Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 667-674

  Chen, Mei Chih ^a   Wang, Shyi Wu ^b   Kan, Shu Fen ^a   Tsai, Shiow Chwen ^c   Wu, Yu Ching ^a   Wang, Paulus S ^a,d,e  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c UNIVERSITY OF TAIPEI   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

P450SCC; Pregnenolone; PTU; StAR

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); MITOGEN ACTIVATED PROTEIN KINASE; PREGNENOLONE; PROGESTERONE; PROPYLTHIOURACIL; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL STIMULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GRANULOSA CELL; HORMONE SYNTHESIS; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; STEROIDOGENESIS; UPREGULATION;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CELL EXTRACTS; CELL FRACTIONATION; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; ENZYME INHIBITORS; FEMALE; FLAVONOIDS; GRANULOSA CELLS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHOPROTEINS; PREGNENOLONE; PROPYLTHIOURACIL; RATS; RATS, SPRAGUE-DAWLEY; STEROIDOGENIC FACTOR 1; UP-REGULATION;

RATTUS;

EID: 78549236170     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq302     Document Type: Article

References (53)

1. Abraham, P., and Acharya, S. (2010). Current and emerging treatment options for Graves′ hyperthyroidism. Ther. Clin. Risk Manag. 6, 29-40.
2. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
3. Chan, W.Y., and Ng, T.B. (1995). Effect of hypothyroidism induced by propylthiouracil and thiourea on male and female reproductive systems of neonatal mice. J. Exp. Zool. 273, 160-169.
4. Chastain, M.A., Russo, G.G., Boh, E.E., Chastain, J.B., Falabella, A., and Millikan, L.E. (1999). Propylthiouracil hypersensitivity: report of two patients with vasculitis and review of the literature. J. Am. Acad. Dermatol. 41, 757-764.
5. Chen, J.J., Wang, P.S., Chien, E.J., and Wang, S.W. (2001). Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells. Br. J. Pharmacol. 132, 1761-1768.
6. Chen, J.J., Wang, S.W., Chien, E.J., and Wang, P.S. (2003). Direct effect of propylthiouracil on progesterone release in rat granulosa cells. Br. J. Pharmacol. 139, 1564-1570.
7. Chen, M.C., Lin, H., Hsu, F.N., Huang, P.H., Lee, G.S., andWang, P.S. (2010). Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells. Am. J. Physiol. Cell Physiol. 299, C516-C27.
8. Chiao, Y.C., Chao, H.L., Huang, S.W., and Wang, P.S. (2000). Direct effects of propylthiouracil on testosterone production in monkeys. Chin. J. Physiol. 43, 55-59.
9. Chiao, Y.C., Cho, W.L., and Wang, P.S. (2002). Inhibition of testosterone production by propylthiouracil in rat Leydig cells. Biol. Reprod. 67, 416-422.
10. Cooper, D.S. (1984). Antithyroid drugs. N. Engl. J. Med. 311, 1353-1362.
11. Cooper, D.S. (2005). Antithyroid drugs. N. Engl. J. Med. 352, 905-917.
12. Deidiker, R., and deMello, D.E. (1996). Propylthiouracil-induced fulminant hepatitis: case report and review of the literature. Pediatr. Pathol. Lab. Med. 16, 845-852.
13. Doufas, A.G., and Mastorakos, G. (2000). The hypothalamic-pituitary-thyroid axis and the female reproductive system. Ann. N.Y. Acad. Sci. 900, 65-76.
14. Gyles, S.L., Burns, C.J., Whitehouse, B.J., Sugden, D., Marsh, P.J., Persaud, S.J., and Jones, P.M. (2001). ERKs regulate cyclic AMP-induced steroid synthesis through transcription of the steroidogenic acute regulatory (StAR) gene. J. Biol. Chem. 276, 34888-34895.
15. Hadley, M.E. (2000). In Endocrinology, 5th ed. Prentice Hall, Upper Saddle River, NJ.
