Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis

Molecular Biology Reports

Volumn 37, Issue 8, 2010, Pages 4091-4101

  Song, Zhi ^a   Li, Ren ^a   You, Nan ^a   Tao, Kaishan ^a   Dou, Kefeng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; Loss of heterozygosity; Microsatellite marker; Tg737 gene

Indexed keywords

TG737 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CARCINOMA CELL; CELL POPULATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; METASTASIS; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PROGNOSIS; SHORT TANDEM REPEAT; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; FEMALE; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PROGNOSIS; SIDE-POPULATION CELLS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 78149421791     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0069-3     Document Type: Article

References (73)

1. Parkin DM, Pisani P, Ferlay J (1999) Global cancer statistics. CA Cancer J Clin 49:33-64, 31
2. Fu X, Wang Q, Chen J, Huang X, Chen X, Cao L, Tan H, Li W, Zhang L, Bi J, Su Q, Chen L (2010) Clinical significance of miR-221 and its inverse correlation with p27(Kip1) in hepatocellular carcinoma. Mol Biol Rep. doi: 10.1007/s11033-010-9969-5
3. N Zhu Y Shao L Xu L Yu L Sun 2009 Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells Mol Biol Rep 36 2075 2085 1:CAS:528:DC%2BD1MXht1yrs7jJ 10.1007/s11033-008-9419-9 19048389
4. L Sun R Gong B Wan X Huang C Wu X Zhang S Zhao L Yu 2003 GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 Chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines Mol Biol Rep 30 249 253 1:CAS:528:DC%2BD3sXosFWqu7k%3D 10.1023/A:1026370726763 14672412 (Pubitemid 37462617)
5. Q Li W Yan S Cheng S Guo W Wang Z Zhang L Wang J Zhang 2006 Introduction of G1 phase arrest in human hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21 Mol Biol Rep 33 257 263 10.1007/s11033-006-9007-9 17080297 (Pubitemid 44760395)
6. Z Zhang L Han Y Liu X Liang W Sun 2009 Up-regulation of tropomyosin related kinase B contributes to resistance to detachment-induced apoptosis in hepatoma multicellular aggregations Mol Biol Rep 36 1211 1216 1:CAS:528:DC%2BD1MXjvFejs70%3D 10.1007/s11033-008-9299-z 18595003
7. H Elmileik AC Paterson MC Kew 2005 Beta-catenin mutations and expression, 249 serine p53 tumor suppressor gene mutation, and hepatitis B virus infection in southern African Blacks with hepatocellular carcinoma J Surg Oncol 91 258 263 1:CAS:528:DC%2BD2MXhtVGlt7vJ 10.1002/jso.20304 16121349 (Pubitemid 41266823)
8. GN Zhu L Zuo Q Zhou SM Zhang HQ Zhu SY Gui Y Wang 2004 Loss of heterozygosity on chromosome 10q22-10q23 and 22q11.2-22q12.1 and p53 gene in primary hepatocellular carcinoma World J Gastroenterol 10 1975 1978 1:CAS:528:DC%2BD2cXmslWrtbg%3D 15222050
9. MC Yakicier MB Irmak A Romano M Kew M Ozturk 1999 Smad2 and Smad4 gene mutations in hepatocellular carcinoma Oncogene 18 4879 4883 1:CAS:528: DyaK1MXlvFynsLk%3D 10.1038/sj.onc.1202866 10490821 (Pubitemid 29423571)
10. X Zhang HJ Xu Y Murakami R Sachse K Yashima S Hirohashi SX Hu WF Benedict T Sekiya 1994 Deletions of chromosome 13q, mutations in retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma Cancer Res 54 4177 4182 1:CAS:528:DyaK2cXltVGmt78%3D 8033150
