Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach

Journal of Gastroenterology

Volumn 44, Issue 11, 2009, Pages 1118-1124

  Matsumoto, Yoshiaki ^a   Ito, Masanori ^a   Tsuge, Masataka ^a   Matsuo, Taiji ^a   Tanaka, Shinji ^b   Haruma, Ken ^c   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

^c KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Ecabet sodium; Functional dyspepsia; Gastric adaptive relaxation; Nitric oxide; Ultrasonography

Indexed keywords

12 SULFODEHYDROABIETIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; PLACEBO;

ADULT; ARTICLE; CELL STRAIN; DRUG TARGETING; ECHOGRAPHY; ENZYME ACTIVITY; GASTRIC ADAPTIVE RELAXATION; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE RELAXATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH DISTENSION; STOMACH MUSCLE; STOMACH PRESSURE; STOMACH VOLUME;

ADULT; ANTI-ULCER AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; DITERPENES, ABIETANE; DYSPEPSIA; GASTRIC DILATATION; GENE EXPRESSION REGULATION; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PRESSURE; STOMACH;

EID: 73449089725     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-009-0113-z     Document Type: Article

References (30)

1. B Geeraerts J Tack 2008 Functional dyspepsia: past, present, and future J Gastroenterol 43 251 255 10.1007/s00535-008-2167-8 18458839 (Pubitemid 351650034)
2. H Miwa T Osada A Nagahara T Ohkusa M Hojo T Tomita, et al. 2006 Effect of a gastro-protective agent, rebamipide, on symptom improvement in patients with functional dyspepsia: a double-blind placebo-controlled study in Japan J Gastroenterol Hepatol 21 1826 1831 10.1111/j.1440-1746.2006.04446.x 1:CAS:528:DC%2BD2sXkt1aqtg%3D%3D 17074021 (Pubitemid 44657004)
3. DA Peura J Gudmundson N Siepman BL Pilmer J Freston 2007 Proton pump inhibitors: effective first-line treatment for management of dyspepsia Dig Dis Sci 52 983 987 10.1007/s10620-006-9156-7 1:CAS:528:DC%2BD2sXjsVSjtr0%3D 17342402 (Pubitemid 46481236)
4. H Suzuki T Nishizawa T Hibi 2006 Therapeutic strategies for functional dyspepsia and the introduction of Rome III classification J Gastroenterol 41 513 523 10.1007/s00535-006-1847-5 16868798 (Pubitemid 44138192)
5. K Haruma H Kusunoki N Manabe T Kamada M Sato M Ishii, et al. 2008 Real-time assessment of gastroduodenal motility by ultrasonography Digestion 77 48 51 10.1159/000111488 18204262 (Pubitemid 351598548)
6. LE Troncon DG Thompson NK Ahluwalia J Barlow L Heggie 1995 Relations between upper abdominal symptoms and gastric distension abnormalities in dysmotility like functional dyspepsia and after vagotomy Gut 37 17 22 10.1136/gut.37.1.17 1:STN:280:DyaK2Mvgt1yjsw%3D%3D 7672673
7. T Hayakawa T Arakawa Y Kase S Akiyama A Ishige S Takeda, et al. 1999 Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs Drugs Exp Clin Res 25 211 218 1:CAS:528:DyaK1MXns1Gjsbg%3D 10568209
8. M Matsumoto R Yoshimura H Akiho N Higuchi K Kobayashi N Matsui, et al. 2007 Gastric emptying in diabetic patients by the (13)C-octanoic acid breath test: role of insulin in gastric motility J Gastroenterol 42 469 474 10.1007/s00535-007-2031-2 1:CAS:528:DC%2BD2sXntFKjsLc%3D 17671762 (Pubitemid 47050010)
9. H Kusunoki K Haruma J Hata H Tani E Okamoto K Sumii, et al. 2000 Real-time ultrasonographic assessment of antroduodenal motility after ingestion of solid and liquid meals by patients with functional dyspepsia J Gastroenterol Hepatol 15 1022 1027 10.1046/j.1440-1746.2000.02251.x 1:STN:280: DC%2BD3M3jt1aktg%3D%3D 11059931 (Pubitemid 30797707)
10. 13C-octanoic acid breath test in patients with functional dyspepsia: comparison with ultrasonography Scand J Gastroenterol 37 662 666 10.1080/00365520212508 1:STN:280:DC%2BD38zotVenuw%3D%3D 12126243 (Pubitemid 34620927)
11. Y Matsumoto M Ito D Kamino S Tanaka K Haruma K Chayama 2008 Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography J Gastroenterol 43 332 337 10.1007/s00535-008-2172-y 18592150 (Pubitemid 351958896)
12. D Kamino N Manabe J Hata K Haruma S Tanaka K Chayama 2008 Long-term ultrasonographic follow-up study of gastric motility in patients with functional dyspepsia J Clin Biochem Nutr 42 1 6 10.3164/jcbn.2008021 (Pubitemid 351912433)
