-
1
-
-
10744229294
-
Lamin a truncation in Hutchinson-Gilford progeria
-
10.1126/science.1084125, 12702809
-
De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M, et al. Lamin a truncation in Hutchinson-Gilford progeria. Science 2003, 300(5628):2055. 10.1126/science.1084125, 12702809.
-
(2003)
Science
, vol.300
, Issue.5628
, pp. 2055
-
-
De Sandre-Giovannoli, A.1
Bernard, R.2
Cau, P.3
Navarro, C.4
Amiel, J.5
Boccaccio, I.6
Lyonnet, S.7
Stewart, C.L.8
Munnich, A.9
Le Merrer, M.10
-
2
-
-
0001254975
-
Progeria: a form of senilism
-
H G. Progeria: a form of senilism. Practitioner 1904, 73:188-217.
-
(1904)
Practitioner
, vol.73
, pp. 188-217
-
-
H, G.1
-
3
-
-
33845269544
-
Hutchinson-Gilford progeria syndrome: review of the phenotype
-
Hennekam RC. Hutchinson-Gilford progeria syndrome: review of the phenotype. Am J Med Genet A 2006, 140(23):2603-2624.
-
(2006)
Am J Med Genet A
, vol.140
, Issue.23
, pp. 2603-2624
-
-
Hennekam, R.C.1
-
4
-
-
0036578920
-
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
-
Pendas AM, Zhou Z, Cadinanos J, Freije JM, Wang J, Hultenby K, Astudillo A, Wernerson A, Rodriguez F, Tryggvason K, et al. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet 2002, 31(1):94-99.
-
(2002)
Nat Genet
, vol.31
, Issue.1
, pp. 94-99
-
-
Pendas, A.M.1
Zhou, Z.2
Cadinanos, J.3
Freije, J.M.4
Wang, J.5
Hultenby, K.6
Astudillo, A.7
Wernerson, A.8
Rodriguez, F.9
Tryggvason, K.10
-
5
-
-
33845699084
-
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
-
10.1242/jcs.03263, 17062639
-
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci 2006, 119(Pt 22):4644-4649. 10.1242/jcs.03263, 17062639.
-
(2006)
J Cell Sci
, vol.119
, Issue.PT 22
, pp. 4644-4649
-
-
Liu, Y.1
Rusinol, A.2
Sinensky, M.3
Wang, Y.4
Zou, Y.5
-
6
-
-
25644440744
-
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
-
10.1038/nature04019, 16079796
-
Varela I, Cadinanos J, Pendas AM, Gutierrez-Fernandez A, Folgueras AR, Sanchez LM, Zhou Z, Rodriguez FJ, Stewart CL, Vega JA, et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 2005, 437(7058):564-568. 10.1038/nature04019, 16079796.
-
(2005)
Nature
, vol.437
, Issue.7058
, pp. 564-568
-
-
Varela, I.1
Cadinanos, J.2
Pendas, A.M.3
Gutierrez-Fernandez, A.4
Folgueras, A.R.5
Sanchez, L.M.6
Zhou, Z.7
Rodriguez, F.J.8
Stewart, C.L.9
Vega, J.A.10
-
7
-
-
22544466685
-
Genomic instability in laminopathy-based premature aging
-
10.1038/nm1266, 15980864
-
Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, et al. Genomic instability in laminopathy-based premature aging. Nat Med 2005, 11(7):780-785. 10.1038/nm1266, 15980864.
-
(2005)
Nat Med
, vol.11
, Issue.7
, pp. 780-785
-
-
Liu, B.1
Wang, J.2
Chan, K.M.3
Tjia, W.M.4
Deng, W.5
Guan, X.6
Huang, J.D.7
Li, K.M.8
Chau, P.Y.9
Chen, D.J.10
-
8
-
-
0030595677
-
Genomic instability, mutators, and the development of cancer: is there a role for p53?
-
10.1093/jnci/88.22.1608, 8931599
-
Fishel R. Genomic instability, mutators, and the development of cancer: is there a role for p53?. J Natl Cancer Inst 1996, 88(22):1608-1609. 10.1093/jnci/88.22.1608, 8931599.
-
(1996)
J Natl Cancer Inst
, vol.88
, Issue.22
, pp. 1608-1609
-
-
Fishel, R.1
-
9
-
-
0032542364
-
Genetic instabilities in human cancers
-
10.1038/25292, 9872311
-
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998, 396(6712):643-649. 10.1038/25292, 9872311.