11. Y Chen X Tang X Zhang L Zhuang 2009 New mutations of Nogo-C in hepatocellular carcinoma Mol Biol Rep 36 377 380 1:CAS:528:DC%2BD1cXhsFCmsLfO 10.1007/s11033-007-9190-3 18080785
12. Zhang YQ, Li KN, Cui JH, Liu YF, Yang SJ (2010) Abnormal expression of NRF-2alpha in hepatocellular carcinoma identified with a newly prepared monoclonal antibody against human NRF-2alpha protein. Mol Biol Rep. doi: 10.1007/s11033-010-9976-6
13. K Fukai O Yokosuka F Imazeki M Tada R Mikata M Miyazaki T Ochiai H Saisho 2005 Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma Liver Int 25 1209 1216 1:CAS:528:DC%2BD28XkslSrtg%3D%3D 10.1111/j.1478-3231.2005.01162.x 16343074 (Pubitemid 41782567)
14. LS Hsu HC Lee GY Chau PH Yin CW Chi WY Lui 2006 Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan Oncol Rep 15 507 511 1:CAS:528:DC%2BD28XhsFSrtr4%3D 16391877
15. J Gisin A Perren M Bawohl W Jochum 2005 Rare allelic imbalances, but no mutations of the PRDX1 gene in human hepatocellular carcinomas J Clin Pathol 58 1229 1231 1:CAS:528:DC%2BD2MXht1Kku7zM 10.1136/jcp.2004.024679 16254121 (Pubitemid 41566476)
16. T Mori S Nomoto K Koshikawa T Fujii M Sakai Y Nishikawa S Inoue S Takeda T Kaneko A Nakao 2005 Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma Liver Int 25 380 388 1:CAS:528:DC%2BD2MXjs1Ogsbs%3D 10.1111/j.1478-3231.2005.1059.x 15780064
17. I Tischoff A Markwarth H Witzigmann D Uhlmann J Hauss A Mirmohammadsadegh C Wittekind UR Hengge A Tannapfel 2005 Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors Int J Cancer 115 684 689 1:CAS:528:DC%2BD2MXkvF2ksrc%3D 10.1002/ijc.20944 15704097 (Pubitemid 40776690)
18. M Anzola N Cuevas M Lopez-Martinez M Martinez de Pancorbo JJ Burgos 2004 p16INK4A gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy J Gastroenterol Hepatol 19 397 405 1:CAS:528:DC%2BD2cXktlKnsLY%3D 10.1111/j.1440-1746.2003.03305.x 15012776 (Pubitemid 38570189)
19. S Kremer-Tal HL Reeves G Narla SN Thung M Schwartz A Difeo A Katz J Bruix P Bioulac-Sage JA Martignetti SL Friedman 2004 Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma Hepatology 40 1047 1052 1:CAS:528:DC%2BD2cXhtVCgt7zF 10.1002/hep.20460 15486921 (Pubitemid 39425559)
20. CF Chen SH Yeh DS Chen PJ Chen YS Jou 2005 Molecular genetic evidence supporting a novel human hepatocellular carcinoma tumor suppressor locus at 13q12.11 Genes Chromosomes Cancer 44 320 328 1:CAS:528:DC%2BD2MXhtFSrsrjK 10.1002/gcc.20247 16075462 (Pubitemid 41397101)
21. PJ Fialkow 1979 Clonal origin of human tumors Annu Rev Med 30 135 143 1:STN:280:DyaL3M3otVGnsA%3D%3D 10.1146/annurev.me.30.020179.001031 400484
22. B Vogelstein ER Fearon SR Hamilton AP Feinberg 1985 Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors Science 227 642 645 1:CAS:528:DyaL2MXhtVOgur0%3D 10.1126/science.2982210 2982210
23. M Al-Hajj MS Wicha A Benito-Hernandez SJ Morrison MF Clarke 2003 Prospective identification of tumorigenic breast cancer cells Proc Natl Acad Sci USA 100 3983 3988 1:CAS:528:DC%2BD3sXivFSqtbs%3D 10.1073/pnas.0530291100 12629218 (Pubitemid 36418143)
