Endotoxin deactivation by transient acidification

Cell Transplantation

Volumn 19, Issue 8, 2010, Pages 1047-1054

  Ribeiro, Melina M ^a,b   Xu, Xiumin ^a   Klein, Dagmar ^a   Kenyon, Norma S ^a   Ricordi, Camillo ^a   Felipe, Maria Sueli S ^b   Pastori, Ricardo L ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b INSTITUTO DE CIÊNCIAS BIOLÓGICAS   (Brazil)

Author keywords

Endotoxin; Lypopolysaccharide; Pyrogen; Recombinant protein

Indexed keywords

ENDOTOXIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5C8; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; UREA;

ACIDIFICATION; ANIMAL CELL; ARTICLE; EXPERIMENTAL RABBIT; HYBRIDOMA; IN VITRO STUDY; IN VIVO STUDY; ISOELECTRIC POINT; LYMPHOCYTE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION;

ANTIBODIES, MONOCLONAL; ENDOTOXINS; HYDROGEN-ION CONCENTRATION; RECOMBINANT PROTEINS; UREA;

BACTERIA (MICROORGANISMS); LIMULUS;

EID: 78349233862     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X500643     Document Type: Article

References (52)

1. Aida, Y.; Pabst, M. J. Removal of endotoxin from protein solutions by phase separation using Triton X-114. J. Immunol. Methods 132(2):191-195; 1990.
2. Anspach, F. B.; Hilbeck, O. Removal of endotoxins by affinity sorbents. J. Chromatogr. A 711(1):81-92; 1995.
3. Arakawa, M.; Yasutake, M.; Miyamoto, M.; Takano, T.; Asoh, S.; Ohta, S. Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion. Life Sci. 80(22):2076-2084; 2007.
4. Bosnali, M.; Edenhofer, F. Generation of transducible versions of transcription factors Oct4 and Sox2. Biol. Chem. 389(7):851-861; 2008.
5. Caron, N. J.; Torrente, Y.; Camirand, G.; Bujold, M.; Chapdelaine, P.; Leriche, K.; Bresolin, N.; Tremblay, J. P. Intracellular delivery of a Tat-eGFP fusion protein into muscle cells. Mol. Ther. 3(3):310-318; 2001.
6. Chen, R. H.; Huang, C. J.; Newton, B. S.; Ritter, G.; Old, L. J.; Batt, C. A. Factors affecting endotoxin removal from recombinant therapeutic proteins by anion exchange chromatography. Protein Expr. Purif. 64(1):76-81; 2009.
7. Coughlin, R. T.; Peterson, A. A.; Haug, A.; Pownall, H. J.; McGroarty, E. J. A pH titration study on the ionic bridging within lipopolysaccharide aggregates. Biochim. Biophys. Acta 821(3):404-412; 1985.
8. Derer, W.; Easwaran, H. P.; Knopf, C. W.; Leonhardt, H.; Cardoso, M. C. Direct protein transfer to terminally differentiated muscle cells. J. Mol. Med. 77(8):609-613; 1999.
9. Ding, J. L.; Zhu, Y.; Ho, B. High-performance affinity capture-removal of bacterial pyrogen from solutions. J. Chromatogr. B Biomed. Sci. Appl. 759(2):237-246; 2001.
10. Dominguez-Bendala, J.; Klein, D.; Ribeiro, M.; Ricordi, C.; Inverardi, L.; Pastori, R.; Edlund, H. TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro. Diabetes 54(3):720-726; 2005.
11. Dudley, A.; McKinstry, W.; Thomas, D.; Best, J.; Jenkins, A. Removal of endotoxin by reverse phase HPLC abolishes anti-endothelial cell activity of bacterially expressed plasminogen kringle 5. Biotechniques 35(4):724-726, 728, 730; 2003.
12. Duvic, B.; Brehelin, M. Two major proteins from locust plasma are involved in coagulation and are specifically precipitated by laminarin, a beta-1,3-glucan. Insect Biochem. Mol. Biol. 28(12):959-967; 1998.
13. Eum, W. S.; Kim, D. W.; Hwang, I. K.; Yoo, K. Y.; Kang, T. C.; Jang, S. H.; Choi, H. S.; Choi, S. H.; Kim, Y. H.; Kim, S. Y.; Kwon, H. Y.; Kang, J. H.; Kwon, O. S.; Cho, S. W.; Lee, K. S.; Park, J.; Won, M. H.; Choi, S. Y. In vivo protein transduction: Biologically active intact pep-1-superoxide dismutase fusion protein efficiently protects against ischemic insult. Free Radic. Biol. Med. 37(10):1656-1669; 2004.
14. Gerba, C. P.; Hou, K. Endotoxin removal by charge-modified filters. Appl. Environ. Microbiol. 50(6):1375-1377; 1985.
