Real-time dynamics of Ca2+, caspase-3/7, and morphological changes in retinal ganglion cell apoptosis under elevated pressure

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Lee, Jae Kyoo ^a   Lu, Siyuan ^b,c   Madhukar, Anupam ^a,b  

^a University of Southern California   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 7; ION CHANNEL; CALCIUM;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL COUNT; CELL DIFFERENTIATION; CELL POPULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HYDROSTATIC PRESSURE; IMAGING SYSTEM; MITOCHONDRION; MOLECULAR DYNAMICS; NEURITE; NONHUMAN; RAT; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; WATER TRANSPORT; ANIMAL; CELL LINE; CYTOLOGY; GANGLION; METABOLISM; PRESSURE; RETINA;

ANIMALS; APOPTOSIS; CALCIUM; CASPASE 3; CASPASE 7; CELL LINE; GANGLIA; PRESSURE; RETINA;

EID: 78149442885     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013437     Document Type: Article

References (43)

1. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257.
2. Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516.
3. Boehning D, Patterson RL, Sedaghat L, Glebova NO, Kurosaki T, et al. (2003) Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol 5: 1051-1061.
4. Degterev A, Boyce M, Yuan J (2003) A decade of caspases. Oncogene 22: 8543-8567.
5. Fussenegger M, Bailey JE, Varner J (2000) A mathematical model of caspase function in apoptosis. Nat Biotechnol 18: 768-774.
6. Bentele M, Lavrik I, Ulrich M, Stosser S, Heermann DW, et al. (2004) Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol 166: 839-851.
7. Paulsson JF, Schultz SW, Kohler M, Leibiger I, Berggren PO, et al. (2008) Realtime monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation. Exp Diabetes Res 2008: 865850.
8. Zhou LL, Zhou LY, Luo KQ, Chang DC (2005) Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis. Apoptosis 10: 289-299.
9. Lee DA, Higginbotham EJ (2005) Glaucoma and its treatment: a review. Am J Health Syst Pharm 62: 691-699.
10. Agar A, Li S, Agarwal N, Coroneo MT, Hill MA (2006) Retinal ganglion cell line apoptosis induced by hydrostatic pressure. Brain Res 1086: 191-200.
11. Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, et al. (2005) Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOPinduced effects on extracellular matrix. Invest Ophthalmol Vis Sci 46: 175-182.
12. Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ (2000) Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci 41: 764-774.
13. Krishnamoorthy RR, Agarwal P, Prasanna G, Vopat K, Lambert W, et al. (2001) Characterization of a transformed rat retinal ganglion cell line. Brain Res Mol Brain Res 86: 1-12.
14. Liu Q, Ju WK, Crowston JG, Xie F, Perry G, et al. (2007) Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. Invest Ophthalmol Vis Sci 48: 4580-4589.
15. Ju WK, Liu Q, Kim KY, Crowston JG, Lindsey JD, et al. (2007) Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci 48: 2145-2151.
16. Ju WK, Kim KY, Lindsey JD, Angert M, Patel A, et al. (2009) Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis 15: 120-134.
17. Mattson MP, Chan SL (2003) Calcium orchestrates apoptosis. Nat Cell Biol 5: 1041-1043.
18. Slee EA, Adrain C, Martin SJ (2001) Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276: 7320-7326.
19. Assefa Z, Bultynck G, Szlufcik K, Nadif Kasri N, Vermassen E, et al. (2004) Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis. J Biol Chem 279: 43227-43236.
20. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, et al. (1997) Caspase-3- generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278: 294-298.
21. Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y (2000) Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci U S A 97: 9487-9492.
22. Moorhouse AJ, Li S, Vickery RM, Hill MA, Morley JW (2004) A patch-clamp investigation of membrane currents in a novel mammalian retinal ganglion cell line. Brain Res 1003: 205-208.
23. Van Bergen NJ, Wood JP, Chidlow G, Trounce IA, Casson RJ, et al. (2009) Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci 50: 4267-4272.
24. Gross RL, Ji J, Chang P, Pennesi ME, Yang Z, et al. (2003) A mouse model of elevated intraocular pressure: retina and optic nerve findings. Trans Am Ophthalmol Soc 101: 163-169; discussion 169-171.
25. Frassetto LJ, Schlieve CR, Lieven CJ, Utter AA, Jones MV, et al. (2006) Kinasedependent differentiation of a retinal ganglion cell precursor. Invest Ophthalmol Vis Sci 47: 427-438.
26. Das A, Garner DP, Del Re AM, Woodward JJ, Kumar DM, et al. (2006) Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx. Brain Res 1084: 146-157.
27. Cellerino A, Galli-Resta L, Colombaioni L (2000) The dynamics of neuronal death: a time-lapse study in the retina. J Neurosci 20: RC92.
28. Sappington RM, Sidorova T, Long DJ, Calkins DJ (2009) TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci 50: 717-728.
29. Niittykoski M, Kalesnykas G, Larsson K, Kaarniranta K, Akerman K, et al. (2010) Altered calcium signalling in an experimental model of glaucoma. Invest Ophthalmol Vis Sci.
30. Iglewicz B, Hoaglin DC (1993) How to Detect and Handle Outliers. MilwaukeeWI: ASQ Quality Press. pp 32-33.
31. Rosner B (2006) Fundamentals of Biostatistics. BelmontCA: Duxbury Press. Pp 328-329.
32. Campbell AK (1983) Intracellular Calcium, Its Universal Role as Regulator. Chichester: Wiley, John & Sons.
33. Berridge MJ, Bootman MD, Lipp P (1998) Calcium-a life and death signal. Nature 395: 645-648.
34. Falcke M (2004) Reading the patterns in living cells - the physics of Ca2+ signaling. Advances in Physics 53: 255-440.
35. Friel DD (1995) [Ca2+]i oscillations in sympathetic neurons: an experimental test of a theoretical model. Biophys J 68: 1752-1766.
36. Shen P, Larter R (1995) Chaos in intracellular Ca2+ oscillations in a new model for non-excitable cells. Cell Calcium 17: 225-232.
37. Florea AM, Dopp E, Busselberg D (2005) Elevated Ca2+(i) transients induced by trimethyltin chloride in HeLa cells: types and levels of response. Cell Calcium 37: 251-258.
38. Oshimi Y, Oshimi K, Miyazaki S (1996) Necrosis and apoptosis associated with distinct Ca2+ response patterns in target cells attacked by human natural killer cells. J Physiol 495(Pt 2): 319-329.
39. Gerasimenko JV, Gerasimenko OV, Palejwala A, Tepikin AV, Petersen OH, et al. (2002) Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore. J Cell Sci 115: 485-497.
40. Li YX, Keizer J, Stojilkovic SS, Rinzel J (1995) Ca2+ excitability of the ER membrane: an explanation for IP3-induced Ca2+ oscillations. Am J Physiol 269: C1079-1092.
41. Nietsch HH, Roe MW, Fiekers JF, Moore AL, Lidofsky SD (2000) Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death. J Biol Chem 275: 20556-20561.
42. Krick S, Platoshyn O, Sweeney M, Kim H, Yuan JX (2001) Activation of K+ channels induces apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 280: C970-979.
43. Raychaudhuri S, Willgohs E, Nguyen TN, Khan EM, Goldkorn T (2008) Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis. Biophys J 95: 3559-3562.