Multiplex enzyme assays and inhibitor screening by mass spectrometry

Journal of Biomolecular Screening

Volumn 15, Issue 8, 2010, Pages 1001-1007

  Rathore, Rakesh ^a   Pribil, Patrick ^b   Corr, Jay J ^b   Seibel, William L ^a   Evdokimov, Artem ^c   Greis, Kenneth D ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b MDS Analytical Technologies   (Canada)

^c PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

acetylcholinesterase; mass spectrometry; multiplex enzyme assays; parallel analysis; protein kinase A

Indexed keywords

1,5 BIS(4 ALLYLDIMETHYLAMMONIUMPHENYL)PENTAN 3 ONE DIBROMIDE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ACETYLCHOLINESTERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; HUPERZINE A; STAUROSPORINE; TACRINE;

ARTICLE; DRUG ACTIVITY; DRUG TARGETING; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME MECHANISM; HIGH THROUGHPUT SCREENING; IC 50; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; CALIBRATION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ASSAYS; ENZYME INHIBITORS; GPI-LINKED PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; MODELS, BIOLOGICAL; SMALL MOLECULE LIBRARIES;

EID: 78449276240     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110363824     Document Type: Article

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