samuels, A., Ward, E., et al. 2004. Cancer statistics, 2004. Ca-Cancer J. Clin. 54(1): 8-29. doi:10.3322/canjclin.54.1.8. PMID:14974761.
22. King, E.J., and Amstrong, A.R. 1980. Method of King and Amstrong. In Practical clinical biochemistry. Edited by H. Varley, A.H. Gowenlock, and M. Bell. William Heinemann Medical Books, London, UK. pp. 897-899.
23. Kirtikar, K.R., and Basu, B.D. 1980. Indian medicinal plants. 2nd ed. Edited by M.P. Singh and B.P. Singh. Jayyed Press, New Delhi, India.
24. Kumar, V., Abbas, A.K., and Fausto, N. 2004. In Robbins and Cotran pathologic basis of disease. 7th ed. Edited by V. Kumar, N. Fausto, and A. Abbas. Saunders, Philadelphia, Pa. pp. 828-830.
25. Kurose, I., Higuchi, H., Miura, S., Saito, H., Watanabe, N., Hokari, R., et al. 1997. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. Hepatology, 25(2): 368-378. doi:10.1002/hep.510250219. PMID:9021949.
26. Latorre, A.O., Hueza, I.M., and Górniak, S.L. 2007. Association of Ipomoea carnea and BCG reduces birth defects caused by cyclophosphamide in rats. Life Sci. 80(5): 430-435. doi:10.1016/j. lfs.2006.09.033. PMID:17070555.
27. Ma, Q., and Kinneer, K. 2002. Chemoprotection by phenolic antioxidants. Inhibition of tumor necrosis factor a induction in macrophages. J. Biol. Chem. 277(4): 2477-2484. doi:10.1074/ jbc.M106685200. PMID:11694529.
28. Masella, R., Varì, R., D'Archivio, M., Di Benedetto, R., Matarrese, P., Malorni, W., et al. 2004. Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J. Nutr. 134(4): 785-791. PMID:15051826.
29. Moron, M.S., Depierre, J.W., and Mannervik, B. 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim. Biophys. Acta, 582(1): 67-78. PMID:760819.
30. Murray, R.L. 1984. Nonprotein compounds in clinical chemistry: theory, analysis and corelation. In Clinical chemistry. Edited by L.A. Kaplan and A.J. Pesce. C.V. Mosby, Toronto, Ont. pp. 1230-1268.
31. Myzak, M.C., and Dashwood, R.H. 2006. Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett. 233(2): 208-218. doi:10.1016/j.canlet.2005.02.033. PMID:16520150.
32. Neta, R. 1990. Radioprotection and therapy of radiation injury with cytokines. Prog. Clin. Biol. Res. 352: 471-478. PMID:2205873.
33. Ohkawa, H., Ohishi, N., and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95(2): 351-358. doi:10.1016/0003-2697(79)90738-3. PMID:36810.
34. Paula, A.C., Hayashi, L.S., and Freitas, J.C. 2003. Anti-inflammatory and antispasmodic activity of Ipomoea imperati (Vahl) Griseb (Convolvulaceae). Braz. J. Med. Biol. Res. 36(1): 105-112. doi:10.1590/S0100-879X2003000100014. PMID:12532233.
35. Pongprayoon, U., Baeckstrom, P., Jacobsson, U., Lindstrom, M., x and Bohlin, L. 1992. Antispasmodic activity of b-damascenone and E-phytol isolated from Ipomoea pes-caprae. Planta Med. 58(1): 19-21. doi:10.1055/s-2006-961381. PMID:1620738.
36. Salvadori, D.M., Ribeiro, L.R., Xiao, Y., Boei, J.J., and Natarajan, A.T. 1996. Radioprotection of b-carotene evaluated on mouse somatic and germ cells. Mutat. Res. 356(2): 163-170. PMID: 8841481.
37. Samir, M., and el Kholy, N.M. 1999. Thiobarbituric acid reactive substances in patients with laryngeal cancer. Clin. Otolaryngol. Allied Sci. 24(3): 232-234. doi:10.1046/j.1365-2273.1999. 00249.x. PMID:10384852.
38. Seven, A., Civelek, S., Inci, E., Inci, F., Korkut, N., and Burçak, G. 1999. Evaluation of oxidative stress parameters in blood of patients with laryngeal carcinoma. Clin. Biochem. 32(5): 369-373. doi:10.1016/S0009-9120(99)00022-3. PMID:10480452.
39. Talalay, P., Fahey, J.W., Holtzclaw, W.D., Prestera, T., and Zhang, Y. 1995. Chemoprotection against cancer by phase 2 enzyme induction. Toxicol. Lett. 82-83: 173-179. doi:10.1016/0378-4274(95)03553-2.
40. Thèze, J., Alzari, P.M., and Bertoglio, J. 1996. Interleukin 2 and its receptors: recent advances and new immunological functions. Immunol. Today, 17(10): 481-486. doi:10.1016/0167-5699(96) 10057-C. PMID:8908814.
41. Thresiamma, K.C., George, J., and Kuttan, R. 1996. Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity. Indian J. Exp. Biol. 34(9): 845-847. PMID:9014516.
42. Torkelson, A.R., LaBudde, J.A., and Weikel, J.H., Jr. 1974. The metabolic fate of cyclophosphamide. Drug Metab. Rev. 3(1): 131-165. doi:10.3109/03602537408993740. PMID:4214687.
43. Toro, G., and Ackermann, P.G. 1975. Practical clinical chemistry. Little Brown and Co., Boston, Mass.
44. Wooster, R., and Weber, B.L. 2003. Breast and ovarian cancer. N. Engl. J. Med. 348(23): 2339-2347. doi:10.1056/NEJMra012284. PMID:12788999.
45. Yang, C.S., Landau, J.M., Huang, M.T., and Newmark, H.L. 2001. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21(1): 381-406. doi:10.1146/annurev.nutr.21. 1.381. PMID:11375442.
46. Yarmonenko, S.P. 1998. Radiobiology of humans and animals. Mir Publishers, Moscow, Russia.
47. Zaidi, S.I., Singh, K.P., Raisuddin, S., Saxena, A.K., and Ray, P.K. 1990. Protein A induced abrogation of cyclophosphamide toxicity is associated with concomitant potentiation of immune function of host. Immunopharmacol. Immunotoxicol. 12(3): 479-512. doi:10.3109/08923979009006474. PMID:2266232.