24. NA Lobo Y Shimono D Qian MF Clarke 2007 The biology of cancer stem cells Annu Rev Cell Dev Biol 23 675 699 1:CAS:528:DC%2BD2sXhtlartrrK 10.1146/annurev.cellbio.22.010305.104154 17645413
25. R Pardal MF Clarke SJ Morrison 2003 Applying the principles of stem-cell biology to cancer Nat Rev Cancer 3 895 902 1:CAS:528:DC%2BD3sXpvFahs7o%3D 10.1038/nrc1232 14737120
26. T Reya SJ Morrison MF Clarke IL Weissman 2001 Stem cells, cancer, and cancer stem cells Nature 414 105 111 1:CAS:528:DC%2BD3MXot1ahs7c%3D 10.1038/35102167 11689955 (Pubitemid 33041634)
27. I Falciatori G Borsellino N Haliassos C Boitani S Corallini L Battistini G Bernardi M Stefanini E Vicini 2004 Identification and enrichment of spermatogonial stem cells displaying side-population phenotype in immature mouse testis FASEB J 18 376 378 1:CAS:528:DC%2BD2cXht1Gjt7c%3D 14688197
28. MA Goodell K Brose G Paradis AS Conner RC Mulligan 1996 Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo J Exp Med 183 1797 1806 1:CAS:528:DyaK28XisFemsLw%3D 10.1084/jem.183.4. 1797 8666936 (Pubitemid 26134320)
29. K Shimano M Satake A Okaya J Kitanaka N Kitanaka M Takemura M Sakagami N Terada T Tsujimura 2003 Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1 Am J Pathol 163 3 9 1:CAS:528:DC%2BD3sXmtVWrt7w%3D 12819005
30. S Yano Y Ito M Fujimoto TS Hamazaki K Tamaki H Okochi 2005 Characterization and localization of side population cells in mouse skin Stem Cells 23 834 841 1:CAS:528:DC%2BD2MXlslCltbg%3D 10.1634/stemcells.2004-0226 15917479 (Pubitemid 40791798)
31. M Kim CM Morshead 2003 Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis J Neurosci 23 10703 10709 1:CAS:528:DC%2BD3sXpsFGju7w%3D 14627655
32. CM Martin AP Meeson SM Robertson TJ Hawke JA Richardson S Bates SC Goetsch TD Gallardo DJ Garry 2004 Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart Dev Biol 265 262 275 1:CAS:528:DC%2BD3sXhtVShsr3P 10.1016/j.ydbio.2003.09.028 14697368 (Pubitemid 38018836)
33. AP Meeson TJ Hawke S Graham N Jiang J Elterman K Hutcheson JM Dimaio TD Gallardo DJ Garry 2004 Cellular and molecular regulation of skeletal muscle side population cells Stem Cells 22 1305 1320 1:CAS:528:DC%2BD2MXks1ehtA%3D%3D 10.1634/stemcells.2004-0077 15579648 (Pubitemid 39636406)
34. T Chiba K Kita YW Zheng O Yokosuka H Saisho A Iwama H Nakauchi H Taniguchi 2006 Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties Hepatology 44 240 251 1:CAS:528:DC%2BD28XnsFWjur0%3D 10.1002/hep.21227 16799977 (Pubitemid 44049156)
35. N Haraguchi T Utsunomiya H Inoue F Tanaka K Mimori GF Barnard M Mori 2006 Characterization of a side population of cancer cells from human gastrointestinal system Stem Cells 24 506 513 1:CAS:528:DC%2BD28XhtFKitbvL 10.1634/stemcells.2005-0282 16239320 (Pubitemid 44464754)
36. C Hirschmann-Jax AE Foster GG Wulf JG Nuchtern TW Jax U Gobel MA Goodell MK Brenner 2004 A distinct "side population" of cells with high drug efflux capacity in human tumor cells Proc Natl Acad Sci USA 101 14228 14233 1:CAS:528:DC%2BD2cXosVyltr8%3D 10.1073/pnas.0400067101 15381773 (Pubitemid 39305058)