-
(1998)
Nature
, vol.396
, Issue.6712
, pp. 643-649
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
10
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging
-
10.1126/science.1127168, 1855250, 16645051
-
Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006, 312(5776):1059-1063. 10.1126/science.1127168, 1855250, 16645051.
-
(2006)
Science
, vol.312
, Issue.5776
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
11
-
-
35948961894
-
Human pregnane X receptor and resistance to chemotherapy in prostate cancer
-
10.1158/0008-5472.CAN-06-4758, 17974979
-
Chen Y, Tang Y, Wang MT, Zeng S, Nie D. Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Cancer Res 2007, 67(21):10361-10367. 10.1158/0008-5472.CAN-06-4758, 17974979.
-
(2007)
Cancer Res
, vol.67
, Issue.21
, pp. 10361-10367
-
-
Chen, Y.1
Tang, Y.2
Wang, M.T.3
Zeng, S.4
Nie, D.5
-
12
-
-
0041423293
-
Nuclear envelope irregularity is induced by RET/PTC during interphase
-
1868259, 12937150
-
Fischer AH, Taysavang P, Jhiang SM. Nuclear envelope irregularity is induced by RET/PTC during interphase. Am J Pathol 2003, 163(3):1091-1100. 1868259, 12937150.
-
(2003)
Am J Pathol
, vol.163
, Issue.3
, pp. 1091-1100
-
-
Fischer, A.H.1
Taysavang, P.2
Jhiang, S.M.3
-
13
-
-
0035156249
-
Nuclear envelope organization in papillary thyroid carcinoma
-
Fischer AH, Taysavang P, Weber CJ, Wilson KL. Nuclear envelope organization in papillary thyroid carcinoma. Histol Histopathol 2001, 16(1):1-14.
-
(2001)
Histol Histopathol
, vol.16
, Issue.1
, pp. 1-14
-
-
Fischer, A.H.1
Taysavang, P.2
Weber, C.J.3
Wilson, K.L.4
-
14
-
-
2942643923
-
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
-
10.1073/pnas.0402943101, 428455, 15184648
-
Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, et al. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 2004, 101(24):8963-8968. 10.1073/pnas.0402943101, 428455, 15184648.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.24
, pp. 8963-8968
-
-
Goldman, R.D.1
Shumaker, D.K.2
Erdos, M.R.3
Eriksson, M.4
Goldman, A.E.5
Gordon, L.B.6
Gruenbaum, Y.7
Khuon, S.8
Mendez, M.9
Varga, R.10
-
15
-
-
17644373758
-
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
-
10.1038/nm1204, 1351119, 15750600
-
Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med 2005, 11(4):440-445. 10.1038/nm1204, 1351119, 15750600.
-
(2005)
Nat Med
, vol.11
, Issue.4
, pp. 440-445
-
-
Scaffidi, P.1
Misteli, T.2
-
16
-
-
0034069237
-
Cancer, aging and cellular senescence
-
Campisi J. Cancer, aging and cellular senescence. In Vivo 2000, 14(1):183-188.
-
(2000)
In Vivo
, vol.14
, Issue.1
, pp. 183-188
-
-
Campisi, J.1
-
17
-
-
0031007155
-
Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?
-
Wang Y, Perrault AR, Iliakis G. Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?. Cancer Res 1997, 57(9):1654-1659.
-
(1997)
Cancer Res
, vol.57
, Issue.9
, pp. 1654-1659
-
-
Wang, Y.1
Perrault, A.R.2
Iliakis, G.3
-
18
-
-
0034576494
-
The many substrates and functions of ATM
-
10.1038/35043058, 11252893
-
Kastan MB, Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol 2000, 1(3):179-186. 10.1038/35043058, 11252893.
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, Issue.3
, pp. 179-186
-
-
Kastan, M.B.1
Lim, D.S.2
-
19
-
-
0842308792
-
Measurements using the alkaline comet assay predict bladder cancer cell radiosensitivity
-
10.1038/sj.bjc.6601333, 2395287, 14676805
-
Moneef MA, Sherwood BT, Bowman KJ, Kockelbergh RC, Symonds RP, Steward WP, Mellon JK, Jones GD. Measurements using the alkaline comet assay predict bladder cancer cell radiosensitivity. Br J Cancer 2003, 89(12):2271-2276. 10.1038/sj.bjc.6601333, 2395287, 14676805.
