Direct effects of propylthiouracil on testosterone production in monkeys

Chinese Journal of Physiology

Volumn 43, Issue 2, 2000, Pages 55-59

  Chiao, Yu Chung ^a   Chao, Hsu Li ^a   Huang, Seng Wong ^a   Wang, Paulus S ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

17 HSD; CAMP; Monkey; Propylthiouracil (PTU); Steroidogenesis; Testosterone (T)

Indexed keywords

ANDROSTENEDIONE; CHORIONIC GONADOTROPIN; CYCLIC AMP; FORSKOLIN; LUTEINIZING HORMONE; PROPYLTHIOURACIL; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; THYROXINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; ENDOCRINE FUNCTION; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MONKEY; NONHUMAN; STEROIDOGENESIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE; TESTOSTERONE SYNTHESIS; THYROXINE BLOOD LEVEL;

EID: 0033937056     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Ando, S., Panno, M.L., Beraldi, E., Tarandino, G., Salerno, M., Palmero, S., Prati, M. and Fugassa, E. Influence of hypothyroidism on in vitro testicular steroidogenesis in adult rats. Exp. Clin. Endocrinol. 96: 149-156, 1990.
2. Aruldhas, M.M., Valiyullah, H.M. and Govindarajulu, P. Specific effect of the thyroid on testicular enzymes involved in carbohydrate metabolism. I. Hypothyroidism. Intern. J. Androl. 5: 196-204, 1982.
3. 2u -globulin replacement therapy on testicular steroidogenic and gametogenic activities in rats. J. Endocrinol. 140: 343-347, 1994.
4. Chandrasekhar, Y., D'occhio, M.J., Holland, M.K. and Setchell, B. P. Activity of the hypothalamo-pituitary axis and testicular development in prepubertal ram lambs with induced hypothyroidism or hyperthyroidism. Endocrinology 117: 1645-1651, 1985.
5. Cooke, P.S., Hess, R.A., Porcelli, J. and Meisami, E. Increased sperm production in adult rats after transient neonatal hypothyroidism. Endocrinology 129: 244-248, 1991.
6. Cooke, P.S. and Meisami, E. Early postnatal hypothyroidism causes increased adult size of testis and other reproductive organs but does not increase testosterone levels. Endocrinology 129: 85-92, 1991.
7. Cooper, D.S. Antithyroid drugs. New Engl. J. Med. 311: 1353-1362, 1984.
8. Deidiker, R. and Demello, D.E. Propylthiouracil-induced fulminant hepatitis: case report and review of the literature. Pediatr. Pathol. Lab. Med. 16: 845-852, 1996.
9. Hall, P.H. Testicular steroid synthesis: Organization and regulation, in Knobil E, Neill J (eds): The Physiology of Reproduction, vol. 1. New York, NY, Raven, pp975-998, 1988.
10. Hardy, M.P., Kirby, J.D., Hess, R.A. and Cooke, P.S. Leydig cells increase their number but decline in steroidogenic function in the adult rat after neonatal hypothyroidism. Endocrinology 132: 2417-2420, 1993.
11. Jonas, M.M. and Eidson, M.S. Propylthiouracil hepatotoxicity: two pediatric cases and review of the literature. J. Pediatr. Gastroenterol. Nutr. 7: 776-779, 1988.
12. Khanum, A., Buczko, E. and Dufau, M.L. Essential role of adenosine triphosphate in activation of 17beta-hydroxysteroid dehydrogenase in the rat Leydig cell. Endocrinology 138: 1612-1620, 1997.
13. Kirby, J.D., Arambepola, N., Porkka-heiskanen, T., Kirby, Y.K., Rhoads, M.L., Nitta, H., Jetton, A.E., Iwamoto, G., Jackson, G.L., Turek, F.W. and Cooke, P.S. Neonatal hypothyroidism permanently alters follicle-stimulating hormone and luteinizing hormone production in the male rat. Endocrinology 138: 2713-2721, 1997.
14. Levy, M. Propylthiouracil hepatotoxicity. A review and case presentation. Clin. Pediatr. 32: 25-29, 1993.
15. scc activity in rat testicular interstitial cells. Br. J. Pharmacol. 125: 1635-1640, 1998.
16. Lo, M.J., Wang, S.W., Kau, M.M., Chen, J.J., Fang, V.S., Ho, L.T. and Wang, P.S. Pharmacological effects of propylthiouracil on corticosterone secretion in male rats. J. Invest. Med. 46: 444-452, 1998.
17. Steel, R.G.D. and Torrie, J.H. Principles and Procedures of Statistics. McGraw-Hill, New York, 1960.
18. Tsai, S.C., Chiao, Y.C., Lu, C.C., Doong, M.L., Chen, Y.H., Shin, H.C., Liaw, C., Wang, S.W. and Wang, P.S. Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes. Br. J. Pharmacol. 118: 984-988, 1996.
19. Yang, Y. and Gordon, C.J. Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil. Am. J. Physiol. 272: 1390-1395, 1997.