Nuclear envelope irregularity is induced by RET/PTC during interphase

American Journal of Pathology

Volumn 163, Issue 3, 2003, Pages 1091-1100

  Fischer, Andrew H ^a,c   Taysavang, Panya ^a   Jhiang, Sissy M ^b  

^a EMORY UNIVERSITY HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN; LAMIN; LEUCINE ZIPPER PROTEIN; PROTEIN RET;

ARTICLE; CANCER DIAGNOSIS; CELL NUCLEUS MEMBRANE; CELL SHAPE; CONTROLLED STUDY; DIMERIZATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERPHASE; MICROINJECTION; MITOSIS; ONCOGENE H RAS; ONCOGENE RET; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYROID PAPILLARY CARCINOMA;

EID: 0041423293     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63468-2     Document Type: Article

References (61)

1. Aitchison JD, Rout MP: A tense time for the nuclear envelope. Cell 2002, 108:301-304
2. Hutchison CJ, Alvarez-Reyes M, Vaughan OA: Lamins in disease: why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes? J Cell Sci 2001, 114:9-19
3. Fischer AH, Taysavang P, Weber C, Wifson K: Nuclear envelope organization in papillary thyroid carcinoma. Histol Histopathol 2001, 16:1-14
4. Wilson KL: The nuclear envelope, muscular dystrophy, and gene Trends Cell Biol 2000, 10:125-129
5. Worman HJ, Courvalin JC: The inner nuclear membrane J Membr Biol 2000, 177:1-11
6. Moir RD, Spann TP, Goldman RD: The dynamic properties and possible functions of nuclear lamins. Int Rev Cytol 1995, 162B:141-182
7. Ryan KJ, Wente SR: The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm. Curr Opin Cell Biol 2000, 12:361-371
8. Newport JW, Wilson KL, Dunphy WG: A lamin-independent pathway for nuclear envelope assembly. J Cell Biol 1990, 111:2247-2259
9. Spann TP, Moir RD, Goldman AE, Stick R, Goldman RD: Disruption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis. J Cell Biol 1997, 136:1201-1212
10. Goldberg M, Jenkins H, Allen T, Whitfield WG, Hutchison CJ: Xenopus lamin B3 has a direct role in the assembly of a replication-competent nucleus: evidence from cell-free egg extracts J Cell Sci 1995, 108:3451-3461
11. Hutchison CJ, Bridger JM, Cox LS, Kill IR: Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication. Journal of Cell Science 1994, 107:3259-3269
12. Yang L, Guan T, Gerace L: Lamin-binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase. J Cell Biol 1997, 139:1077-1087
13. Gant TM, Harris CA, Wilson KL: Roles of LAP2 proteins in nuclear assembly and DNA replication: truncated LAP2B proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts. J Cell Biol 1999, 144:1083-1096
14. Moir RD, Spann TP, Herrmann H, Goldman RD: Disruption of nuclear lamin organization blocks the elongation phase of DNA replication J Cell Biol 2000, 149:1179-1192
15. Ye Q, Callebaut I, Pezhman A, Courvalin JC, Worman HJ: Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. J Biol Chem 1997, 272:14983-14989
16. Cockell M, Gasser SM: Nuclear compartments and gene regulation. Curr Opin Genet Dev 1999, 9:199-205
17. Kosak ST, Skok JA, Medina KL, Riblet R, Le Beau MM, Fisher AG, Singh H: Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 2002, 296:158-162
18. Matioli GT: Mechanics of nucleocytoplasmic exchanges mediated by vertebrates' nuclear pore complex. Med Hypotheses 2000, 54:30-32
19. Gant TM, Wilson KL: Nuclear assembly. Ann Rev Cell Dev Biol 1997, 13:669-695
20. Rosai J, Carcangiu ML, DeLellis RA: Tumors of the Thyroid Gland. Washington, Armed Forces Institute of Pathology, 1992, pp 343
21. Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G: PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 1990, 60:557-563
22. Santoro M, Sabino N, Ishizaka Y, Ushijima T, Carlomagno F, Cerrato A, Grieco M, Battaglia C, Martelli ML, Paulin C, Fabien N, Sugimura T, Fusco A, Nagao M: Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours. Br J Cancer 1993, 68:460-464
23. Viglietto G, Chiappetta G, Martinez-Tello FJ, Fukunaga FH, Tallini G, Rigopoulou D, Visconti R, Mastro A, Santoro M, Fusco A: RET/PTC oncogene activation is an early event in thyroid carcinogenesis. Oncogene 1995, 11:1207-1210
24. Fischer AH, Bond JA, Taysavang P, Battles OE, Wynford-Thomas D: Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure. Am J Pathol 1998, 153:1443-1450
25. Fusco A, Chiappetta G, Hui P, Garcia-Rostan G, Golden L, Kinder BK, Dilion DA, Giuliano A, Cirafici AM, Santoro M, Rosai J, Tallini G: Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer. Am J Pathol 2002, 160:2157-2167
26. Wynford-Thomas D: Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms. Horm Res 1997, 47:145-157
27. Fischer AH, Chaddee DN, Wright JA, Gansler TS, Davie JR: Ras-associated nuclear structural change appears functionally significant and independent of the mitotic signaling pathway. J Cell Biochem 1998, 70:130-140
28. Bond JA, Wyllie FS, Rowson J, Radulescu A, Wynford-Thomas D: In vitro reconstruction of tumour initiation in a human epithelium. Oncogene 1994, 9:281-290
29. Xing S, Furminger TL, Tong Q, Jhiang SM: Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells. J Biol Chem 1998, 273:4909-4914
30. Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L, Wigler MH, Der CJ: Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation Mol Cell Biol 1996, 16:3923-3933
