Flowsheet simulation of aqueous two-phase extraction systems for protein purification

Journal of Chemical Technology and Biotechnology

Volumn 85, Issue 12, 2010, Pages 1575-1587

  Ahmad, Murni M ^a   Hauan, Steinar ^b   Przybycien, Todd M ^b  

^a DEPARTMENT OF CHEMICAL ENGINEERING   (Malaysia)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Aqueous two phase phase equilibria; Bioprocess design; Bioseparations; Protein partitioning

Indexed keywords

AQUEOUS TWO-PHASE EXTRACTION; AQUEOUS TWO-PHASE PHASE EQUILIBRIA; BIO SEPARATION; BIOPROCESS DESIGN; DESIGN APPROACHES; DESIGN SPACES; FEASIBLE SOLUTION; FLORY-HUGGINS THEORY; FLOW SHEET SIMULATION; FLOWSHEET; GIBBS ENERGY; INDUSTRIAL SCALE; INTEGRATED FASHION; LIQUID-LIQUID EXTRACTION; MASS-FLOW RATE; PEG6000; PHASE FORMATIONS; PHOSPHOFRUCTOKINASE; PROCESS COSTS; PRODUCT PURITY; PRODUCT YIELDS; PROTEIN PARTITIONING; PROTEIN PURIFICATION; PROTEIN SEPARATIONS; SETTLING RATE; TARGET PROTEINS; TWO PHASE SYSTEMS;

DESIGN; ETHYLENE; ETHYLENE GLYCOL; FLOWCHARTING; GLUCOSE; KNOWLEDGE BASED SYSTEMS; LIQUIDS; METAL RECOVERY; OPTIMIZATION; PHASE SEPARATION; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; PROTEINS; PURIFICATION; SOLVENT EXTRACTION; THERMODYNAMICS;

PHASE EQUILIBRIA;

6 PHOSPHOFRUCTOKINASE; POLYETHYLENE DERIVATIVE; POLYETHYLENE GLYCOL DEXTRAN; POLYETHYLENE GLYCOL SALT; UNCLASSIFIED DRUG;

AQUEOUS TWO PHASE EXTRACTION SYSTEM; ARTICLE; EXTRACTION; FLOWSHEET SIMULATION; PROTEIN PURIFICATION; SIMULATION;

EID: 78349271218     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.2469     Document Type: Article

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