37. T Kondo T Setoguchi T Taga 2004 Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line Proc Natl Acad Sci USA 101 781 786 1:CAS:528:DC%2BD2cXhsVWhurc%3D 10.1073/pnas.0307618100 14711994 (Pubitemid 38121035)
38. PP Szotek R Pieretti-Vanmarcke PT Masiakos DM Dinulescu D Connolly R Foster D Dombkowski F Preffer DT Maclaughlin PK Donahoe 2006 Ovarian cancer side population defines cells with stem cell-like characteristics and mullerian inhibiting substance responsiveness Proc Natl Acad Sci USA 103 11154 11159 1:CAS:528:DC%2BD28XnvVamurs%3D 10.1073/pnas.0603672103 16849428 (Pubitemid 44156488)
39. TA Rege JS Hagood 2006 Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis FASEB J 20 1045 1054 1:CAS:528:DC%2BD28XlvFShtLo%3D 10.1096/fj.05-5460rev 16770003 (Pubitemid 44943900)
40. YY Dan KJ Riehle C Lazaro N Teoh J Haque JS Campbell N Fausto 2006 Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages Proc Natl Acad Sci USA 103 9912 9917 1:CAS:528:DC%2BD28XmvVajtLY%3D 10.1073/pnas.0603824103 16782807 (Pubitemid 43993597)
41. MB Herrera S Bruno S Buttiglieri C Tetta S Gatti MC Deregibus B Bussolati G Camussi 2006 Isolation and characterization of a stem cell population from adult human liver Stem Cells 24 2840 2850 1:CAS:528:DC%2BD2sXkslCrtg%3D%3D 10.1634/stemcells.2006-0114 16945998 (Pubitemid 46053020)
42. CA Lazaro EJ Croager C Mitchell JS Campbell C Yu J Foraker JA Rhim GC Yeoh N Fausto 2003 Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes Hepatology 38 1095 1106 10.1053/jhep.2003.50448 14578848 (Pubitemid 37314818)
43. ZF Yang DW Ho MN Ng CK Lau WC Yu P Ngai PW Chu CT Lam RT Poon ST Fan 2008 Significance of CD90+ cancer stem cells in human liver cancer Cancer Cell 13 153 166 1:CAS:528:DC%2BD1cXitFWrs7c%3D 10.1016/j.ccr.2008.01.013 18242515 (Pubitemid 351163165)
44. RJ Isfort DB Cody CJ Doersen WG Richards BK Yoder JE Wilkinson LD Kier RL Jirtle JS Isenberg JE Klounig RP Woychik 1997 The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene Oncogene 15 1797 1803 1:CAS:528:DyaK2sXmvVOrtL4%3D 10.1038/sj.onc.1201535 9362446
45. WG Richards BK Yoder RJ Isfort PG Detilleux C Foster N Neilsen RP Woychik JE Wilkinson 1997 Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice Am J Pathol 150 1189 1197 1:STN:280:DyaK2s3kvFSksg%3D%3D 9094975
46. WG Richards BK Yoder RJ Isfort PG Detilleux C Foster N Neilsen RP Woychik JE Wilkinson 1996 Oval cell proliferation associated with the murine insertional mutation TgN737Rpw Am J Pathol 149 1919 1930 1:CAS:528: DyaK2sXjtFOmsQ%3D%3D 8952527
47. JW Grisham WB Coleman GJ Smith 1993 Isolation, culture, and transplantation of rat hepatocytic precursor (stem-like) cells Proc Soc Exp Biol Med 204 270 279 1:CAS:528:DyaK2cXivVaiug%3D%3D 8234370
48. AE Sirica GA Mathis N Sano LW Elmore 1990 Isolation, culture, and transplantation of intrahepatic biliary epithelial cells and oval cells Pathobiology 58 44 64 1:STN:280:DyaK3c3ltlKjug%3D%3D 10.1159/000163564 2187478
49. A Alimov C Li R Gizatullin V Fredriksson B Sundelin G Klein E Zabarovsky U Bergerheim 1999 Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinoma Anticancer Res 19 3841 3846 1:CAS:528: DC%2BD3cXkt1Gq 10628321
