Efficacy of Rikkunshito, a traditional Japanese medicine (Kampo), in treating functional dyspepsia

Internal Medicine

Volumn 49, Issue 20, 2010, Pages 2195-2202

  Kusunoki, Hiroaki ^a   Haruma, Ken ^a   Hata, Jiro ^a   Ishii, Manabu ^a   Kamada, Tomoari ^a   Yamashita, Naohito ^a   Honda, Keisuke ^a   Inoue, Kazuhiko ^a   Imamura, Hiroshi ^a   Manabe, Noriaki ^a   Shiotani, Akiko ^a   Tsunoda, Tsukasa ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Gastric accommodation reflex; Gastroduodenal motility; Rikkunshito; Traditional japanese medicine (kampo); Ultrasound

Indexed keywords

DIGESTIVE TRACT AGENT; RIKKUNSHITO; TJ 43; UNCLASSIFIED DRUG;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DYSPEPSIA; FEMALE; HEARTBURN; HUMAN; JAPANESE; MALE; STOMACH EMPTYING; STOMACH MOTILITY; TRADITIONAL MEDICINE; TREATMENT RESPONSE;

ABDOMINAL PAIN; ADULT; AGED; CARDIA; DRUGS, CHINESE HERBAL; DYSPEPSIA; FEMALE; GASTRIC EMPTYING; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY; GASTROPARESIS; HUMANS; MALE; MEDICINE, KAMPO; MIDDLE AGED; ORGAN SIZE; PHYTOTHERAPY; POSTPRANDIAL PERIOD; REFLEX, ABNORMAL; SEVERITY OF ILLNESS INDEX; ULTRASONOGRAPHY, DOPPLER, COLOR;

EID: 78449280519     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.49.3803     Document Type: Article

References (43)