-
(2003)
Br J Cancer
, vol.89
, Issue.12
, pp. 2271-2276
-
-
Moneef, M.A.1
Sherwood, B.T.2
Bowman, K.J.3
Kockelbergh, R.C.4
Symonds, R.P.5
Steward, W.P.6
Mellon, J.K.7
Jones, G.D.8
-
20
-
-
0025773554
-
Mutator phenotype may be required for multistage carcinogenesis
-
Loeb LA. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 1991, 51(12):3075-3079.
-
(1991)
Cancer Res
, vol.51
, Issue.12
, pp. 3075-3079
-
-
Loeb, L.A.1
-
21
-
-
0022519369
-
The nuclear lamina is a meshwork of intermediate-type filaments
-
10.1038/323560a0, 3762708
-
Aebi U, Cohn J, Buhle L, Gerace L. The nuclear lamina is a meshwork of intermediate-type filaments. nature 1986, 323:560-564. 10.1038/323560a0, 3762708.
-
(1986)
nature
, vol.323
, pp. 560-564
-
-
Aebi, U.1
Cohn, J.2
Buhle, L.3
Gerace, L.4
-
22
-
-
46249086799
-
Premature aging in mice activates a systemic metabolic response involving autophagy induction
-
10.1093/hmg/ddn120, 18443001
-
Marino G, Ugalde AP, Salvador-Montoliu N, Varela I, Quiros PM, Cadinanos J, van der Pluijm I, Freije JM, Lopez-Otin C. Premature aging in mice activates a systemic metabolic response involving autophagy induction. Hum Mol Genet 2008, 17(14):2196-2211. 10.1093/hmg/ddn120, 18443001.
-
(2008)
Hum Mol Genet
, vol.17
, Issue.14
, pp. 2196-2211
-
-
Marino, G.1
Ugalde, A.P.2
Salvador-Montoliu, N.3
Varela, I.4
Quiros, P.M.5
Cadinanos, J.6
van der Pluijm, I.7
Freije, J.M.8
Lopez-Otin, C.9
-
23
-
-
34249863298
-
Autophagy suppresses tumor progression by limiting chromosomal instability
-
10.1101/gad.1545107, 1877749, 17510285
-
Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007, 21(11):1367-1381. 10.1101/gad.1545107, 1877749, 17510285.
-
(2007)
Genes Dev
, vol.21
, Issue.11
, pp. 1367-1381
-
-
Mathew, R.1
Kongara, S.2
Beaudoin, B.3
Karp, C.M.4
Bray, K.5
Degenhardt, K.6
Chen, G.7
Jin, S.8
White, E.9
-
24
-
-
30844434561
-
Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis
-
10.1194/jlr.R500011-JLR200, 16207929
-
Young SG, Fong LG, Michaelis S. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis. J Lipid Res 2005, 46(12):2531-2558. 10.1194/jlr.R500011-JLR200, 16207929.
-
(2005)
J Lipid Res
, vol.46
, Issue.12
, pp. 2531-2558
-
-
Young, S.G.1
Fong, L.G.2
Michaelis, S.3
-
25
-
-
24644520772
-
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
-
10.1073/pnas.0506001102, 1200293, 16129833
-
Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 2005, 102(36):12879-12884. 10.1073/pnas.0506001102, 1200293, 16129833.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.36
, pp. 12879-12884
-
-
Capell, B.C.1
Erdos, M.R.2
Madigan, J.P.3
Fiordalisi, J.J.4
Varga, R.5
Conneely, K.N.6
Gordon, L.B.7
Der, C.J.8
Cox, A.D.9
Collins, F.S.10
-
26
-
-
0035132538
-
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
-
End DW, Smets G, Todd AV, Applegate TL, Fuery CJ, Angibaud P, Venet M, Sanz G, Poignet H, Skrzat S, et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res 2001, 61(1):131-137.
-
(2001)
Cancer Res
, vol.61
, Issue.1
, pp. 131-137
-
-
End, D.W.1
Smets, G.2
Todd, A.V.3
Applegate, T.L.4
Fuery, C.J.5
Angibaud, P.6
Venet, M.7
Sanz, G.8
Poignet, H.9
Skrzat, S.10
-
27
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, Rosen N. A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 1995, 55(22):5302-5309.
-
(1995)
Cancer Res
, vol.55
, Issue.22
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
Kohl, N.E.4
Gibbs, J.B.5
Oliff, A.6
Rosen, N.7
|