CD4+ T-cell anergy induced by lin-CD117(c-kit) + stem cell-derived immature dendritic cells loaded with nuclear antigen derived from Trypanosoma equiperdum

Autoimmunity

Volumn 43, Issue 8, 2010, Pages 664-671

  Xia, Yumin ^a   Zhang, Yi ^b   Jiang, Shan ^a   Cheng, Hong ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

CD4 positive T lymphocytes; Clonal anergy; Dendritic cells; Nuclear antigen; Trypanosome

Indexed keywords

AUTOANTIBODY; B7 ANTIGEN; CD86 ANTIGEN; CELL NUCLEUS ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; STEM CELL FACTOR RECEPTOR;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CELL MATURATION; CELL PROLIFERATION; CLONAL ANERGY; COCULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; TRYPANOSOMA; TRYPANOSOMA EQUIPERDUM;

ANIMALS; ANTIGENS, NUCLEAR; CD4-POSITIVE T-LYMPHOCYTES; CLONAL ANERGY; CYTOKINES; DENDRITIC CELLS; FLOW CYTOMETRY; IMMUNOPHENOTYPING; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RATS, WISTAR; SPECIFIC PATHOGEN-FREE ORGANISMS; TRYPANOSOMA;

EID: 78149449623     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916931003674691     Document Type: Article

References (30)