15. Gustafsson, A. B.; Gottlieb, R. A.; Granville, D. J. TAT-mediated protein transduction: Delivering biologically active proteins to the heart. Methods Mol. Med. 112:81-90; 2005.
16. Hanora, A.; Plieva, F. M.; Hedstrom, M.; Galaev, I. Y.; Mattiasson, B. Capture of bacterial endotoxins using a supermacroporous monolithic matrix with immobilized polyethyleneimine, lysozyme or polymyxin B. J. Biotechnol. 118(4):421-433; 2005.
17. Haupt, S.; Edenhofer, F.; Peitz, M.; Leinhaas, A.; Brustle, O. Stage-specific conditional mutagenesis in mouse embryonic stem cell-derived neural cells and postmitotic neurons by direct delivery of biologically active Cre recombinase. Stem Cells 25(1):181-188; 2007.
18. Hou, K. C.; Zaniewski, R. Depyrogenation by endotoxin removal with positively charged depth filter cartridge. J. Parenter. Sci. Technol. 44(4):204-209; 1990.
19. Katsura, K.; Takahashi, K.; Asoh, S.; Watanabe, M.; Sakurazawa, M.; Ohsawa, I.; Mori, T.; Igarashi, H.; Ohkubo, S.; Katayama, Y.; Ohta, S. Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. J. Neurochem. 106(1):258-270; 2008.
20. Kenyon, N. S.; Chatzipetrou, M.; Masetti, M.; Ranuncoli, A.; Oliveira, M.; Wagner, J. L.; Kirk, A. D.; Harlan, D. M.; Burkly, L. C.; Ricordi, C. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc. Natl. Acad. Sci. USA 96(14):8132-8137; 1999.
21. Koya, V.; Lu, S.; Sun, Y. P.; Purich, D. L.; Atkinson, M. A.; Li, S. W.; Yang, L. J. Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox- 1: A novel protein transduction domain-based therapy. Diabetes 57(3):757-769; 2008.
22. Kubo, E.; Fatma, N.; Akagi, Y.; Beier, D. R.; Singh, S. P.; Singh, D. P. TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am. J. Physiol. Cell. Physiol. 294(3):C842-855; 2008.
23. Liu, S.; Tobias, R.; McClure, S.; Styba, G.; Shi, Q.; Jackowski, G. Removal of endotoxin from recombinant protein preparations. Clin. Biochem. 30(6):455-463; 1997.
24. Lu, S. J.; Feng, Q.; Ivanova, Y.; Luo, C.; Li, T.; Li, F.; Honig, G. R.; Lanza, R. Recombinant HoxB4 fusion proteins enhance hematopoietic differentiation of human embryonic stem cells. Stem Cells Dev. 16(4):547-559; 2007.
25. Magalhaes, P. O.; Lopes, A. M.; Mazzola, P. G.; Rangel-Yagui, C.; Penna, T. C.; Pessoa, Jr., A. Methods of endotoxin removal from biological preparations: A review. J. Pharm. Pharm. Sci. 10(3):388-404; 2007.
26. Martich, G. D.; Boujoukos, A. J.; Suffredini, A. F. Response of man to endotoxin. Immunobiology 187(3-5): 403-416; 1993.
27. Mendoza, V.; Klein, D.; Ichii, H.; Ribeiro, M. M.; Ricordi, C.; Hankeln, T.; Burmester, T.; Pastori, R. L. Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction. Transplant. Proc. 37(1):237-240; 2005.
28. Mueller, M.; Lindner, B.; Kusumoto, S.; Fukase, K.; Schromm, A. B.; Seydel, U. Aggregates are the biologically active units of endotoxin. J. Biol. Chem. 279(25): 26307-26313; 2004.
29. Nagel, F.; Falkenburger, B. H.; Tonges, L.; Kowsky, S.; Poppelmeyer, C.; Schulz, J. B.; Bahr, M.; Dietz, G. P. Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease. J. Neurochem. 105(3):853-864; 2008.
30. Neidhardt, E. A.; Luther, M. A.; Recny, M. A. Rapid, two-step purification process for the preparation of pyrogen-free murine immunoglobulin G1 monoclonal antibodies. J. Chromatogr. 590(2):255-261; 1992.
31. Noguchi, H.; Bonner-Weir, S.; Wei, F. Y.; Matsushita, M.; Matsumoto, S. BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes 54(10):2859-2866; 2005.
32. Ohta, Y.; Kamiya, T.; Nagai, M.; Nagata, T.; Morimoto, N.; Miyazaki, K.; Murakami, T.; Kurata, T.; Takehisa, Y.; Ikeda, Y.; Asoh, S.; Ohta, S.; Abe, K. Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. Res. 86(13):3028-3037; 2008.
