Sex differences in leg vasodilation during graded knee extensor exercise in young adults

Journal of Applied Physiology

Volumn 103, Issue 5, 2007, Pages 1583-1591

  Parker, Beth A ^a   Smithmyer, Sandra L ^a   Pelberg, Justin A ^a   Mishkin, Aaron D ^a   Herr, Michael D ^b   Proctor, David N ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Femoral artery dilation; Muscle blood flow

Indexed keywords

ADULT; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; EXERCISE TEST; EXTENSOR MUSCLE; FEMALE; FEMORAL ARTERY FLOW; FITNESS; HEART RATE; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; LEG BLOOD FLOW; LIMB MOVEMENT; MALE; MUSCLE BLOOD FLOW; MUSCLE EXCITATION; MUSCLE EXERCISE; MUSCLE FIBER MEMBRANE CONDUCTANCE; NORMAL HUMAN; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; SEX DIFFERENCE; VASODILATATION;

ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; ELECTROMYOGRAPHY; EXERCISE; FEMALE; FEMORAL ARTERY; HEART RATE; HUMANS; KNEE; LEG; MALE; MUSCLE CONTRACTION; QUADRICEPS MUSCLE; REGIONAL BLOOD FLOW; SEX FACTORS; ULTRASONOGRAPHY, DOPPLER, DUPLEX; VASODILATION;

EID: 35649020184     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00662.2007     Document Type: Article

References (55)

1. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
2. Andersen P, Adams RP, Sjogaard G, Thorboe A, Saltin B. Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 59: 1647-1653, 1985.
3. Andersen P, Saltin B. Maximal perfusion of skeletal muscle in man. J Physiol 366: 233-249, 1985.
4. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 36: 936-942, 1982.
5. Bailey DM, Lawrenson L, McEneny J, Young IS, James PE, Jackson SK, Henry RR, Mathieu-Costello O, McCord JM, Richardson RS. Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle. Free Radic Res 41: 182-190, 2007.
6. Barbacanne MA, Rami J, Michel JB, Souchard JP, Philippe M, Besombes JP, Bayard F, Arnal JF. Estradiol increases rat aorta endothelium-derived relaxing factor (EDRF) activity without changes in endothelial NO synthase gene expression: possible role of decreased endothelium-derived superoxide anion production. Cardiovasc Res 41: 672-681, 1999.
7. Brandes RP, Mugge A. Gender differences in the generation of superoxide anions in the rat aorta. Life Sci 60: 391-396, 1997.
8. Christou DD, Jones PP, Jordan J, Diedrich A, Robertson D, Seals DR. Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation 111: 494-498, 2005.
9. Clark BC, Collier SR, Manini TM, Ploutz-Snyder LL. Sex differences in muscle fatigability and activation patterns of the human quadriceps femoris Eur J Appl Physiol 94: 196-206, 2005.
10. 2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol 26: 707-715, 1999.
11. David FL, Carvalho MH, Cobra AL, Nigro D, Fortes ZB, Reboucas NA, Tostes RC. Ovarian hormones modulate endothelin-1 vascular reactivity and mRNA expression in DOCA-salt hypertensive rats. Hypertension 38: 692-696, 2001.
12. Dietz NM. Gender and nitric oxide-mediated vasodilation in humans. Lupus 8: 402-408, 1999.
13. Ettinger SM, Silber DH, Gray KS, Smith MB, Yang QX, Kunselman AR, Sinoway LI. Effects of the ovarian cycle on sympathetic neural outflow during static exercise. J Appl Physiol 85: 2075-2081, 1998.
14. Fleg JL, O'Connor F, Gerstenblith G, Becker LC, Clulow J, Schulman SP, Lakatta EG. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol 78: 890-900, 1995.
15. Gonzalez-Alonso J, Mortensen SP, Dawson EA, Secher NH, Damsgaard R. Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin. J Physiol 572: 295-305, 2006.
16. Hagberg JM, Seals DR, Yerg JE, Gavin J, Gingerich R, Premachandra B, Holloszy JO. Metabolic responses to exercise in young and older athletes and sedentary men. J Appl Physiol 65: 900-908, 1988.
17. Hargreaves M, McKenna MJ, Jenkins DG, Warmington SA, Li JL, Snow RJ, Febbraio MA. Muscle metabolites and performance during high-intensity, intermittent exercise. J Appl Physiol 84: 1687-1691, 1998.
18. Hicks AL, Kent-Braun J, Ditor DS. Sex differences in human skeletal muscle fatigue. Exerc Sport Sci Rev 29: 109-112, 2001.
19. Hogarth AJ, Mackintosh AF, Mary DA. Gender-related differences in the sympathetic vasoconstrictor drive of normal subjects. Clin Sci (Lond) 112: 353-361, 2007.
20. Hughson RL, MacDonald MJ, Shoemaker JK, Borkhoff C. Alveolar oxygen uptake and blood flow dynamics in knee extension ergometry. Methods Inf Med 36: 364-367, 1997.
21. Hunter SK, Enoka RM. Sex differences in the fatigability of arm muscles depends on absolute force during isometric contractions. J Appl Physiol 91: 2686-2694, 2001.
22. Jasperse JL, Laughlin MH. Flow-induced dilation of rat soleus feed arteries. Am J Physiol Heart Circ Physiol 273: H2423-H2427, 1997.
23. Jones PR, Pearson J. Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults. J Physiol 204: 63P-66P, 1969.
24. Kahonen M, Tolvanen JP, Sallinen K, Wu X, Porsti I. Influence of gender on control of arterial tone in experimental hypertension. Am J Physiol Heart Circ Physiol 275: H15-H22, 1998.
25. Kent-Braun JA, Ng AV, Doyle JW, Towse TF. Human skeletal muscle responses vary with age and gender during fatigue due to incremental isometric exercise. J Appl Physiol 93: 1813-1823, 2002.
26. Kimmerly DS, Wong S, Menon R, Shoemaker JK. Forebrain neural patterns associated with sex differences in autonomic and cardiovascular function during baroreceptor unloading. Am J Physiol Regul Integr Comp Physiol 292: R715-R722, 2007.
27. Kneale BJ, Chowienczyk PJ, Brett SE, Coltart DJ, Ritter JM. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol 36: 1233-1238, 2000.
28. Koch DW, Newcomer SC, Proctor DN. Blood flow to exercising limbs varies with age, gender, and training status. Can J Appl Physiol 30: 554-575, 2005.
