Conformational analysis and automated receptor docking of selective arylacetamide-based κ-opioid agonists

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4777-4789

  Subramanian, Govindan ^a   Germana Paterlini, M ^a   Larson, Dennis L ^a   Portoghese, Philip S ^a   Ferguson, David M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N [1 ISOPROPYL 2 (1 PYRROLIDINYL)ETHYL] N METHYLBENZENEACETAMIDE; 3,4 DICHLORO N METHYL N [1 PHENYL 2 (1 PYRROLIDINYL)ETHYL]BENZENEACETAMIDE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ACETAMIDE DERIVATIVE; BRL 52537; BRL 52656; ENADOLINE; KAPPA OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; SPIRADOLINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; RECEPTOR BINDING; STRUCTURE ANALYSIS;

ACETAMIDES; BINDING SITES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, OPIOID, KAPPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7844249248     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9803166     Document Type: Article

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