Some observations on the effects of bioprocessing on biopolymer stability

Journal of Drug Targeting

Volumn 18, Issue 10, 2010, Pages 732-740

  Harding, Stephen E ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Aggregation; Antibodies; Degradation; Freeze thaw; Irradiation.; Polysaccharides; Storage; Thermal

Indexed keywords

ALGINIC ACID; AMYLOSE; BIOPOLYMER; CARBOXYMETHYLCELLULOSE; CARRAGEENAN; CHITOSAN; GLUCAN; GLYCOCONJUGATE VACCINE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G4 ANTIBODY; MACROGOL; PECTIN; POLYSACCHARIDE VACCINE; STARCH; UNCLASSIFIED DRUG; VACCINE;

BIODEGRADATION; BIOPROCESSING; CHEMICAL REACTION; COLON CANCER; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG STABILITY; DRUG STORAGE; FREEZING; GAMMA RADIATION; GEL PERMEATION CHROMATOGRAPHY; GUAR; LIGHT SCATTERING; MACROMOLECULE; MENINGITIS; MOLECULAR STABILITY; MOLECULAR WEIGHT; PEGYLATION; PRIORITY JOURNAL; PROCESSING; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN PROCESSING; RADIATION STERILIZATION; REVIEW; THAWING; ULTRACENTRIFUGE; VISCOMETRY;

ANTIBODIES, MONOCLONAL; CARBOHYDRATES; DRUG STABILITY; DRUG STORAGE; HYDROGELS; IMMUNOGLOBULIN G; PEPTIDES; POLYMERS; POLYSACCHARIDES; PROTEINS; STERILIZATION;

EID: 78149442222     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2010.512470     Document Type: Review

References (54)