16. Hammer, G.D., Krylova, I., Zhang, Y., Darimont, B.D., Simpson, K., Weigel, N.L., and Ingraham, H.A. (1999). Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol. Cell 3, 521-526.
17. Hanson, J.S. (1984). Propylthiouracil and hepatitis. Two cases and a review of the literature. Arch. Intern. Med. 144, 994-996.
18. Hapon, M.B., Motta, A.B., Ezquer, M., Bonafede, M., and Jahn, G.A. (2007). Hypothyroidism prolongs corpus luteum function in the pregnant rat. Reproduction 133, 197-205.
19. Hapon, M.B., Simoncini, M., Via, G., and Jahn, G.A. (2003). Effect of hypothyroidism on hormone profiles in virgin, pregnant and lactating rats, and on lactation. Reproduction 126, 371-382.
20. Hardy, M.P., Kirby, J.D., Hess, R.A., and Cooke, P.S. (1993). Leydig cells increase their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism. Endocrinology 132, 2417-2420.
21. Hatsuta, M., Abe, K., Tamura, K., Ryuno, T., Watanabe, G., Taya, K., and Kogo, H. (2004). Effects of hypothyroidism on the estrous cycle and reproductive hormones in mature female rat. Eur. J. Pharmacol. 486, 343-348.
22. Hess, R.A., Cooke, P.S., Bunick, D., and Kirby, J.D. (1993). Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers. Endocrinology 132, 2607-2613.
23. Hu, M.C., Guo, I.C., Lin, J.H., and Chung, B.C. (1991). Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein. Biochem. J. 274(Pt 3), 813-817.
24. Hwang, J.J., Lin, S.W., Teng, C.H., Ke, F.C., and Lee, M.T. (1996). Relaxin modulates the ovulatory process and increases secretion of different gelatinases from granulosa and theca-interstitial cells in rats. Biol. Reprod. 55, 1276-1283.
25. Jonas, M.M., and Eidson, M.S. (1988). Propylthiouracil hepatotoxicity: two pediatric cases and review of the literature. J. Pediatr. Gastroenterol. Nutr. 7, 776-779.
26. Joyce, K.L., Porcelli, J., and Cooke, P.S. (1993). Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse. J. Androl. 14, 448-455.
27. Kampmann, J.P., and Molholm Hansen, J.E. (1981). Correlation between antithyroid effect and serum concentrations of propylthiouracil in patients with hyperthyroidism. Br. J. Clin. Pharmacol. 12, 681-686.
28. Kan, S.F., Huang, W.J., Lin, L.C., and Wang, P.S. (2004). Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP. Int. J. Cancer. 110, 641-651.
29. Kan, S.F., Kau, M.M., Low-Tone Ho, L., and Wang, P.S. (2003). Inhibitory effects of bromocriptine on corticosterone secretion in male rats. Eur. J. Pharmacol. 468, 141-149.
30. Krassas, G.E. (2000). Thyroid disease and female reproduction. Fertil. Steril. 74, 1063-1070.
31. Kuo, H.S., Hsu, F.N., Chiang, M.C., You, S.C., Chen, M.C., Lo, M.J., and Lin, H. (2009). The role of Cdk5 in retinoic acid-induced apoptosis of cervical cancer cell line. Chin. J. Physiol. 52, 23-30.
32. Levy, M. (1993). Propylthiouracil hepatotoxicity. A review and case presentation. Clin. Pediatr. (Phila.) 32, 25-29.
33. Lin, H., Chen, M.C., Chiu, C.Y., Song, Y.M., and Lin, S.Y. (2007). Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. J. Biol. Chem. 282, 2776-2784.
34. Lin, T., Hu, J., Wang, D., and Stocco, D.M. (1998). Interferon-gamma inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells. Endocrinology 139, 2217-2222.
35. Lo, M.J., Wang, S.W., Kau, M.M., Chen, J.J., Chen, Y.H., Fang, V.S., Ho, L.T., and Wang, P.S. (1998). Pharmacological effects of propylthiouracil on corticosterone secretion in male rats. J. Investig. Med. 46, 444-452.
