A cell-based screen for inhibitors of protein folding and degradation

Cell Stress and Chaperones

Volumn 15, Issue 6, 2010, Pages 913-927

  Boschelli, Frank ^a   Golas, Jennifer M ^a   Petersen, Roseann ^a   Lau, Vincent ^a   Chen, Lei ^a   Tkach, Diane ^a   Zhao, Qiang ^a   Fruhling, Dave S ^a   Liu, Hao ^a   Nam, Chaneun ^a   Arndt, Kim T ^a  

^a WYETH RESEARCH   (United States)

Author keywords

High throughput screen; Hsp70; Hsp90; Molecular chaperone; Ubiquitin pathway; v Src

Indexed keywords

GELDANAMYCIN; GEMCITABINE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; LUCIFERASE; MITOXANTRONE; PACLITAXEL; PHOSPHOTRANSFERASE;

ARTICLE; CANCER CELL; CELL STRESS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SYNTHESIS; UBIQUITINATION;

BENZOQUINONES; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LUCIFERASES, FIREFLY; MOLECULAR CHAPERONES; ONCOGENE PROTEIN PP60(V-SRC); PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN SYNTHESIS INHIBITORS; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; UBIQUITIN;

EID: 78149467224     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-010-0200-3     Document Type: Article

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