50. M Gunduz M Ouchida K Fukushima H Hanafusa T Etani S Nishioka K Nishizaki K Shimizu 2000 Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas Cancer Res 60 3143 3146 1:CAS:528:DC%2BD3cXktlyktb8%3D 10866301
51. M Gunduz M Ouchida K Fukushima S Ito Y Jitsumori T Nakashima N Nagai K Nishizaki K Shimizu 2002 Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers Oncogene 21 4462 4470 1:CAS:528:DC%2BD38XkslKntL8%3D 10.1038/sj.onc.1205540 12080476 (Pubitemid 34774848)
52. BH Fu ZZ Wu J Qin 2010 Effects of integrins on laminin chemotaxis by hepatocellular carcinoma cells Mol Biol Rep 37 3 1665 1670 1:CAS:528: DC%2BC3cXhtlWqtLk%3D 10.1007/s11033-009-9790-1 19768654
53. Liu X, Liang J, Li G (2009) Lipopolysaccharide promotes adhesion and invasion of hepatoma cell lines HepG2 and HepG2.2.15. Mol Biol Rep. doi: 10.1007/s11033-009-9710-4
54. M Smalley A Ashworth 2003 Stem cells and breast cancer: a field in transit Nat Rev Cancer 3 832 844 1:CAS:528:DC%2BD3sXptFKlsL0%3D 10.1038/nrc1212 14668814
55. SK Singh ID Clarke M Terasaki VE Bonn C Hawkins J Squire PB Dirks 2003 Identification of a cancer stem cell in human brain tumors Cancer Res 63 5821 5828 1:CAS:528:DC%2BD3sXnvVSjtbc%3D 14522905
56. SG Zhang WQ Song YT Gao B Yang Z Du 2010 CD1d gene is a target for a novel amplicon at 1q22-23.1 in human hepatocellular carcinoma Mol Biol Rep 37 1 381 387 1:CAS:528:DC%2BC3cXisFSrtw%3D%3D 10.1007/s11033-009-9817-7 19757161
57. PE Grundy NE Breslow S Li E Perlman JB Beckwith ML Ritchey RC Shamberger GM Haase GJ D'Angio M Donaldson MJ Coppes M Malogolowkin P Shearer PR Thomas R Macklis G Tomlinson V Huff DM Green 2005 Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group J Clin Oncol 23 7312 7321 1:CAS:528:DC%2BD2MXhtF2nsLrN 10.1200/JCO.2005.01.2799 16129848 (Pubitemid 46205952)
58. CJ Marsit M Hasegawa T Hirao DH Kim K Aldape PW Hinds JK Wiencke HH Nelson KT Kelsey 2004 Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancer Cancer Res 64 8702 8707 1:CAS:528:DC%2BD2cXhtVCjs7rK 10.1158/0008-5472.CAN-04- 2558 15574780 (Pubitemid 39552086)
59. AV Tinker A Boussioutas DD Bowtell 2006 The challenges of gene expression microarrays for the study of human cancer Cancer Cell 9 333 339 1:CAS:528:DC%2BD28XltF2nsLw%3D 10.1016/j.ccr.2006.05.001 16697954 (Pubitemid 43668729)
60. O Morimoto H Nagano M Sakon Y Fujiwara T Yamada H Nakagawa A Miyamoto M Kondo I Arai T Yamamoto H Ota K Dono K Umeshita S Nakamori Y Sasaki O Ishikawa S Imaoka M Monden 2003 Diagnosis of intrahepatic metastasis and multicentric carcinogenesis by microsatellite loss of heterozygosity in patients with multiple and recurrent hepatocellular carcinomas J Hepatol 39 215 221 1:CAS:528:DC%2BD3sXlsVWlurc%3D 10.1016/S0168-8278(03)00233-2 12873818 (Pubitemid 36920557)
61. N Kusano K Okita H Shirahashi T Harada K Shiraishi A Oga S Kawauchi T Furuya K Sasaki 2002 Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma Cancer 94 746 751 10.1002/cncr.10254 11857308 (Pubitemid 34132304)
62. P Laurent-Puig P Legoix O Bluteau J Belghiti D Franco F Binot G Monges G Thomas P Bioulac-Sage J Zucman-Rossi 2001 Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis Gastroenterology 120 1763 1773 1:CAS:528:DC%2BD3MXkslGku7Y%3D 10.1053/gast.2001.24798 11375957