33. Pastori, R. L.; Klein, D.; Ribeiro, M. M.; Ricordi, C. Delivery of proteins and peptides into live cells by means of protein transduction domains: Potential application to organ and cell transplantation. Transplantation 77(11): 1627-1631; 2004.
34. Petsch, D.; Anspach, F. B. Endotoxin removal from protein solutions. J. Biotechnol. 76(2-3):97-119; 2000.
35. Pileggi, A.; Fenjves, E. S.; Klein, D.; Ricordi, C.; Pastori, R. L. Protecting pancreatic beta-cells. IUBMB Life 56(7):387-394; 2004.
36. Qu, H. Y.; Zhang, T.; Li, X. L.; Zhou, J. P.; Zhao, B. Q.; Li, Q.; Sun, M. J. Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice. Eur. J. Pharmacol. 594(1-3):93-100; 2008.
37. Reichelt, P.; Schwarz, C.; Donzeau, M. Single step protocol to purify recombinant proteins with low endotoxin contents. Protein Expr. Purif. 46(2):483-488; 2006.
38. Ribeiro, M. M.; Klein, D.; Pileggi, A.; Molano, R. D.; Fraker, C.; Ricordi, C.; Inverardi, L.; Pastori, R. L. Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells. Biochem. Biophys. Res. Commun. 305(4):876-881; 2003.
39. Ritzen, U.; Rotticci-Mulder, J.; Stromberg, P.; Schmidt, S. R. Endotoxin reduction in monoclonal antibody preparations using arginine. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 856(1-2):343-347; 2007.
40. Scherfer, C.; Karlsson, C.; Loseva, O.; Bidla, G.; Goto, A.; Havemann, J.; Dushay, M. S.; Theopold, U. Isolation and characterization of hemolymph clotting factors in Drosophila melanogaster by a pullout method. Curr. Biol. 14(7):625-629; 2004.
41. Schwarze, S. R.; Dowdy, S. F. In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol. Sci. 21(2):45-48; 2000.
42. Sharma, S. K. Endotoxin detection and elimination in biotechnology. Biotechnol. Appl. Biochem. 8(1):5-22; 1986.
43. Snyder, E. L.; Dowdy, S. F. Cell penetrating peptides in drug delivery. Pharm. Res. 21(3):389-393; 2004.
44. Spitere, K.; Toulouse, A.; O'Sullivan, D. B.; Sullivan, A. M. TAT-PAX6 protein transduction in neural progenitor cells: A novel approach for generation of dopaminergic neurones in vitro. Brain Res. 1208:25-34; 2008.
45. Theopold, U.; Schmidt, O.; Soderhall, K.; Dushay, M. S. Coagulation in arthropods: Defence, wound closure and healing. Trends Immunol. 25(6):289-294; 2004.
46. Ueda, M.; Matsumoto, S.; Hayashi, S.; Kobayashi, N.; Noguchi, H. Cell surface heparan sulfate proteoglycans mediate the internalization of PDX-1 protein. Cell Transplant. 17(1-2):91-97; 2008.
47. Vaara, M.; Nurminen, M. Outer membrane permeability barrier in Escherichia coli mutants that are defective in the late acyltransferases of lipid A biosynthesis. Antimicrob. Agents Chemother. 43(6):1459-1462; 1999.
48. Wang, Q.; Zhang, J. P.; Smith, T. R.; Hurst, W. E.; Sulpizio, T. An electrokinetic study on a synthetic adsorbent of crystalline calcium silicate hydrate and its mechanism of endotoxin removal. Colloids Surf. B. Biointerfaces 44(2-3):110-116; 2005.
49. Weisbart, R. H.; Hansen, J. E.; Nishimura, R. N.; Chan, G.; Wakelin, R.; Chang, S. S.; Baresi, L.; Chamberlain, J. S. An intracellular delivery vehicle for protein transduction of micro-dystrophin. J. Drug Target. 13(2):81-87; 2005.
50. Xiong, F.; Xiao, S.; Yu, M.; Li, W.; Zheng, H.; Shang, Y.; Peng, F.; Zhao, C.; Zhou, W.; Chen, H.; Fang, L.; Chamberlain, J. S.; Zhang, C. Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport. BMC Neurosci. 8:50; 2007.
51. Yun, C. O.; Shin, H. C.; Kim, T. D.; Yoon, W. H.; Kang, Y. A.; Kwon, H. S.; Kim, S. K.; Kim, J. S. Transduction of artificial transcriptional regulatory proteins into human cells. Nucleic Acids Res. 36(16):e103; 2008.
52. Zhou, H.; Wu, S.; Joo, J. Y.; Zhu, S.; Han, D. W.; Lin, T.; Trauger, S.; Bien, G.; Yao, S.; Zhu, Y.; Siuzdak, G.; Schöler, H. R.; Duan, L.; Ding, S. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4(5):381-384; 2009.