Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis

BMC Nephrology

Volumn 11, Issue 1, 2010, Pages

  Bramlage, Carsten P ^a   Tampe, Björn ^a   Koziolek, Michael ^a   Maatouk, Imad ^a   Bevanda, Jelena ^a   Bramlage, Peter ^b   Ahrens, Katharina ^b   Lange, Katharina ^a   Schmid, Holger ^c   Cohen, Clemens D ^d   Kretzler, Matthias ^e   Müller, Gerhard A ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Institute for Cardiovascular Pharmacology and Epidemiology   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; MESSENGER RNA; OSTEOGENIC PROTEIN 1; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TELMISARTAN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; BMP7 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CELL PROTECTION; CLINICAL ARTICLE; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSIVE NEPHROSCLEROSIS; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; MALE; NEPHROSCLEROSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; AGED; BIOSYNTHESIS; CELL LINE; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; HYPERTENSION; METABOLISM; MIDDLE AGED;

AGED; BONE MORPHOGENETIC PROTEIN 7; CELL LINE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NEPHROSCLEROSIS; RNA, MESSENGER;

EID: 78149492940     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-11-31     Document Type: Article

References (29)

1. [Bone morphogenetic proteins in the skeletal system]. CP Bramlage T Haupl C Kaps P Bramlage GA Muller F Strutz, Z Rheumatol 2005 64 6 416 422 10.1007/s00393-005-0665-0 16184350
2. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. G Mitu R Hirschberg, Front Biosci 2008 13 4726 4739 10.2741/3035 18508541
3. Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. S Vukicevic V Basic D Rogic N Basic MS Shih A Shepard D Jin B Dattatreyamurty W Jones H Dorai, et al. J Clin Invest 1998 102 1 202 214 10.1172/JCI2237 9649574
4. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. M Zeisberg J Hanai H Sugimoto T Mammoto D Charytan F Strutz R Kalluri, Nat Med 2003 9 7 964 968 10.1038/nm888 12808448
5. Modulator of bone morphogenetic protein activity in the progression of kidney diseases. M Yanagita, Kidney Int 2006 70 6 989 993 10.1038/sj.ki.5001731 16871237
6. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. C Kaps C Bramlage H Smolian A Haisch U Ungethum GR Burmester M Sittinger G Gross T Haupl, Arthritis Rheum 2002 46 1 149 162 10.1002/1529-0131(200201)46:1<149:: AID-ART10058>3.0.CO;2-W 11817587
7. BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells. SE Gould M Day SS Jones H Dorai, Kidney Int 2002 61 1 51 60 10.1046/j.1523-1755.2002.00103.x 11786084
8. Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron. P Wetzel J Haag V Campean R Goldschmeding A Atalla K Amann T Aigner, Kidney international 2006 70 4 717 723 10.1038/sj.ki.5001653 16807538
9. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. Y Xu J Wan D Jiang X Wu, J Nephrol 2009 22 3 403 410 19557718
10. Gene expression profiles of human proximal tubular epithelial cells in proteinuric nephropathies. M Rudnicki S Eder P Perco J Enrich K Scheiber C Koppelstatter G Schratzberger B Mayer R Oberbauer TW Meyer, et al. Kidney Int 2007 71 4 325 335 10.1038/sj.ki.5002043 17183245
11. BMP-7 fails to attenuate TGF-{beta}1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells. PL Dudas RL Argentieri FX Farrell, Nephrol Dial Transplant 2008 19056781
12. Age-related associations of hypertension and diabetes mellitus with chronic kidney disease. FC Islam TM D Mann P Munter, BMC Nephrology 2009 10 17 10.1186/1471-2369-10-17 19563681
13. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. MR Davies RJ Lund KA Hruska, J Am Soc Nephrol 2003 14 6 1559 1567 10.1097/01.ASN.0000068404.57780.DD 12761256
14. Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. CD Cohen K Frach D Schlondorff M Kretzler, Kidney Int 2002 61 1 133 140 10.1046/j.1523-1755.2002.00113.x 11786093
15. HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. MJ Ryan G Johnson J Kirk SM Fuerstenberg RA Zager B Torok-Storb, Kidney Int 1994 45 1 48 57 10.1038/ki.1994.6 8127021
16. Potential role of fractalkine receptor expression in human renal fibrogenesis. MJ Koziolek H Schmid CD Cohen S Blaschke B Hemmerlein A Zapf GA Muller F Strutz, Kidney Int 2007 72 5 599 607 10.1038/sj.ki.5002368 17579663 (Pubitemid 47312792)
17. Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients. MJ Koziolek R Riess H Geiger F Thevenod IA Hauser, Kidney Int 2001 60 1 156 166 10.1046/j.1523-1755.2001.00782.x 11422747
18. Validation of endogenous internal real-time PCR controls in renal tissues. X Cui J Zhou J Qiu MR Johnson M Mrug, Am J Nephrol 2009 30 5 413 417 10.1159/000235993 19729889
19. The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. MH Heeg MJ Koziolek R Vasko L Schaefer K Sharma GA Muller F Strutz, Kidney Int 2005 68 1 96 109 10.1111/j.1523-1755.2005.00384.x 15954899
20. Downregulation of the expression of bone morphogenetic protein 7 in experimental pyelonephritis. NK Biyikli H Tugtepe F Cakalagaoglu A Ilki H Alpay, Pediatr Nephrol 2005 20 9 1230 1236 10.1007/s00467-005-1927-4 16034630
21. Osteogenic Protein-1: gene expression and treatment in rat remnant kidney model. PH Dube MM Almanzar KS Frazier WK Jones MF Charette A Paredes, Toxicol Pathol 2004 32 4 384 392 10.1080/01926230490440925 15307210
22. Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy. SN Wang J Lapage R Hirschberg, J Am Soc Nephrol 2001 12 11 2392 2399 11675415
23. Isolation of proximal and distal tubule cells from human kidney by immunomagnetic separation. Technical note. PC Baer WA Nockher W Haase JE Scherberich, Kidney Int 1997 52 5 1321 1331 10.1038/ki.1997.457 9350655
24. Allelic depletion of grem1 attenuates diabetic kidney disease. SA Roxburgh JJ Kattla SP Curran YM O'Meara CA Pollock R Goldschmeding C Godson F Martin DP Brazil, Diabetes 2009 58 7 1641 1650 10.2337/db08-1365 19401426
25. Control of the bone morphogenetic protein 7 gene in developmental and adult life. L Oxburgh, Curr Genomics 2009 10 4 223 230 10.2174/ 138920209788488490 19949543
26. Inhibition of tumor necrosis factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome proliferator- activated receptor-gamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta. Q Tian R Miyazaki T Ichiki I Imayama K Inanaga H Ohtsubo K Yano K Takeda K Sunagawa, Hypertension 2009 53 5 798 804 10.1161/HYPERTENSIONAHA.108. 126656 19289654
27. Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats. Q Dai M Xu M Yao B Sun, Br J Pharmacol 2007 152 7 1042 1048 10.1038/sj.bjp.0707454 17922026
28. Differential regulation of E-cadherin and alpha-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis. M Veerasamy TQ Nguyen R Motazed AL Pearson R Goldschmeding ME Dockrell, Am J Physiol Renal Physiol 2009 297 5 1238 1248 10.1152/ajprenal. 90539.2008 19741012
29. Endocytic regulation of TGF-beta signaling. Y Chen, Cell Research 2009 19 1 58 70 10.1038/cr.2008.315 19050695