Mitochondria as integrators of signal transduction and energy production in cardiac physiology and disease

Journal of Molecular Medicine

Volumn 88, Issue 10, 2010, Pages 967-970

  Frohman, Michael A ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Fission; Fusion; Mitochondria; ROS; Signaling

Indexed keywords

REACTIVE OXYGEN METABOLITE;

CALCIUM HOMEOSTASIS; CELL PROLIFERATION; ENERGY YIELD; HEART DISEASE; HEART PROTECTION; HUMAN; ISCHEMIC HEART DISEASE; MITOCHONDRION; MUSCLE FIBRIL; NONHUMAN; OXIDATIVE STRESS; REVIEW; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

CARDIOVASCULAR DISEASES; ENERGY METABOLISM; HEART; MEMBRANE FUSION; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 78149410758     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0662-x     Document Type: Review

References (31)

1. V Soubannier HM McBride 2009 Positioning mitochondrial plasticity within cellular signaling cascades Biochim Biophys Acta 1793 154 170 1:CAS:528:DC%2BD1cXhsVWrtLzE 10.1016/j.bbamcr.2008.07.008 18694785
2. KG Hales MT Fuller 1997 Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase Cell 90 121 129 1:CAS:528:DyaK2sXkslSgsro%3D 10.1016/S0092-8674(00)80319-0 9230308 (Pubitemid 28009424)
3. J Wakabayashi Z Zhang N Wakabayashi Y Tamura M Fukaya TW Kensler M Iijima H Sesaki 2009 The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice J Cell Biol 186 805 816 1:CAS:528:DC%2BD1MXht1Srt7bJ 10.1083/jcb.200903065 19752021
4. H Ashrafian L Docherty V Leo C Towlson M Neilan V Steeples CA Lygate T Hough S Townsend D Williams S Wells D Norris S Glyn-Jones J Land I Barbaric Z Lalanne P Denny D Szumska S Bhattacharya JL Griffin I Hargreaves N Fernandez-Fuentes M Cheeseman H Watkins TN Dear 2010 A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy PLoS Genet 6 e1001000 10.1371/journal.pgen.1001000 20585624
5. DF Suen KL Norris RJ Youle 2008 Mitochondrial dynamics and apoptosis Genes Dev 22 1577 1590 1:CAS:528:DC%2BD1cXnvVWmsb4%3D 10.1101/gad.1658508 18559474 (Pubitemid 351846838)
6. A Tanaka RJ Youle 2008 A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis Mol Cell 29 409 410 1:CAS:528: DC%2BD1cXjtFCgsbw%3D 10.1016/j.molcel.2008.02.005 18313377 (Pubitemid 351282545)
7. S Campello RA Lacalle M Bettella S Manes L Scorrano A Viola 2006 Orchestration of lymphocyte chemotaxis by mitochondrial dynamics J Exp Med 203 2879 2886 1:CAS:528:DC%2BD2sXjsFaitA%3D%3D 10.1084/jem.20061877 17145957 (Pubitemid 46026165)
8. M Amiri PJ Hollenbeck 2008 Mitochondrial biogenesis in the axons of vertebrate peripheral neurons Dev Neurobiol 68 1348 1361 1:CAS:528: DC%2BD1cXhtFKlt7fP 10.1002/dneu.20668 18666204
9. H Chen SA Detmer AJ Ewald EE Griffin SE Fraser DC Chan 2003 Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development J Cell Biol 160 189 200 1:CAS:528:DC%2BD3sXntVamtQ%3D%3D 10.1083/jcb.200211046 12527753 (Pubitemid 36254953)
10. H Chen M Vermulst YE Wang A Chomyn TA Prolla JM McCaffery DC Chan 2010 Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations Cell 141 280 289 1:CAS:528:DC%2BC3cXmtVWnsLg%3D 10.1016/j.cell.2010.02.026 20403324
11. OM de Brito L Scorrano 2008 Mitofusin 2 tethers endoplasmic reticulum to mitochondria Nature 456 605 610 10.1038/nature07534 19052620
12. B Kornmann E Currie SR Collins M Schuldiner J Nunnari JS Weissman P Walter 2009 An ER-mitochondria tethering complex revealed by a synthetic biology screen Science 325 477 481 1:CAS:528:DC%2BD1MXovVCgt7c%3D 10.1126/science. 1175088 19556461
13. B Kornmann P Walter 2010 ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology J Cell Sci 123 1389 1393 1:CAS:528:DC%2BC3cXnt1Kmt7o%3D 10.1242/jcs.058636 20410371
14. KH Chen X Guo D Ma Y Guo Q Li D Yang P Li X Qiu S Wen RP Xiao J Tang 2004 Dysregulation of HSG triggers vascular proliferative disorders Nat Cell Biol 6 872 883 1:CAS:528:DC%2BD2cXntFCmsrg%3D 10.1038/ncb1161 15322553 (Pubitemid 39207252)