1. Anderson MT, Harding SE, Davis SS. (1989). On the interaction in solution of a candidate mucoadhesive polymer, diethylaminoethyldextran, with pig gastric mucus glycoprotein. Biochem Soc Trans, 17, 1101-1102.
2. Aspden TJ, Illum L, Skaugrud, Ø (1996). Chitosan as a nasal delivery system: Evaluation of insulin absorption enhancement and effect on nasal membrane integrity using rat models. Eur J Pharm Sci, 4, 23-31.
3. Bradley TD, Mitchell JR. (1988). The determination of the kinetics of polysaccharide thermal degradation using high temperature viscosity measurements, Carbohyd Polym, 9, 257-267.
4. Brange J. (2000). Physical stability of proteins. In Frokjaer S, Hovgaards L eds. Pharmaceutical Formulation & Development of Peptides & Proteins, Taylor and Francis, London, p 89-112.
5. Chi EY, Krishnan S, Randolph TW, Carpenter JF. (2003). Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation. Pharm Res, 20, 1325-1336.
6. Cleland JL, Powell MF, Shire SJ. (1993). The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation. Crit Rev Ther Drug Carrier Syst, 10, 307-377.
7. Davis SS, Illum L, Tomlinson E, eds. Plenum, New York.
8. Deacon MP, Davis SS, Waite JH, Harding SE. (1998). Structure and mucoadhesion of mussel glue protein in dilute solution. Biochemistry, 37, 14108-14112.
9. Deacon MP, Davis SS, White RJ, Nordman H, Carlstedt I, Errington N, Rowe AJ, Harding SE. (1999). Are chitosan-mucin interactions specific to different regions of the stomach? Velocity ultracentrifugation offers a clue. Carbohyd Polym, 38, 235-238.
10. Deacon MP, Davis SS, White R, Waite JH, Harding SE. (1997). Monomeric behaviour of Mytilus edulis (mussel) glue protein in dilute solution. Biochem Soc Trans, 25, 422S.
11. Deacon MP, McGurk S, Roberts CJ, Williams PM, Tendler SJ, Davies MC, Davis SS, Harding SE. (2000). Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems. Biochem J, 348 Pt 3, 557-563.
12. Errington N, Harding SE, Illum L, Schact EH. (1992). Physico-chemical studies on di-iodotyrosine dextran. Carbohyd Polym, 18, 611-613.
13. Errington N, Harding SE, Vårum KM, Illum L. (1993). Hydrodynamic characterization of chitosans varying in degree of acetylation. Int J Biol Macromol, 15, 113-117
14. Fee M. (2005). Evaluation of Chitosan Stability in Aqueous Systems, PhD Dissertation, University of Nottingham.
15. Fee M, Errington N, Jumel K, Illum L, Smith A, Harding SE. (2003). Correlation of SEC/MALLS with ultracentrifuge and viscometric data for chitosans. Eur Biophys J, 32, 457-464.
16. Fiebrig I, Davis SS, Harding SE. (1995a). Methods used to develop mucoadhesive drug delivery systems: Bioadhesion in the gastrointestinal tract In: Biopolymer Mixtures (Harding SE, Hill SE, Mitchell JR eds). Nottingham University Press, Nottingham, Chapter 18.
17. Fiebrig I, Harding SE, Rowe AJ, Hyman SC, Davis SS. (1995b). Transmission electron microscopy studies on pig gastric mucin and its interactions with chitosan. Carbohyd Polym, 28, 239-244.
18. Fiebrig I, Harding SE, Stokke BT, Vårum KM, Jordan D, Davis SS. (1994). The potential of chitosan as a mucoadhesive drug carrier: studies on its interaction with pig gastric mucin on a molecular level. Eur J Pharm Sci, 2, 185.
19. Fiebrig I, Vårum KM, Harding SE, Davis SS, Stokke BT. (1997). Colloidal gold and colloidal gold labelled wheat germ agglutinin as molecular probes for identification in mucin/chitosan complexes. Carbohyd Polym, 33, 91-99.
20. Fujita H. (1962). Mathematical Theory of Sedimentation Analysis, Academic Press, New York.
21. Ghong Y, Wang C, Lai RC, Su K, Zhang F, Wang D. (2009). An improved injectable polysaccharide hydrogel: modified gellan gum for long-term cartilage regeneration in vitro. J Material Chem, 19, 1968-1977.
22. Goolcharran C, Khossravi M, Borchardt R. (2000). Chemical pathways of peptide & protein degradation. In Frokjaer S, Hovgaards L, eds Pharmaceutical Formulation and Development of Peptides and Proteins, Taylor and Francis, London, p 70-88.
23. Greenwood CT, MacKenzie C. (1963). The irradiation of starch. Die Stä;rke, 15, 444-448.
24. Hagan SA, Coombes AG, Garnett MC, Dunn SE, Davies MC, Illum L, Davis SS, Harding SE, Irving M, Purkiss S. (1996). Polyactidepoly( ethylene glycol) (PLA-PEG) copolymers as drug delivery systems. 1. Characterisation of water dispersible micelle-forming systems. Langmuir, 12, 2153-2161.
25. Harding SE. (1989). The macrostructure of mucus glycoproteins in solution. Adv Carbohydr Chem Biochem, 47, 345-381.
26. Harding SE. (2003). Mucoadhesive interactions. Biochem Soc Trans, 31, 1036-1041.