31. Bar-Sagi D: Mammalian cell microinjection assay. Methods Enzymol 1995, 255:436-442
32. Rosorius O, Reichart B, Kratzer F, Heger P, Dabauvalle MC, Hauber J: Nuclear pore localization and nucleocytoplasmic transport of elF-5A: evidence for direct interaction with the export receptor CRM1. J Cell Sci 1999, 112:2369-2380
33. Guan T, Kehlenbach RH, Schirmer EC, Kehlenbach A, Fan F, Clurman BE, Arnheim N, Gerace L: Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. Mol Cell Biol 2000, 20:5619-5630
34. Iovine MK, Wente SR: A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p. J Cell Biol 1997, 137:797-811
35. Ellenberg J, Siggia ED, Moreira JE, Smith CL, Presley JF, Worman HJ, Lippincott-Schwartz J: Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis. J Cell Biol 1997, 138:1193-1206
36. Melillo RM, Santoro M, Ong SH, Billaud M, Fusco A, Hadari YR, Schlessinger J, Lax I: Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol 2001, 21:4177-4187
37. Mercalli E, Ghizzoni S, Arighi E, Alberti L, Sangregorio R, Radice MT, Gishizky ML, Pierotti MA, Borrello MG: Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein. Oncogene 2001, 20:3475-3485
38. Grigoryev SA, Woodcock CL: Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT). J Biol Chem 1998, 273:3082-3089
39. Rando OJ, Zhao K, Crabtree GR: Searching for a function for nuclear actin. Trends Cell Biol 2000, 10;92-97
40. Waldman T, Lengauer C, Kinzler KW, Vogelstein B: Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996, 381:713-716
41. Shimizu N, Itoh N, Utiyama H, Wahl GM: Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J Cell Biol 1998, 140:1307-1320
42. Fricker M, Hollinshead M, White N, Vaux D: Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol 1997, 136:531-544
43. Belmont AS: Visualizing chromosome dynamics with GFP. Trends Cell Biol 2001, 11:250-257
44. Maniotis AJ, Chen CS, Ingber DE: Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci USA 1997, 94:849-854
45. Salina D, Bodoor K, Eckley DM, Schroer TA, Rattner JB, Burke B: Cytoplasmic dynein as a facilitator of nuclear envelope breakdown. Cell 2002, 108:97-107
46. Beaudouin J, Gerlich D, Daigle N, Eils R, Ellenberg J: Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina. Cell 2002, 108:83-96
47. Sarria AJ, Lieber JG, Nordeen SK, Evans RM: The presence or absence of a vimentin-type intermediate filament network affects the shape of the nucleus in human SW-13 cells. J Cell Sci 1994, 107:1593-1607
48. Holwell TA, Schweitzer SC, Evans RM: Tetracycline-regulated expression of vimentin in fibroblasts derived from vimentin null mice. J Cell Sci 1997, 110:1947-1956
49. Kamei H: Relationship of nuclear invaginations to perinuclear rings composed of intermediate filaments in MIA PaCa-2 and some other cells. Cell Struct Funct 1994, 19:123-132
50. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A: The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 1992, 70:401-410
51. Broers JL, Machiels BM, van Eys GJ, Kuijpers HJ, Manders EM, van Driel R, Ramaekers FC: Dynamics of the nuclear lamina as monitored by GFP-tagged A-type lamins. J Cell Sci 1999, 112:3463-3475
52. Giardina C, Caniglia DM, D'Aprile M, Lettini T, Serio G, Cipriani T, Ricco R, Pesce Delfino V: Nuclear morphometry in squamous cell carcinoma (SCC) of the tongue. Eur J Cancer B Oral Oncol 1996, 32B:91-96
53. Seker H, Odetayo MO, Petrovic D, Naguib RN, Bartoli C, Alasio L, Lakshmi MS, Sherbet GV: Assessment of nodal involvement and survival analysis in breast cancer patients using image cytometric data: statistical, neural network and fuzzy approaches. Anticancer Research 2002, 22:433-438
54. Nativ O, Sabo E, Bejar J, Halachmi S, Moskovitz B, Miselevich I: A comparison between histological grade and nuclear morphometry for predicting the clinical outcome of localized renal cell carcinoma. Br J Urol 1996, 78:33-38
55. Borland RN, Partin AW, Epstein JI, Brendler CB: The use of nuclear morphometry in predicting recurrence of transitional cell carcinoma. J Urol 1993, 149:272-275
56. Epstein JI, Berry SJ, Eggleston JC: Nuclear roundness factor: a predictor of progression in untreated Stage A2 prostate cancer. Cancer 1984, 54:1666-1671
57. Mohler JL, Figlesthaler WM, Zhang XZ, Partin AW, Maygarden SJ: Nuclear shape analysis for the assessment of local invasion and metastases in clinically localized prostate carcinoma Cancer 1994, 74:2996-3001
58. Partin AW, Steinberg GD, Pitcock RV, Wu L, Piantadosi S, Coffey DS, Epstein JI: Use of nuclear morphometry, gleason histologic scoring, clinical stage, and age to predict disease-free survival among patients with prostate cancer. Cancer 1992, 70:161-168
59. Liu CQ, Sasaki H, Fahey MT, Sakamoto A, Sato S, Tanaka T: Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. Br J Cancer 1999, 79:1736-1741
60. Gurley AM, Hidvegi DF, Cajulis RS, Bacus S: Morphologic and morphometric features of low-grade serous tumours of the ovary. Diagn Cytopathol 1994, 11:220-225
61. Ettler HC, Joseph MG, Downing PA, Suskin NG, Wright VC: Atypical squamous cells of undetermined significance: a cytohistological study in a colposcopy clinic. Diagn Cytopathol 1999, 21:211-216