Identification of early molecular pathways affected by paraquat in rat lung

Toxicology

Volumn 225, Issue 2-3, 2006, Pages 157-172

  Mainwaring, Guy ^a   Lim, Fei Ling ^a   Antrobus, Kate ^a   Swain, Cindy ^a   Clapp, Mike ^a   Kimber, Ian ^a   Orphanides, George ^a   Moggs, Jonathan G ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Fibrosis; Gene; Lung; Methyl violgen; Microarray; Paraquat; Transcription

Indexed keywords

PARAQUAT; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENOME ANALYSIS; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; LUNG FIBROSIS; LUNG LOBE; LUNG TOXICITY; MALE; MEMBRANE TRANSPORT; MOLECULAR GENETICS; MOLECULAR PROBE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TRANSCRIPTION INITIATION;

ANIMALS; FIBROSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HERBICIDES; LUNG; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARAQUAT; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 33746277783     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.05.017     Document Type: Article

References (57)

1. Adam A., Smith L.L., and Cohen G.M. An evaluation of the redox cycling potencies of paraquat and nitofurantoin in microsomal and lung slice systems. Biochem. Pharmacol. 40 (1990) 1533-1539
2. Attisano L., Carcamo F., Ventura F.M., Weis F.M., Massague J., and Wrana J.L. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75 (1993) 671-680
3. Aulak K.S., Liu J., Wu J., Hyatt S.L., Puppi M., Henning S.J., and Hatzoglou M. Molecular sites of regulation of expression of the rat cationic amino acid transporter gene. J. Biol. Chem. 271 (1996) 29799-29806
4. Bartram U., and Speer C.P. The role of transforming growth factor beta in lung development and disease. Chest 125 (2004) 754-765
5. Baughman R.P., Lower E.E., Miller M.A., Bejarano P.A., and Heffelfinger S.C. Overexpression of transforming growth factor-alpha and epidermal growth factor-receptor in idiopathic pulmonary fibrosis. Sarcoidosis Vasc. Diffuse Lung Dis. 16 (1999) 57-61
6. Becker K.G., Hosack D.A., Dennis G.J.R., Lempicki R.A., Bright T.J., Cheadle C., and Engel J. PubMatrix: a tool for multiplex literature mining. BMC Bioinformatics 4 1 (2003) 61
7. Beissbarth T., and Speed T.P. GOstat: find statistically overrepresented gene ontologies within a group of genes. Bioinformatics 20 9 (2004) 1464-1465
8. Brigelius R., Dostal L.A., Horton J.K., and Bond J.R. Alteration of the redox state of NADPH and glutathione in perfused rabbit lung by paraquat. Toxicol. Ind. Health 2 (1986) 417-428
9. Bus J.S., Aust S.D., and Gibson J.E. Superoxide and singlet oxygen catalyses lipid peroxidation as a possible mechanism for paraquat (methyl Viologen) toxicity. Biochem. Biophys. Res. Commun. 58 (1974) 749-755
10. Bus J.S., Aust S.D., and Gibson J.E. Paraquat toxicity: proposed mechanism of action involving lipid peroxidation. Environ. Health Perspect. 16 (1976) 139-146
11. Chaussabe D., and Sher A. Mining microarray expression data by literature profiling. Genome Biol. 3 10 (2002) RESEARCH0055, Epub September 13, 2002
12. Chen C.M., Chou H.C., Hsu H.H., and Wang L.F. Transforming growth factor-beta1 upregulation is independent of angiotensin in paraquat-induced lung fibrosis. Toxicology 216 (2005) 181-187
13. Clark D.G., McElligott T.F., and Western Hurst E. The toxicity of paraquat. Br. J. Ind. Med. 23 (1966) 126-132
14. Coker R.K., and Laurent G.J. Pulmonary fibrosis: cytokines in the balance. Eur. Respir. J. 11 (1998) 1218-1221