27. Harding SE. (2006). Trends in mucoadhesive analysis. Trends Food Sci Tech, 17, 255-262.
28. Harding SE, Abdelhameed AS, Morris GA. (2010). Molecular Weight Distribution Evaluation of Polysaccharides and Glycoconjugates Using Analytical Ultracentrifugation. Macromol Biosci, 10, 714-720.
29. Harding SE, Davis SS, Deacon MP, Fiebrig I. (1999). Biopolymer mucoadhesives. Biotechnol Genet Eng Rev, 16, 41-86.
30. He P, Davis SS, Illum L. (1998). In vitro evaluation of mucoadhesive properties of chitosan microspheres. Int J Pharm, 166, 75-88.
31. Illum L. (1998). Chitosan and its use as a pharmaceutical excipient. Pharm Res, 15, 1326-1331.
32. Illum L, Jabbal-Gill I, Hinchcliffe M, Fisher AN, Davis SS. (2001). Chitosan as a novel nasal delivery system for vaccines. Adv Drug Deliv Rev, 51, 81-96.
33. Jumel K, Harding SE, Mitchell JR. (1996). The effect of gammairradiation on the macromolecular integrity of guar gum. Carbohyd Res, 282, 223-236.
34. Longman E, Harding SE, Marheineke N. (2005). Identifying differences in solution conformation of two chimeric IgG3 antibodies through triple detection SEC, LCGC 18, 662-668.
35. Lu Y, Harding SE, Rowe AJ, Davis KG, Fish B, Varley P, Gee C, Mulot S. (2008a). The effect of a point mutation on the stability of IgG4 as monitored by analytical ultracentrifugation. J Pharm Sci, 97, 960-969.
36. Lu Y, Harding SE, Turner A, Smith B, Athwal DS, Grossmann JG, Davis KG, Rowe AJ. (2008b). Effect of PEGylation on the solution conformation of antibody fragments. J Pharm Sci, 97, 2062-2079.
37. Manning MC, Patel K, Borchardt RT. (1989). Stability of protein pharmaceuticals. Pharm Res, 6, 903-918.
38. Melia CD. (1991). Hydrophilic matrix sustained release systems based on polysaccharide carriers. Crit Rev Ther Drug Carrier Syst, 8, 395-421.
39. Morris GA, Butler SNG, Foster TJ, Jumel K, Harding SE. (1999). Elevated temperature analytical ultracentrifugation of a lowmethoxy polyuronide, Prog Coll Polym Sci, 113, 205-208.
40. Morris GA, FosterTJ, Harding SE. (2002). A hydrodynamic study of the depolymerisation of a high methoxy pectin at elevated temperatures. Carbohyd Polym, 48, 361-367.
41. Morris GA, Patel TR, Picout DR, Ross-Murphy SB, Ortega A, Garcia de la Torre J, Harding SE. (2008). Global hydrodynamic analysis of the molecular flexibility of galactomannans. Carbohyd Polym, 72, 356-360.
42. Murray DR. (1990). Biology of Food Irradiation, Research Studies Press, Staunton, UK
43. Ortega A, García de la Torre J. (2007). Equivalent radii and ratios of radii from solution properties as indicators of macromolecular conformation, shape, and flexibility. Biomacromolecules, 8, 2464-2475.
44. Patel, TR, Moris GA, Ebringerova A, Vodenicarova M, Ortega A, Garcia de la Torre J., Harding SE. (2008). Global conformation analysis of irradiated xyloglucans. Carbohyd Polym, 74, 845-851.
45. Patel TR, Picout DR, Ross-Murphy SB, Harding SE. (2006). Pressure cell assisted solution characterization of galactomannans. 3. Application of analytical ultracentrifugation techniques. Biomacromolecules, 7, 3513-3520.
46. Petricek I, Berta A, Higazy MT, Németh J, Prost ME. (2008). Hydroxypropyl-guar gellable lubricant eye drops for dry eye treatment. Expert Opin Pharmacother, 9, 1431-1436.
47. Picout DR, Ross-Murphy SB, Errington N, Harding SE. (2001). Pressure cell assisted solution characterization of polysaccharides. 1. Guar gum. Biomacromolecules, 2, 1301-1309.
48. Remmele RL Jr, Callahan WJ, Krishnan S, Zhou L, Bondarenko PV, Nichols AC, Kleemann GR, Pipes GD, Park S, Fodor S, Kras E, Brems DN. (2006). Active dimer of Epratuzumab provides insight into the complex nature of an antibody aggregate. J Pharm Sci, 95, 126-145.
49. Roberts CJ, Shivji A, Davies MC, Davis SS, Fiebrig I, Harding SE, Tendler SJB, Williams, PM. (1995). A Study of Highly Purified Pig Gastric Mucin by Scanning Tunnelling Microscopy. Prot Peptide Lett, 2, 409-414.
50. Scott DJ, Harding SE, Rowe AJ. (2005). Analytical Ultracentrifugation Techniques and Methods, Royal Society of Chemistry, Cambridge.
51. Suker J, Corbel MJ, Jones C, Feavers IM, Bolgiano B. (2004). Standardisation and control of meningococcal C conjugate vaccines, Expert Rev Vaccines, 3, 89-96.
52. Tombs MP, Harding SE. (1998). An Introduction to Polysaccharide Biotechnology, Taylor and Francis, London.
53. Wandrey C, Bartkowiak A, Harding SE. (2009). Materials for encapsulation. In Zuidam, NJ, Nedovic V, eds Encapsulation Technologies for Active Food Ingredients and Food Processing, Springer, New York, p 31-100.
54. Wang W. (2005). Protein aggregation and its inhibition in biopharmaceutics. Int J Pharm, 289, 1-30.