15. X Guo KH Chen Y Guo H Liao J Tang RP Xiao 2007 Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway Circ Res 101 1113 1122 1:CAS:528:DC%2BD2sXhtlahurjM 10.1161/CIRCRESAHA.107.157644 17901359 (Pubitemid 350146437)
16. MA Andrade-Navarro L Sanchez-Pulido HM McBride 2009 Mitochondrial vesicles: an ancient process providing new links to peroxisomes Curr Opin Cell Biol 21 560 567 1:CAS:528:DC%2BD1MXps1Cltbk%3D 10.1016/j.ceb.2009.04.005 19423315
17. M Neuspiel AC Schauss E Braschi R Zunino P Rippstein RA Rachubinski MA Andrade-Navarro HM McBride 2008 Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers Curr Biol 18 102 108 1:CAS:528:DC%2BD1cXot1GmtA%3D%3D 10.1016/j.cub.2007.12.038 18207745
18. X Liu D Weaver O Shirihai G Hajnoczky 2009 Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics EMBO J 28 3074 3089 1:CAS:528:DC%2BD1MXhtVygsLbJ 10.1038/emboj.2009.255 19745815
19. DP Narendra SM Jin A Tanaka DF Suen CA Gautier J Shen MR Cookson RJ Youle 2010 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin PLoS Biol 8 e1000298 10.1371/journal.pbio.1000298 20126261
20. H Yoshida T Matsui A Yamamoto T Okada K Mori 2001 XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor Cell 107 881 891 1:CAS:528:DC%2BD38XjtlKlsg%3D%3D 10.1016/S0092-8674(01)00611-0 11779464 (Pubitemid 34084979)
21. ZT Schug E Gottlieb 2009 Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis Biochim Biophys Acta 1788 2022 2031 1:CAS:528:DC%2BD1MXht1ais7fF 10.1016/j.bbamem.2009.05.004 19450542
22. M Lutter M Fang X Luo M Nishijima X Xie X Wang 2000 Cardiolipin provides specificity for targeting of tBid to mitochondria Nat Cell Biol 2 754 761 1:CAS:528:DC%2BD3cXnsVyntb4%3D 10.1038/35036395 11025668
23. SY Choi P Huang GM Jenkins DC Chan J Schiller MA Frohman 2006 A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis Nat Cell Biol 8 1255 1262 1:CAS:528:DC%2BD28XhtFCqu7jI 10.1038/ncb1487 17028579 (Pubitemid 44660590)
24. CF Cowell H Doppler IK Yan A Hausser Y Umezawa P Storz 2009 Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling J Cell Sci 122 919 928 1:CAS:528:DC%2BD1MXlt1Oqsbg%3D 10.1242/jcs.041061 19258390
25. SB Ong S Subrayan SY Lim DM Yellon SM Davidson DJ Hausenloy 2010 Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury Circulation 121 2012 2022 1:CAS:528:DC%2BC3cXlvVakurw%3D 10.1161/CIRCULATIONAHA.109.906610 20421521
26. K Reue JR Dwyer 2009 Lipin proteins and metabolic homeostasis J Lipid Res 50 Suppl S109 S114 10.1194/jlr.R800052-JLR200 18941140
27. FX Soriano M Liesa D Bach DC Chan M Palacin A Zorzano 2006 Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2 Diabetes 55 1783 1791 1:CAS:528:DC%2BD28XlsF2ru7o%3D 10.2337/db05-0509 16731843 (Pubitemid 44324133)
28. P Pawlikowska B Gajkowska A Orzechowski 2007 Mitofusin 2 (Mfn2): a key player in insulin-dependent myogenesis in vitro Cell Tissue Res 327 571 581 1:CAS:528:DC%2BD2sXhsV2jt7s%3D 10.1007/s00441-006-0320-3 17093923 (Pubitemid 46232326)
29. S Bonnet ED Michelakis CJ Porter MA Andrade-Navarro B Thebaud S Bonnet A Haromy G Harry R Moudgil MS McMurtry EK Weir SL Archer 2006 An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension Circulation 113 2630 2641 1:CAS:528:DC%2BD28XltFWgtbk%3D 10.1161/CIRCULATIONAHA.105.609008 16735674 (Pubitemid 43948012)
30. SL Archer G Marsboom GH Kim HJ Zhang PT Toth EC Svensson JR Dyck M Gomberg-Maitland B Thebaud AN Husain N Cipriani J Rehman 2010 Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension. A basis for excessive cell proliferation and a new therapeutic target Circulation 121 24 2661 2671 1:CAS:528:DC%2BC3cXnsl2hs74%3D 10.1161/CIRCULATIONAHA.109.916098 20529999
31. ED Michelakis MS McMurtry XC Wu JR Dyck R Moudgil TA Hopkins GD Lopaschuk L Puttagunta R Waite SL Archer 2002 Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels Circulation 105 244 250 1:CAS:528:DC%2BD38XhsFeksL0%3D 10.1161/hc0202.101974 11790708 (Pubitemid 34084326)