15. Currie R.A., Bombail V., Oliver J.D., Moore D.J., Lim F.L., Gwilliam V., Kimber I., Chipman K., Moggs J.G., and Orphanides G. Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate. Toxicol. Sci. 86 (2005) 453-469
16. Curtis R.K., Matej O., and Vidal-Puig A. Pathways to the analysis of microarray data. Trends Biotechnol. 23 (2005) 429-435
17. de Haan J.B., Bladier C., Griffiths P., Kelner M., O'Shea R.D., Cheung N.S., Bronson R.T., Silvestro M.J., Wild S., Zheng S.S., Beart P.M., Hertzog P.J., and Kola I. Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J. Biol. Chem. 273 (1998) 22528-22536
18. Derynck R., and Zhang Y. Intracellular signalling: the mad way to do it. Curr. Biol. 6 (1996) 1226-1229
19. Edgar R., Domrachev M., and Lash A.E. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucl. Acids Res. 30 (2002) 207-210
20. Endo M., Oyadomari S., Terasaki Y., Takeya M., Suga M., Mori M., and Gotoh T. Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung. Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2003) L313-L321
21. Farrington J.A., Ebert M., Land E.J., and Fletcher K. Bipyridilium quaternary salts and related compounds. V. Pulse radiolysis studies on the reaction of paraquat radical with oxygen, implications for the mode of action of bipyridium herbicides. Biochim. Biophys. Acta 314 (1973) 372-381
22. Ferguson M.W., and O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos. Trans. Roy. Soc. Lond. B: Biol. Sci. 359 (2004) 839-850
23. Fisher H.K., Clements J.A., Tierney D.F., and Wright R.R. Pulmonary effects of paraquat in the first day after injection. Am. J. Physiol. 228 (1975) 1217-1223
24. Franzen P., Ten Dijke P., Ichijo H., Yamashita H., Schulz P., Heldin C.H., and Miyazono K. Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell 75 (1993) 681-692
25. Gabriel A., Kuddus R.H., Rao A.S., and Gandhi C.R. Down-regulation of endothelin receptors by transforming growth factor beta1 in hepatic stellate cells. J. Hepatol. 30 (1999) 440-450
26. Green F.H. Overview of pulmonary fibrosis. Chest 122 Suppl. 6 (2002) 334S-339S
27. Hardie W.D., Bejarano P.A., Miller M.A., Yankaskas J.R., Ritter J.H., Whitsett J.A., and Korfhagen T.R. Immunolocalization of transforming growth factor alpha and epidermal growth factor receptor in lungs of patients with cystic fibrosis. Pediatr. Dev. Pathol. 2 (1999) 415-423
28. Heldin C.H., Miyazono K., and Ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390 (1997) 465-471
29. Ishida Y., Takayasu T., Kimura A., Hayashi T., Kakimoto N., Miyashita T., and Kondo T. Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Leg. Med. (Tokyo) 8 (2006) 102-109
30. Kaminski N., Allard J.D., Pittet J.F., Zuo F., Griffiths M.J., Morris D., Huang X., Sheppard D., and Heller R.A. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 1778-1783
31. Keeling P.L., and Smith L.L. Relevance of NADPH depletion and mixed disulphides formation in rat lung to the mechanism of cell damage following paraquat administration. Biochem. Pharmacol. 31 (1982) 3243-3249
32. Keeling P.L., Smith L.L., and Aldridge W.N. The formation of mixed disulphides in rat lung following paraquat administration. Correlation with changes in intermediary metabolism. Biochem. Biophys. Acta 716 (1982) 249-257
33. Komura E., Tonetti C., Penard-Lacronique V., Chagraoui H., Lacout C., Lecouedic J.P., Rameau P., Debili N., Vainchenker W., and Giraudier S. Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression. Cancer Res. 65 (2005) 3281-3289
34. Kretzschmar M., and Massague J. SMADs: mediators and regulators of TGF-beta signaling. Curr. Opin. Genet. Dev. 8 (1998) 103-111
