Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: Pharmacokinetic analysis and correlation to tumor histomorphology

Radiotherapy and Oncology

Volumn 97, Issue 2, 2010, Pages 217-224

  Ellingsen, Christine ^a   Egeland, Tormod A M ^a   Galappathi, Kanthi ^a   Rofstad, Einar K ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cervical carcinoma xenografts; Histomorphology; Magnetic resonance imaging

Indexed keywords

GADOLINIUM PENTETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONNECTIVE TISSUE; CONTRAST ENHANCEMENT; DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING; EXTRACELLULAR SPACE; FEMALE; HISTOPATHOLOGY; HUMAN; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARENCHYMA; PRIORITY JOURNAL; TISSUE NECROSIS; TUMOR XENOGRAFT; UTERINE CERVIX CARCINOMA;

ANIMALS; CONTRAST MEDIA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MICE, NUDE; TRANSPLANTATION, HETEROLOGOUS; UTERINE CERVICAL NEOPLASMS;

EID: 78149357777     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2010.06.011     Document Type: Article

References (28)

1. P.G. Rose, B.N. Bundy, and E.B. Watkins Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer N Engl J Med 340 1999 1144 1153
2. J.A. Green, J.M. Kirwan, and J.F. Tierney Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and metaanalysis Lancet 358 2001 781 786
3. A.W. Fyles, M. Milosevic, and R. Wong Oxygenation predicts radiation response and survival in patients with cervix cancer Radiother Oncol 48 1998 149 156 (Pubitemid 28423786)
4. K. Sundfør, H. Lyng, C.G. Tropé, and E.K. Rofstad Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization Radiother Oncol 54 2000 101 107
5. M.A. Zahra, K.G. Hollingsworth, and E. Sala Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy Lancet Oncol 8 2007 63 74
6. W.T.C. Yuh, N.A. Mayr, and D. Jarjoura Predicting control of primary tumor and survival by DCE MRI during early therapy in cervical cancer Invest Radiol 44 2009 343 350
7. Y. Yamashita, M. Takahashi, T. Sawada, T. Miyazaki, and H. Okamura Carcinoma of the cervix: dynamic MR imaging Radiology 182 1992 643 648
8. H. Hawighorst, P.G. Knapstein, and W. Weikel Angiogenesis of uterine cervical carcinoma: characterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement Cancer Res 57 1997 4777 4786
9. H. Hawighorst, W. Weikel, and P.G. Knapstein Angiogenic activity of cervical carcinoma: assessment by functional magnetic resonance imaging-based parameters and a histomorphological approach in correlation with disease outcome Clin Cancer Res 4 1998 2305 2312
10. Y. Yamashita, T. Baba, and Y. Baba Dynamic contrast-enhanced MR imaging of uterine cervical cancer: pharmacokinetic analysis with histopathologic correlation and its importance in predicting the outcome of radiation therapy Radiology 216 2000 803 809
11. R.A. Cooper, B.M. Carrington, and J.A. Loncaster Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix Radiother Oncol 57 2000 53 55
12. H. Lyng, A.O. Vorren, K. Sundfør, I. Taksdal, H.H. Lien, and E.K. Rofstad Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging J Magn Reson Imaging 14 2001 750 756
13. M.A. Zahra, L.T. Tan, and A.N. Priest Semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging measurements predict radiation response in cervix cancer Int J Radiat Oncol Biol Phys 74 2009 766 773
14. S.I.K. Semple, V.N. Harry, D.E. Parkin, and F.J. Gilbert A combined pharmacokinetic and radiologic assessment of dynamic contrast-enhanced magnetic resonance imaging predicts response to chemoradiation in locally advanced cervical cancer Int J Radiat Oncol Biol Phys 75 2009 611 617
15. C. Ellingsen, I. Natvig, J.V. Gaustad, K. Gulliksrud, T.A.M. Egeland, and E.K. Rofstad Human cervical carcinoma xenograft models for studies of the physiological microenvironment of tumors J Cancer Res Clin Oncol 135 2009 1177 1184
16. C. Ellingsen, T.A.M. Egeland, K. Gulliksrud, J.V. Gaustad, B. Mathiesen, and E.K. Rofstad Assessment of hypoxia in human cervical carcinoma xenografts by dynamic contrast-enhanced magnetic resonance imaging Int J Radiat Oncol Biol Phys 73 2009 838 845
17. I.K. Vestvik, T.A.M. Egeland, J.V. Gaustad, B. Mathiesen, and E.K. Rofstad Assessment of microvascular density, extracellular volume fraction, and radiobiological hypoxia in human melanoma xenografts by dynamic contrast-enhanced MRI J Magn Reson Imaging 26 2007 1033 1042
18. K. Hittmair, G. Gomiscek, and K. Langenberger Method for the quantitative assessment of contrast agent uptake in dynamic contrast-enhanced MRI Magn Reson Med 31 1994 567 571
19. I.C. Benjaminsen, B.A. Graff, K.G. Brurberg, and E.K. Rofstad Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced MRI: a preclinical study of human melanoma xenografts Magn Reson Med 52 2004 269 276
20. 1-weighted MRI of a diffusible tracer: standardized quantities and symbols J Magn Reson Imaging 10 1999 223 232
21. T.A.M. Egeland, T.G. Simonsen, J.V. Gaustad, K. Gulliksrud, C. Ellingsen, and E.K. Rofstad Dynamic contrast-enhanced magnetic resonance imaging of tumors: preclinical validation of parametric images Radiat Res 172 2009 339 347
22. E.K. Rofstad, and E.F. Halsør Vascular endothelial growth factor, interleukin-8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts Cancer Res 60 2000 4932 4938
23. J.V. Gaustad, I.C. Benjaminsen, E.B.M. Ruud, and E.K. Rofstad Dynamic contrast-enhanced magnetic resonance imaging of human melanoma xenografts with necrotic regions J Magn Reson Imaging 26 2007 133 143
24. T.A.M. Egeland, J.V. Gaustad, I.K. Vestvik, I.C. Benjaminsen, B. Mathiesen, and E.K. Rofstad Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI Magn Reson Med 55 2006 874 882
25. T.A.M. Egeland, J.V. Gaustad, I.C. Benjaminsen, K. Hedalen, B. Mathiesen, and E.K. Rofstad Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI Radiat Res 169 2008 689 699
26. K. Gulliksrud, K.G. Brurberg, and E.K. Rofstad Dynamic contrast-enhanced magnetic resonance imaging of tumor interstitial fluid pressure Radiother Oncol 91 2009 107 113
27. K.G. Brurberg, I.C. Benjaminsen, L.M.R. Dørum, and E.K. Rofstad Fluctuations in tumor blood perfusion assessed by dynamic-contrast enhanced MRI Magn Reson Med 58 2007 473 481
28. I.C. Benjaminsen, E.A. Mels, B.S. Mathiesen, and E.K. Rofstad Limitations of dynamic contrast-enhanced MRI in monitoring radiation-induced changes in the fraction of radiobiologically hypoxic cells in human melanoma xenografts J Magn Reson Imaging 28 2008 1209 1218