NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth

Investigational New Drugs

Volumn 28, Issue 6, 2010, Pages 729-743

  Papaioannou, Maria ^a   Schleich, Sonja ^b   Roell, Daniela ^a   Schubert, Undine ^a   Tanner, Tamzin ^c   Claessens, Frank ^c   Matusch, Rudolf ^b   Baniahmad, Aria ^a,d  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Androgen receptor; Antihormone; N butylbenzene sulfonamide; Natural compound; Prostate cancer; Pygeum africanum

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOCORTICOID RECEPTOR; N BUTYLBENZENE SULFONAMIDE; PROGESTERONE RECEPTOR; PROSTATE SPECIFIC ANTIGEN; PYGEUM AFRICANUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BARK; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROSTATITIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION;

ANDROGEN ANTAGONISTS; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; HUMANS; LIGANDS; MALE; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PYGEUM; RECEPTORS, ANDROGEN; RECEPTORS, PROGESTERONE; SULFONAMIDES; TRANSCRIPTION, GENETIC;

EID: 78549270817     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9304-y     Document Type: Article

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