Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum

Journal of Natural Medicines

Volumn 63, Issue 3, 2009, Pages 304-310

  Zhang, Qun ^a   Zuo, Feng ^a   Nakamura, Norio ^a   Ma, Chao Mei ^a   Hattori, Masao ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Ganoderiol F; Ganoderma lucidum; LC MS MS; Metabolism; Pharmacokinetics

Indexed keywords

GANODERIC ACID A; GANODERIOL F; GANODERMA LUCIDUM EXTRACT; GANODERMATRIOL; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; FECES; FEMALE; GANODERMA LUCIDUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE FLORA; LD 50; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SOLID PHASE EXTRACTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BACTERIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPTANOIC ACIDS; HUMANS; INTESTINES; LANOSTEROL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; REISHI; TANDEM MASS SPECTROMETRY; TRITERPENES;

EID: 67650732691     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-009-0337-5     Document Type: Article

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