35. Lin H.Y., Wang X.F., Ng-Eaton E., Weinberg R.A., and Lodish H.F. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell 68 (1992) 775-785
36. Liu G., Loraine A.E., Shigeta R., Cline M., Cheng J., Valmeekam V., Sun S., Kulp D., and Siani-Rose M.A. NetAffx: Affymetrix probe sets and annotations. Nucl. Acids Res. 31 (2003) 82-86
37. Lock E.A., and Wilks M.F. Paraquat. In: Kreiger R.I. (Ed). Handbook of Pesticide Toxicology. 2nd ed. vol. 2 (2001), Academic Press 1559-1603 Agents
38. Madtes D.K., Elston A.L., Hackman R.C., Dunn A.R., and Clark J.G. Transforming growth factor-alpha deficiency reduces pulmonary fibrosis in transgenic mice. Am. J. Respir. Cell Mol. Biol. 20 (1999) 924-934
39. Mastruzzo C., Crimi N., and Vancheri C. Role of oxidative stress in pulmonary fibrois. Monaldi. Arch. Chest Dis. 57 (2002) 173-176
40. Moore B.B., Paine III R., Christensen P.J., Moore T.A., Sitterding S., Ngan R., Wilke C.A., Kuziel W.A., and Toews G.B. Protection from pulmonary fibrosis in the absence of CCR2 signaling. J. Immunol. 167 (2001) 4368-4377
41. Ogata T., and Manabe S. Correlation between lipid peroxidation and morphological manifestation of paraquat-induced lung injury in rats. Arch. Toxicol. 64 (1990) 7-13
42. O'Kane S., and Ferguson M.W. Transforming growth factor beta s and wound healing. Int. J. Biochem. Cell Biol. 29 (1997) 63-78
43. Park S.H., Saleh D., Giaid A., and Michel R.P. Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist. Am. J. Respir. Crit. Care Med. 156 2 Pt 1 (1997) 600-608
44. Park S.H. Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads. J. Biochem. Mol. Biol. 38 (2005) 9-16
45. Rose M.S., Smith L.L., and Wyatt I. Evidence for the energy-dependant accumulation of paraquat into rat lung. Nature 252 (1974) 314-315
46. Rose M.S., Lock E.A., Smith L.L., and Wyatt I. Paraquat accumulation: tissue and species specificity. Biochem. Pharmacol. 25 (1976) 419-423
47. Rose M.S., and Smith L.L. Tissue uptake of paraquat and diquat. Gen. Pharmacol. 8 (1977) 173-176
48. Satomi Y., Tsuchiya W., Mihara K., Ota M., Kasahara Y., and Akahori F. Gene expression analysis of the lung following paraquat administration in rats using DNA microarray. J. Toxicol. Sci. 29 (2004) 91-100
49. Slonim D.K. From patterns to pathways: gene expression data analysis comes of age. Nat. Genet. 32 Suppl. (2002) 502-508
50. Smith P. A light- and electron-microscope study of the pulmonary lesions induced in rats by paraquat. J. Pathol. 104 3 (1971) vii
51. Smith P., and Heath D. The ultrastructure and time sequence of the early stages of paraquat lung in rats. Pathology 114 (1974) 177-184
52. Smith P., and Heath D. The pathology of the lung in paraquat poisoning. J. Clin. Pathol. 28 Suppl. 9 (1975) 81-93
53. Smith L.L., Rose M.S., and Wyatt I. The pathology and biochemistry of paraquat. Ciba Found. Symp. 65 (1978) 321-341
54. Sykes B.I., Purchase I., and Smith L.L. Pulmonary ultrastructure after oral and intravenous dosage of paraquat to rats. J. Pathol. 121 4 (1977) 233-241
55. The Gene Ontology Consortium. Gene ontology: tool for the unification of biology. Nat. Genet. 25 (2000) 25-29
56. Tomitori H., Kashiwagi K., Asakawa T., Kakinuma Y., Michael A.J., and Igarashi K. Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem. J. 353 (2001) 681-688
57. Wyatt I., Soames A.R., Clay M.F., and Smith L.L. The accumulation and localisation of putrescine, spermidine, spermine and paraquat in the rat lung. In vitro and in vivo studies. Biochem. Pharamcol. 37 (1988) 1909-1918