29. Koskolou MD, Calbet JA, Radegran G, Roach RC. Hypoxia and the cardiovascular response to dynamic knee-extensor exercise. Am J Physiol Heart Circ Physiol 272: H2655-H2663, 1997.
30. Krustrup P, Hellsten Y, Bangsbo J. Intense interval training enhances human skeletal muscle oxygen uptake in the initial phase of dynamic exercise at high but not at low intensities. J Physiol 559: 335-345, 2004.
31. Lawrenson L, Poole JG, Kim J, Brown C, Patel P, Richardson RS. Vascular and metabolic response to isolated small muscle mass exercise: effect of age. Am J Physiol Heart Circ Physiol 2 85: H1023-H1031, 2003.
32. Leuenberger U, Sinoway L, Gubin S, Gaul L, Davis D, Zelis R. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol 75: 668-674, 1993.
33. Levenson J, Pessana F, Gariepy J, Armentano R, Simon A. Gender differences in wall shear-mediated brachial artery vasoconstriction and vasodilation. J Am Coll Cardiol 38: 1668-1674, 2001.
34. Littell R, Milliken G, Stroup W, Wolfinger R, Schabenberber O. SAS for Mixed Models. Cary, NC: SAS Institute, 2006.
35. Lutjemeier BJ, Miura A, Scheuermann BW, Koga S, Townsend DK, Barstow TJ. Muscle contraction-blood flow interactions during upright knee extension exercise in humans. J Appl Physiol 98: 1575-1583, 2005.
36. MacDonald MJ, Shoemaker JK, Tschakovsky ME, Hughson RL. Alveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans. J Appl Physiol 85: 1622-1628, 1998.
37. 1-adrenergic responses in rat mesenteric arteries. Am J Physiol Heart Circ Physiol 284: H1737-H1743, 2003.
38. Mendelsohn ME. Genomic and nongenomic effects of estrogen in the vasculature. Am J Cardiol 90: 3F-6F, 2002.
39. Pincivero DM, Coelho AJ, Campy RM. Perceived exertion and maximal quadriceps femoris muscle strength during dynamic knee extension exercise in young adult males and females. Eur J Appl Physiol 89: 150-156, 2003.
40. Proctor DN, Le KU, Ridout SJ. Age and regional specificity of peak limb vascular conductance in men. J Appl Physiol 98: 193-202, 2005.
41. Radegran G. Ultrasound Doppler estimates of femoral artery blood flow during dynamic knee extensor exercise in humans. J Appl Physiol 83: 1383-1388, 1997.
42. Radegran G, Blomstrand E, Saltin B. Peak muscle perfusion and oxygen uptake in humans: importance of precise estimates of muscle mass. J Appl Physiol 87: 2375-2380, 1999.
43. Radegran G, Saltin B. Human femoral artery diameter in relation to knee extensor muscle mass, peak blood flow, and oxygen uptake. Am J Physiol Heart Circ Physiol 278: H162-H167, 2000.
44. Ray CA, Rea RF, Clary MP, Mark AL. Muscle sympathetic nerve responses to dynamic one-legged exercise: effect of body posture. Am J Physiol Heart Circ Physiol 264: H1-H7, 1993.
45. 2 extraction compromised? J Appl Physiol 75: 1911-1916, 1993.
46. Ridout SJ, Parker BA, Proctor DN. Age and regional specificity of peak limb vascular conductance in women. J Appl Physiol 99: 2067-2074, 2005.
47. 2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans. Am J Physiol Heart Circ Physiol 276: H438-H445, 1999.
48. Rogers J, Sheriff DD. Role of estrogen in nitric oxide- and prostaglandin-dependent modulation of vascular conductance during treadmill locomotion in rats. J Appl Physiol 97: 756-763, 2004.
49. Russ DW, Kent-Braun JA. Sex differences in human skeletal muscle fatigue are eliminated under ischemic conditions. J Appl Physiol 94: 2414-2422, 2003.
50. Saltin B, Radegran G, Koskolou MD, Roach RC. Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol Scand 162: 421-436, 1998.
51. Sarabi M, Millgard J, Lind L. Effects of age, gender and metabolic factors on endothelium-dependent vasodilation: a population-based study. J Intern Med 246: 265-274, 1999.
52. Simoneau JA, Lortie G, Boulay MR, Thibault MC, Theriault G, Bouchard C. Skeletal muscle histochemical and biochemical characteristics in sedentary male and female subjects. Can J Physiol Pharmacol 63: 30-35, 1985.
53. Sudhir K, Chou TM, Mullen WL, Hausmann D, Collins P, Yock PG, Chatterjee K. Mechanisms of estrogen-induced vasodilation: in vivo studies in canine coronary conductance and resistance arteries. J Am Coll Cardiol 26: 807-814, 1995.
54. Walther G, Nottin S, Dauzat M, Obert P. Femoral and axillary ultrasound blood flow during exercise: a methodological study. Med Sci Sports Exerc 38: 1353-1361, 2006.
55. Wray DW, Donato AJ, Uberoi A, Merlone JP, Richardson RS. Onset exercise hyperaemia in humans: partitioning the contributors. J Physiol 565: 1053-1060, 2005.