13. H Murata S Kawano S Tsuji T Kamada Y Matsuzawa K Katsu, et al. 2003 Combination therapy of ecabet sodium and cimetidine compared with cimetidine alone for gastric ulcer: prospective randomized multicenter study J Gastroenterol Hepatol 18 1029 1033 10.1046/j.1440-1746.2003.03093.x 1:CAS:528:DC%2BD3sXotlSms7Y%3D 12911658 (Pubitemid 37175943)
14. M Iizuka H Itou S Konno T Shirasaka Y Horie K Shindo, et al. 2006 Efficacy of ecabet sodium enema on steroid resistant or steroid dependent ulcerative colitis Gut 55 1523 10.1136/gut.2006.099440 1:STN:280: DC%2BD28rktFSmsQ%3D%3D 16966708 (Pubitemid 44476802)
15. T Ohkusa I Takashimizu K Fujiki A Araki K Ariake K Shimoi, et al. 1998 Prospective evaluation of a new anti-ulcer agent, ecabet sodium, for the treatment of Helicobacter pylori infection Aliment Pharmacol Ther 12 457 461 10.1046/j.1365-2036.1998.00324.x 1:CAS:528:DyaK1cXjslGlu7g%3D 9663726 (Pubitemid 28247518)
16. H Kagaya M Kato Y Komatsu T Mizushima M Sukegawa K Nishikawa, et al. 2000 High-dose ecabet sodium improves the eradication rate of Helicobacter pylori in dual therapy with lansoprazole and amoxicillin Aliment Pharmacol Ther 14 1523 1527 10.1046/j.1365-2036.2000.00852.x 1:CAS:528:DC%2BD3cXovFGiurk%3D 11069325 (Pubitemid 30944734)
17. 2 in urea breath test J Gastroenterol 37 674 675 10.1007/s005350200108 1:CAS:528:DC%2BD38XnsFOjtLk%3D 12203087
18. JH Lee JJ Kim KB Hahm DH Lee N Kim SK Kim, et al. 2006 Efficacy and safety of ecabet sodium on functional dyspepsia: a prospective, double-blinded, randomized, multi-center controlled trial World J Gastroenterol 12 2756 2761 1:CAS:528:DC%2BD28Xls1WisLc%3D 16718764
19. T Suzuki M Hirano 2004 Clinical effect of ecabet sodium on functional dyspepsia J New Rem Clin 53 67 72 written in Japanese
20. MK Grant AE Cuadra EE El-Fakahany 2002 Endogenous expression of nNOS protein in several neuronal cell lines Life Sci 71 813 817 10.1016/S0024- 3205(02)01732-0 1:CAS:528:DC%2BD38XksFKnsL0%3D 12074940 (Pubitemid 34628823)
21. JS Finney N Kinnersley M Hughes CG O'Bryan-Tear J Lothian 1998 Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia J Clin Gastroenterol 26 312 320 10.1097/00004836-199806000-00022 1:STN:280:DyaK1czhtFemtg%3D%3D 9649020 (Pubitemid 28272513)
22. Y Nagao H Kodama T Yonezawa A Taguchi S Fujino K Nakahara, et al. 1998 Correlation between the drinkability of beer and gastric emptying Biosci Biotechnol Biochem 62 846 851 10.1271/bbb.62.846 1:CAS:528:DyaK1cXktV2itLw%3D 9648214
23. K Higuchi K Tominaga H Uno M Yasuda M Hashiume M Matsumoto, et al. 2002 Effects of ecabet sodium, an antiulcer drug, on gastric adaptive relaxation in isolated guinea-pig stomachs Drugs Exp Clin 28 105 111 1:CAS:528: DC%2BD3sXnsVSmtbs%3D
24. D Kobayashi H Mashimo N Watanabe 2004 nNOS-derived NO plays an important role in gastric adaptive relaxation Rinsho Byori 52 117 written in Japanese
25. KM Desai A Zembowicz WC Sessa JR Vane 1991 Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig Proc Natl Acad Sci USA 88 11490 11494 10.1073/pnas.88.24.11490 1:CAS:528: DyaK38Xls1enuw%3D%3D 1684865
26. T Inui N Saito K Okuyama M Kinoshita 2000 The effect of ecabet sodium on NO production by constitutive NO synthase in cultured gastric mucosal cells of guinea pigs Jpn J Pharmacol 82 252
27. H Yang Kim KB Hahm MG Choi JS Rew SY Seol HJ Chun, et al. 2007 Prospective multi-center trial for the efficacy of ecabet sodium on the relief of dyspepsia in Korean patients with chronic gastritis J Clin Biochem Nutr 41 160 168 10.3164/jcbn.2007022 18299710 (Pubitemid 350221822)
28. F Katagiri S Inoue Y Saito H Itoh M Takeyama 2005 Ecabet sodium raises plasma levels of calcitonin gene-related peptide and substance P in healthy humans J Pharm Pharmacol 57 799 805 10.1211/0022357056271 1:CAS:528: DC%2BD2MXlsV2lsrw%3D 15969937 (Pubitemid 40694890)
29. T Arakawa H Uno T Fukuda K Higuchi K Kobayashi T Kuroki 1997 New aspects of gastric adaptive relaxation, reflex after food intake for more food: involvement of capsaicin-sensitive sensory nerves and nitric oxide J Smooth Muscle Res 33 81 88 1:CAS:528:DyaK1cXktVSrtLw%3D 9533819
30. M Kinoshita E Kume H Tamaki 1995 Roles of prostaglandins, nitric oxide and the capsaicin-sensitive sensory nerves in gastroprotection produced by ecabet sodium J Pharmacol Exp Ther 275 494 501 1:CAS:528:DyaK2MXovVKmsL8%3D 7562591