1. +T-cell cross-tolerance by dendritic cells. Eur J Immunol 2009;39:2325-2330.
2. Koido S, Tanaka Y, Tajiri H, Gong J. Generation and functional assessment of antigen-specific T cells stimulated by fusions of dendritic cells and allogeneic breast cancer cells. Vaccine 2007;25:2610-2619.
3. Shlomchik MJ. Activating systemic autoimmunity: B's, T's, and tolls. Curr Opin Immunol 2009;21:626-633.
4. Deshmukh US, Bagavant H, Fu SM. Role of anti-DNA antibodies in the pathogenesis of lupus nephritis. Autoimmun Rev 2006;5:414-418.
5. Ueda Y, Sakane T, Tsunematsu T. Hyperreactivity ofactivated B cells to B-cell growth factor in patients with systemic lupus erythematosus. JImmunol 1989;143:3988-3993.
6. Chae BS, Shin TY. Immunoregulatory abnormalities of T cells and hyperreactivity of B cells in the in vitro immune response in pristane-induced lupus mice. Arch Pharm Res 2007;30: 191-198.
7. Bamboat ZM, Stableford JA, Plitas G, Burt BM, Nguyen HM, Welles AP, Gonen M, Young JW, DeMatteo RP. Human liver dendritic cells promote T-cell hyporesponsiveness. J Immunol 2009;182:1901-1911.
8. Bros M, Wiechmann N, Besche V, Castor T, Sudowe S, Grabbe S, Reske-Kunz AB. A novel plasmid DNA electro-poration method allows transfection ofmurine DC J Immunol Methods 2009;343:13-20.
9. Kuo YR, Huang CW, Goto S, Wang CT, Hsu LW, Lin YC, Yang KD, Chen CL, Lee WP. Alloantigen-pulsed host dendritic cells induce T-cell regulation and prolong allograft survival in a rat model ofhindlimb allotransplantation. J Surg Res 2009;153:317-325.
10. Salazar L, Aravena O, Abello P, Escobar A, Contreras-Levicoy J, Rojas-Colonelli N, Catalán D, Aguirre A, Zúñiga R, Pesce B, González C, Cepeda R, Cuchacovich M, Molina MC, Salazar-Onfray F, Delgado M, Toes RE, Aguillón JC. Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated den-dritic cells. Ann Rheum Dis 2008;67:1235-1241.
11. Xia S, Guo Z, Xu X, Yi H, Wang Q, Cao X. Hepatic microenvironment programs hematopoietic progenitor differ-entiation into regulatory dendritic cells, maintaining liver tolerance. Blood 2008;112:3175-3185.
12. Feng B, Inaba M, Lian Z, Cui Y, Toki J, Ito T, Jin T, Fan T, Yang G, Yu C, Kushida T, Ikehara S. Development ofmouse dendritic cells from lineage-negative c-kit(low) pluripotent hemopoietic stem cells in vitro. Stem Cells 2000;18:53-60.
13. Slukvin II, Vodyanik MA, Thomson JA, Gumenyuk ME, Choi KD. Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway. J Immunol 2006;176:2924-2932.
14. Svensson M. Isolation and culture of human hematopoietic progenitors for studies of dendritic cell biology. Methods Mol Biol 2009;531:187-202.
15. Xia YM, Ding GH, Xu SZ, Jiang S, Yang HX, Xiong LY. Induction of lupus-like renal damages by double stranded DNA derived from Trypanosoma equiperdum. Chin Med J 2006;119:1753-1756.
16. Gibson W, Crow M, Kearns J. Kinetoplast DNA minicircles are inherited from both parents in genetic crosses of Trypanosoma brucei. Parasitol Res 1997;83:483-488.
17. Schulz SM, Köhler G, Holscher C, Iwakura Y, Alber G. IL-17A is produced by Th17, gammadelta T cells and other CD4-lymphocytes during infection with Salmonella enterica serovar enteritidis and has a mild effect in bacterial clearance. Int Immunol 2008;20:1129-1138.
18. Youngblom JH, Youngblom JJ, Wilkinson J. Tele Presence confocal laser scanning microscopy. Microsc Microanal 2001; 7:241-248.
19. Fazekasova H, Golshayan D, Read J, Tsallios A, Tsang JY Dorling A, George AJ, Lechler RI, Lombardi G, Mirenda V. Regulation of rat and human T-cell immune response by pharmacologically modified dendritic cells. Transplantation 2009;87:1617-1628.
20. Yu Y, Arora A, Min W, Roifman CM, Grunebaum E. EdU incorporation is an alternative non-radioactive assay to [(3)H]thymidine uptake for in vitro measurement ofmice T-cell proliferations. J Immunol Methods 2009;350:29-35.
21. Lakey RL, Cawston TE. Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases. Rheumatology (Oxford) 2009;48:1208-1212.
22. Zhao Z, Weinstein E, Tuzova M, Davidson A, Mundel P, Marambio P, Putterman C. Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum 2005;52:522-530.
23. Xu SZ, Wang HZ, Li HJ. A new method for determination of anti-double strand DNA antibodies: Trypanosoma equiperdum immunofluorescent method. Chin Med J 1981;94:549-554.
24. Kuwana M. Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets. Hum Immunol 2002;63:1156-1163.
25. Philpott NJ, Nociari M, Elkon KB, Falck-Pedersen E. Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Proc Natl Acad Sci USA 2004;101:6200-6205.
26. Cheung WH, Chan VS, Pang HW, Wong MK, Guo ZH, Tam PK, Che CM, Lin CL, Yu WY. Conjugation of latent membrane protein (LMP)-2 epitope to gold nanoparticles as highly immunogenic multiple antigenic peptides for induction of Epstein-Barr virus-specific cytotoxic T-lymphocyte responses in vitro. Bioconjug Chem 2009;20:24-31.
27. + T-cell lineage differentiation. Immunity 2009;30:646-655.
28. Anderson KM, Czinn SJ, Redline RW, Blanchard TG. Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacterpyloriinfection. J Immunol 2006;176:5306-5313.
29. Gabrysová L, Nicolson KS, Streeter HB, Verhagen J, Sabatos-Peyton CA, Morgan DJ, Wraith DC Negative feedback control of the autoimmune response through antigen-induced differentiation ofIL-10-secreting Th1 cells. J Exp Med 2009; 206:1755-1767.
30. Knoechel B, Lohr J, Zhu S, Wong L, Hu D, Ausubel L, Abbas AK. Functional and molecular comparison of anergic and regulatory T lymphocytes. J Immunol 2006;176: 6473-6483.