Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2852-2858

  Zhang, Han Zhong ^a   Crogan Grundy, Candace ^a   May, Chris ^a   Drewe, John ^a   Tseng, Ben ^a   Cai, Sui Xiong ^a  

^a EpiCept Corporation   (United States)

Author keywords

Anticancer agents; Apoptosis inducers; Cell growth inhibition; HTS; In vivo activity; Tubulin inhibitors

Indexed keywords

1 [2 (2,5 DIMETHOXYPHENYLTHIO)BENZYL]SEMICARBAZIDE; 1 [2 (2,5 DIMETHOXYPHENYLTHIO)BENZYLIDENE]SEMICARBAZIDE; 2 (2,5 DIMETHOXYPHENOXY)BENZALDEHYDE; 2 (2,5 DIMETHOXYPHENYLSULFINYL)BENZALDEHYDE; 2 (3,5 DIMETHOXYPHENOXY)BENZALDEHYDE; [2 (2,5 DIMETHOXYPHENOXY)BENZYLIDENEAMINO]GUANIDINE; [2 (2,5 DIMETHOXYPHENYLSULFINYL)BENZYLIDENEAMINO]GUANIDINE; [2 (2,5 DIMETHOXYPHENYLTHIO) 3 METHOXYBENZYLIDENEAMINO]GUANIDINE; [2 (2,5 DIMETHOXYPHENYLTHIO) 4 METHOXYBENZYLIDENEAMINO]GUANIDINE; [2 (2,5 DIMETHOXYPHENYLTHIO) 5 METHOXYBENZYLIDENEAMINO]GUANIDINE; [2 (2,5 DIMETHOXYPHENYLTHIO) 5 NITROBENZYLIDENEAMINO]GUANIDINE; [2 (2,5 DIMETHOXYPHENYLTHIO) 6 METHOXYBENZYLIDENEAMINO]GUANIDINE; [2 (2,5 DIMETHOXYPHENYLTHIO)BENZYLIDENEAMINO] N 3 METHYLGUANIDINE; [2 (2,5 DIMETHOXYPHENYLTHIO)BENZYLIDENEAMINO]GUANIDINE; [2 (3 METHOXYPHENYLTHIO)BENZYLIDENEAMINO]GUANIDINE; [2 (3,4 DIMETHOXYPHENYLTHIO)BENZYLIDENEAMINO]GUANIDINE; [2 (4 METHOXYPHENYLTHIO)BENZYLIDENEAMINO]GUANIDINE; CASPASE; COLCHICINE; DOXORUBICIN; GUANIDINE DERIVATIVE; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER MODEL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYMERIZATION; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZYLIDENE COMPOUNDS; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; GUANIDINES; HUMANS; SEMICARBAZIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 62949180249     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.029     Document Type: Article

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