Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors

ChemMedChem

Volumn 5, Issue 11, 2010, Pages 1850-1854

  Ghosh, Arun K ^a   Xu, Chun Xiao ^a   Rao, Kalapala Venkateswara ^a   Baldridge, Abigail ^a   Agniswamy, Johnson ^b   Wang, Yuan Fang ^b   Weber, Irene T ^b   Aoki, Manabu ^c   Miguel, Salcedo Gomez Pedro ^c   Amano, Masayuki ^c   Mitsuya, Hiroaki ^c,d  

^a PURDUE UNIVERSITY   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

dimerization inhibitors; HIV 1 protease; multidrug resistance; oxatricyclic ligands; X ray crystallography

Indexed keywords

AMPRENAVIR; DARUNAVIR; GRL 0519A; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; LIGAND BINDING; MULTIDRUG RESISTANCE; NONHUMAN; OZONOLYSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SYNTHESIS; STEREOCHEMISTRY;

CARBAMATES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, VIRAL; HETEROCYCLIC COMPOUNDS, 3-RING; HIV INFECTIONS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; LIGANDS; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 78349254240     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000318     Document Type: Article

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