36. Manna, P.R., Chandrala, S.P., Jo, Y., and Stocco, D.M. (2006). cAMPindependent signaling regulates steroidogenesis in mouse Leydig cells in the absence of StAR phosphorylation. J. Mol. Endocrinol. 37, 81-95.
37. Marchant, B., Brownlie, B.E., Hart, D.M., Horton, P.W., and Alexander, W.D. (1977). The placental transfer of propylthiouracil, methimazole and carbimazole. J. Clin. Endocrinol. Metab. 45, 1187-1193.
38. Melander, A., Wahlin, E., Danielson, K., and Hanson, A. (1977). Bioavailability of propylthiouracil: interindividual variation and influence of food intake. Acta Med. Scand. 201, 41-44.
39. Reinhart, A.J., Williams, S.C., Clark, B.J., and Stocco, D.M. (1999). SF-1 (steroidogenic factor-1) and C/EBP beta (CCAAT/enhancer binding proteinbeta) cooperate to regulate the murine StAR (steroidogenic acute regulatory) promoter. Mol. Endocrinol. 13, 729-741.
40. Rivkees, S.A. (2010). 63 years and 715 days to the "boxed warning": unmasking of the propylthiouracil problem. Int. J. Pediatr. Endocrinol. Advance Access published on July 12, 2010; doi: 10.1155/2010/658267.
41. Rivkees, S.A., and Mattison, D.R. (2009). Propylthiouracil (PTU) hepatoxicity in children and recommendations for discontinuation of use. Int. J. Pediatr. Endocrinol. 2009, 132041.
42. Rivkees, S.A., and Szarfman, A. (2010). Dissimilar hepatotoxicity profiles of propylthiouracil and methimazole in children. J. Clin. Endocrinol. Metab. 95, 3260-3267.
43. Sandhoff, T.W., Hales, D.B., Hales, K.H., and McLean, M.P. (1998). Transcriptional regulation of the rat steroidogenic acute regulatory protein gene by steroidogenic factor 1. Endocrinology 139, 4820-4831.
44. Sato, K., Mimura, H., Kato, S., Isozaki, O., Tsushima, T., and Shizume, K. (1983). Serum propylthiouracil concentration in patients with Graves' disease with various clinical course. Acta Endocrinol. (Copenh.) 104, 189-194.
45. Sorribes, M.M., Welinder, N.R., and Stangerup, S.E. (1999). Anti-neutrophil cytoplasmic antibody-associated mucocutaneous allergic vasculitis with oral manifestations caused by propylthiouracil. J. Laryngol. Otol. 113, 477-479.
46. Steel, R.D., and Torrie, J.H. (1960). In Principles and Procedures of Statistics. McGraw-Hill, New York, NY.
47. Streetman, D.D., and Khanderia, U. (2003). Diagnosis and treatment of Graves disease. Ann. Pharmacother. 37, 1100-1109.
48. Sugawara, T., Holt, J.A., Kiriakidou, M., and Strauss, J.F., III. (1996). Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene. Biochemistry 35, 9052-9059.
49. Sugawara, T., Kiriakidou, M., McAllister, J.M., Holt, J.A., Arakane, F., and Strauss, J.F., III. (1997). Regulation of expression of the steroidogenic acute regulatory protein (StAR) gene: a central role for steroidogenic factor 1. Steroids 62, 5-9.
50. Thrift, T.A., Bernal, A., Lewis, A.W., Neuendorff, D.A., Willard, C.C., and Randel, R.D. (1999). Effects of induced hypothyroidism on weight gains, lactation, and reproductive performance of primiparous Brahman cows. J. Anim. Sci. 77, 1844-1850.
51. Tsai, S.C., Lu, C.C., Chen, J.J., Chiao, Y.C., Wang, S.W., Hwang, J.J., and Wang, P.S. (1999). Inhibition of salmon calcitonin on secretion of progesterone and GnRH-stimulated pituitary luteinizing hormone. Am. J. Physiol. 277, E49-E55.
52. Wu, J.J., Wang, K.L., Wang, S.W., Hwang, G.S., Mao, I.F., Chen, M.L., and Wang, P.S. (2010). Differential effects of nonylphenol on testosterone secretion in rat Leydig cells. Toxicology 268, 1-7.
53. Yang, Y., and Gordon, C.J. (1997). Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil.Am. J. Physiol. 272, R1390-R1395.