1. Tack J, Talley NJ, Camilleri M, et al. Functional gastrointestinal disorders. Gastroenterology 130: 1466-1479, 2006.
2. Karamanolis G, Caenepeel P, Arts J, Tack J. Association of predominant symptom with clinical characteristics and pathophysiological mechanisms in functional dyspepsia. Gastroenterology 130: 296-303, 2006.
3. Quartero AO, De Wit NJ, Lodder AC, Numans ME, Smout AJPM, Hoes AW. Disturbed solid-phase gastric emptying in functional dyspepsia. A meta-analysis. Dig Dis Sci 43: 2028-2033, 1998.
4. Van Den Elzen BDJ, Boeckxstaens GEE. A critical view on impaired accommodation as therapeutic target for functional dyspepsia. Aliment Pharmacol Ther 23: 1499-1510, 2006.
5. Kawahara H, Kubota A, Hasegawa T, et al. Effect of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux. Pediatr Surg Int 23: 1001-1005, 2007.
6. Kawahara H, Mitani Y, Nomura M, et al. Impact of rikkunshito, an herbal medicine, on delayed gastric emptying in profoundly handicapped patients. Pediatr Surg Int 25: 987-990, 2009.
7. Yagi M, Homma S, Kubota M, et al. The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectric activity in post-operative dyspeptic children after gastrointestinal surgery. Pediatr Surg Int 19: 760-765, 2004.
8. Tomono H, Ito Y, Watanabe T. Successful antiemetic treatment of TSUMURA Rikkunshi-to extract granules for ethical use in additional to other antiemetic agents in neoadjuvant chemotherapy for an advanced breast cancer patient. Gan To Kagaku Ryoho 33: 1129-1131, 2006.
9. Takahashi T, Endo S, Nakajima K, Souma Y, Nishida T. Effect of Rikkunshito, a Chinese herbal medicine, on stasis in patients after pylorus-preserving gastrectomy. World J Surg 33: 296-302, 2009.
10. Oka T, Tamagawa Y, Hayashida S, Kaneda Y, Kodama N, Tsuji S. Rikkunshito attenuates adverse gastrointestinal symptoms induced by fluvoxamine. Biopsychosoc Med 1: 21, 2007.
11. Tatsuta A, Ishii H. Effect of treatment with Lin-Jun-Zi-Tang (TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients. Aliment Pharmacol Ther 7: 459-462, 1993.
12. Terasawa K. Evidence-based reconstruction of Kampo medicine part-III-how should Kampo be evaluated? eCAM 1: 219-222, 2004.
13. Oyachi N, Takano K, Hasuda N, Arai H, Koshizuka K, Matsumoto M. Effect of Rikkunshi-to on infantile hypertrophic pyloric stenosis, refractory to atropine. Pediatr Int 50: 581-583, 2008.
14. Oikawa T, Ito G, Hoshino T, Koyama H, Hanawa T. Hangekobokuto (Banxia-houpo-tang), a Kampo medicine that treats functional dyspepsia. eCAM 6: 375-378, 2009.
15. Suzuki H, Inadomi JM, Hibi T. Japanese herbal medicine in functional gastrointestinal disorders. Neurogastroenterol Motil 21: 688-696,2009.
16. Hayakawa K, Arakawa T, Kase Y, et al. Liu-Jun-Zi-Tang, a Kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs. Drugs Exp Clin Rev 25: 211-218, 1999.
17. Fujimura J, Haruma K, Hata J, Yamanaka H, Sumii K, Kajiyama G. Quantitation of duodenogastric reflux and antral motility by color Doppler ultrasonography. Scand J Gastroenterol 29: 897-902,1994.
18. Okamoto E, Haruma K, Hata J, Tani H, Sumii K, Kajiyama G. Effects of octoreotide, a somatostatin analogue, on gastric function evaluated by real-time ultrasonography. Aliment Pharmacol Ther 11: 177-184, 1997.
19. Kusunoki H, Haruma K, Hata J, et al. Real-time ultrasonographic assessment of antroduodenal motility after ingestion of solid and liquid meals by patients with functional dyspepsia. J Gastroenterol Hepatol 15: 1022-1027, 2000.
20. Kusunoki H, Haruma K, Hata J, et al. Influence of Helicobacter pylori infection on gastrointestinal motility of dyspeptic patients -Real-time ultrasonographic study-. Gastroenterology 130 (Suppl 2): A433, 2006.
21. Hara M, Hata J, Haruma K, et al. Impaired fundic accommodation seen in functional dyspepsia. Gut 51 (Suppl III): A188, 2002.
22. Kusunoki H, Haruma K, Hata J, et al. Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers. A double-blind placebo-controlled ultrasonographic study. J Gastroenterol 2010 in press.
23. Hongo M, Fukuhara S, Green J. Shoukaki-ryoiki ni okeru QOL -nihongo ban GSRS niyoru QOL hyouka-. Shindan to Chiryo 87: 731-736, 1999 (in Japanese).
24. Matsumoto Y, Ito M, Tsuge M, et al. Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach. J Gastroenterol 44: 1118-1124, 2009. pitfalls of gastric barostat testing in dyspepsia. Neurogastroenterol
25. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 115: 1346-1352, 1998.
26. Bouras EP, Delgado-Aros S, Camilleri M, et al. SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication. Gut 51: 781-786, 2002.
27. Kim DY, Dolgado-Aros S, Camilleri M, et al. Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia. Am J Gastroenterol 96: 3099-3105, 2001.
28. Van Den, Elzen BDJ, Bennink RJ, Wieringa RE, Tytgat GNJ, Boeckxstaens GEE. Fundic accommodation assessed by SPECT scanning comparison with the gastric barostat. Gut 52: 1548-1554, 2003.
29. Jian R, Ducrot F, Ruskone A, et al. Symptomatic, radionuclide and therapeutic assessment of chronic idiopathic dyspepsia: A double-blind placebo-controlled evaluation of cisapride. Dig Dis Sci 34: 657-664, 1989.
30. Tack J, Broeckaert D, Coulie B, Janssens J. The influence of cisapride on gastric tone and the perception of gastric distension. Am J Physiol Gastrointest Liver Physiol 286: G278-G284, 2004.
31. Tack J, Vos R, Janssens J, Salter J, Jauffret S, Vandeplassche G. Influence of tegaserod on proximal gastric tone and on the perception of gastric distension. Aliment Pharmacol Ther 18: 1031-1037, 2003.
32. Caldarella MP, Azpiroz F, Malagerada JR. Antro-fundic dysfunctions in functional dyspepsia. Gastroenterology 124: 1220-1229, 2003.
33. Lee KJ, Vos R, Janssens J, Tack J. Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans. Am J Physiol Gastrointest Liver Physiol 286: G278-G284, 2004.
34. Tutuian R, Vos R, Karamanolis G, Tack J. An audit of technical pitfalls of gastric barostat testing in dyspepsia. Neurogastroenterol Motil 20: 113-118, 2008.
35. G-nitro-L-arginine. J Pharmacol Sci 98: 161-167, 2005.
36. Desai KM, Zembowicz A, Sessa WC, Vane JR. Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proc Natl Acad Sci USA 88: 11490-11494, 1991.
37. Galati MM, Monforte MT, Kirjavainen S, Forestieri AM, Trovato A. Biological effects of hesperidin, a citrus flavonoid (note 1): anti-inflammatory and analgesic activity. Farmaco 49: 709-712, 1994.
38. Sakata K, Hirose Y, Qiao Z, Tanaka T, Mori H. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett 199: 139-145, 2003.
39. Tominaga K, Kido T, Ochi M, et al. The traditional Japanese medicine rikkunshito promotes gastric emptying via the antagonistic action of the 5-HT3 receptor pathway in rat. eCAM: Oct 27: 1-8,2009 [Epub ahead of print].
40. Takeda H, Sadakane C, Hattori T, et al. Rikkunshito, an herbal medcine, suppresses cisplatin-indiced anorexia in rats via 5-HT2 receptor antagonism. Gastroenterology 134: 2004-2013, 2008.
41. Takeda H, Muto S, Hattori T, et al. Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibiton. Endocrinology 151: 244-252, 2010.
42. Matsumura T, Arai M, Yonemitsu Y, et al. The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in human and mice. J Gastroenterol 45: 300-307, 2010.
43. Yakabi K, Kurosawa S, Tamai M, et al. Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction. Regul Pept 161: 97-105, 2010.