63. N Nishida Y Fukuda H Kokuryu T Sadamoto G Isowa K Honda Y Yamaoka M Ikenaga H Imura K Ishizaki 1992 Accumulation of allelic loss on arms of chromosomes 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma Int J Cancer 51 862 868 1:STN:280:DyaK38zkvVSnuw%3D%3D 10.1002/ijc.2910510605 1322376
64. P Saelee S Wongkham V Bhudhisawasdi B Sripa S Chariyalertsak S Petmitr 2008 Allelic loss on chromosome 5q34 is associated with poor prognosis in hepatocellular carcinoma J Cancer Res Clin Oncol 134 1135 1141 1:CAS:528:DC%2BD1cXhtVWktb7I 10.1007/s00432-008-0379-1 18386060
65. S Hertz T Rothamel B Skawran C Giere D Steinemann P Flemming T Becker J Flik B Wiese B Soudah H Kreipe B Schlegelberger L Wilkens 2008 Losses of chromosome arms 4q, 8p, 13q and gain of 8q are correlated with increasing chromosomal instability in hepatocellular carcinoma Pathobiology 75 312 322 10.1159/000151712 18931534
66. K Homayounfar B Gunawan S Cameron F Haller D Baumhoer S Uecker B Sander G Ramadori T Lorf L Fuzesi 2009 Pattern of chromosomal aberrations in primary liver cancers identified by comparative genomic hybridization Hum Pathol 40 834 842 1:CAS:528:DC%2BD1MXmtFekurk%3D 10.1016/j.humpath.2008.11.005 19200581
67. Y Midorikawa S Yamamoto S Ishikawa N Kamimura H Igarashi H Sugimura M Makuuchi H Aburatani 2006 Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays Oncogene 25 5581 5590 1:CAS:528:DC%2BD28XptFCmuro%3D 10.1038/sj.onc.1209537 16785998 (Pubitemid 44344109)
68. MA Patil I Gutgemann J Zhang C Ho ST Cheung D Ginzinger R Li KJ Dykema S So ST Fan S Kakar KA Furge R Buttner X Chen 2005 Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma Carcinogenesis 26 2050 2057 1:CAS:528:DC%2BD2MXht1ent7fE 10.1093/carcin/bgi178 16000397 (Pubitemid 41672192)
69. B Skawran D Steinemann T Becker R Buurman J Flik B Wiese P Flemming H Kreipe B Schlegelberger L Wilkens 2008 Loss of 13q is associated with genes involved in cell cycle and proliferation in dedifferentiated hepatocellular carcinoma Mod Pathol 21 1479 1489 1:CAS:528:DC%2BD1cXhsVSjsb3I 10.1038/modpathol.2008.147 18820673
70. CM Wong JM Lee TC Lau ST Fan IO Ng 2002 Clinicopathological significance of loss of heterozygosity on chromosome 13q in hepatocellular carcinoma Clin Cancer Res 8 2266 2272 1:CAS:528:DC%2BD38XmtVWhs7k%3D 12114430
71. D Steinemann B Skawran T Becker M Tauscher A Weigmann L Wingen S Tauscher T Hinrichsen S Hertz P Flemming J Flik B Wiese H Kreipe P Lichter B Schlegelberger L Wilkens 2006 Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization Clin Gastroenterol Hepatol 4 1283 1291 1:CAS:528:DC%2BD28Xht1Wms7zE 10.1016/j.cgh.2006.07.010 16979954 (Pubitemid 44512219)
72. YW Lin JC Sheu LY Liu CH Chen HS Lee GT Huang JT Wang PH Lee FJ Lu 1999 Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regions Eur J Cancer 35 1730 1734 1:STN:280:DC%2BD3c7jvV2ktA%3D%3D 10.1016/S0959-8049(99)00205-1 10674021 (Pubitemid 30050648)
73. C Bonura P Paterlini-Brechot C Brechot 1999 Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas Hepatology 30 677 681 1:CAS:528:DyaK1MXmtVSkt78%3D 10.1002/hep.510300325 10462374 (Pubitemid 29409412)