Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI

Radiation Research

Volumn 169, Issue 6, 2008, Pages 689-699

  Egeland, Tormod A M ^a   Gaustad, Jon Vidar ^a   Benjaminsen, Ilana C ^a   Hedalen, Kristin ^a   Mathiesen, Berit ^a   Rofstad, Einar K ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GADOLINIUM PENTETATE MEGLUMINE;

ANIMAL EXPERIMENT; ARTICLE; CELL FRACTIONATION; CELL HYPOXIA; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE PROCESSING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TISSUE NECROSIS; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR XENOGRAFT;

ANIMALS; ANOXIA; CELL LINE, TUMOR; CONTRAST MEDIA; FEMALE; GADOLINIUM DTPA; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MICE, NUDE; NECROSIS; NEOPLASM TRANSPLANTATION; TIME FACTORS;

EID: 44849115685     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1311.1     Document Type: Article

References (38)

1. R. K. Jain, Determinants of tumor blood flow: a review. Cancer Res. 48, 2641-2658 (1988).
2. P. Vaupel, F. Kallinowski and P. Okunieff, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 49, 6449-6465 (1989).
3. G. G. Steel, Growth Kinetics of Tumours. Clarendon Press, Oxford, 1977.
4. H. Lyng, O. Haraldseth and E. K. Rofstad, Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging. Magn. Reson. Med. 43, 828-836 (2000).
5. J. Bussink, J. H. Kaanders and A. J. van der Kogel, Tumor hypoxia at the microregional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother. Oncol. 67, 3-15 (2003).
6. A. S. E. Ljungkvist, J. Bussink, P. F. J. W. Rijken, J. H. A. M. Kaanders, A. J. van der Kogel and J. Denekamp, Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 54, 215-228 (2002).
7. A. S. E. Ljungkvist, J. Bussink, J. H. A. M. Kaanders and A. J. van der Kogel, Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat. Res. 167, 127-145 (2007).
8. M. Höckel and P. Vaupel, Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93, 266-276 (2001).
9. E. K. Rofstad, H. Rasmussen, K. Galappathi, B. Mathiesen, K. Nilsen and B. A. Graff, Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res. 62, 1847-1853 (2002).
10. R. A. Cairns and R. P. Hill, Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Res. 64, 2054-2061 (2004).
11. E. K. Rofstad, K. Sundfør, H. Lyng and C. G. Tropé, Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br. J. Cancer 83, 354-359 (2000).
12. D. M. Brizel, R. K. Dodge, R. W. Clough and M. W. Dewhirst, Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother. Oncol. 53, 113-117 (1999).
13. M. Nordsmark, J. Alsner, J. Keller, O. S. Nielsen, O. M. Jensen, M. R. Horsman and J. Overgaard, Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br. J. Cancer 84, 1070-1075 (2001).
14. A. R. Padhani, Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions. J. Magn. Reson. Imaging 16, 407-422 (2002).
15. P. S. Tofts, G. Brix, D. L. Buckley, J. L. Evelhoch, E. Henderson, M. V. Knopp, H. B. W. Larsson, T-Y. Lee, N. A. Mayr and R. M. Weisskoff, Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J. Magn. Reson. Imaging 10, 223-232 (1999).
16. H. Lyng, A. O. Vorren, K. Sundfør, I. Taksdal, H. H. Lien, O. Kaalhus and E. K. Rofstad, Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging. J. Magn. Reson. Imaging 14, 750-756 (2001).
17. A. F. de Vries, C. Kremser, P. A. Hein, J. Griebel, A. Krezcy, D. Öfner, K-P. Pfeiffer, P. Lukas and W. Judmaier, Tumor microcirculation and diffusion predict therapy outcome for primary rectal carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 56, 958-965 (2003).
18. R. A. Cooper, B. M. Carrington, J. A. Loncaster, S. M. Todd, S. E. Davidson, J. P. Logue, A. D. Luthra, A. P. Jones, I. Stratford and C. M. L. West, Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix. Radiother. Oncol. 57, 53-59 (2000).
19. J. A. Loncaster, B. M. Carrington, J. R. Sykes, A. P. Jones, S. M. Todd, R. Cooper, D. L. Buckley, S. E. Davidson, J. P. Logue and C. M. L. West, Prediction of radiotherapy outcome using dynamic contrast enhanced MRI of carcinoma of the cervix. Int. J. Radiat. Oncol. Biol. Phys. 54, 759-767 (2002).
20. I. C. Benjaminsen, B. A. Graff, K. G. Brurberg and E. K. Rofstad, Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced MRI: a preclinical study of human melanoma xenografts. Magn. Reson. Med. 52, 269-276 (2004).
21. I. C. Benjaminsen, K. G. Brurberg, E. B. M. Ruud and E. K. Rofstad, Assessment of extravascular extracellular space fraction in human melanoma xenografts by DCE-MRI and kinetic modeling. Magn. Reson. Imaging 26, 160-170 (2008).
22. T. A. M. Egeland, J. V. Gaustad, I. K. Vestvik, I. C. Benjaminsen, B. Mathiesen and E. K. Rofstad, Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI. Magn. Reson. Med. 55, 874-882 (2006).
23. I. K. Vestvik, T. A. M. Egeland, J. V. Gaustad, B. Mathiesen and E. K. Rofstad, Assessment of microvascular density, extracellular volume fraction, and radiobiological hypoxia in human melanoma xenografts by dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging 26, 1033-1042 (2007).
24. J. V. Gaustad, I. C. Benjaminsen, E. B. M. Ruud and E. K. Rofstad, Dynamic contrast-enhanced magnetic resonance imaging of human melanoma xenografts with necrotic regions. J. Magn. Reson. Imaging 26, 133-143 (2007).
25. E. K. Rofstad, Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern. Br. J. Cancer 70, 804-812 (1994).
26. E. K. Rofstad, E. Steinsland, O. Kaalhus, Y. B. Chang, B. Høvik and H. Lyng, Magnetic resonance imaging of human melanoma xenografts in vivo: proton spin-lattice and spin-spin relaxation times versus fractional tumour water content and fraction of necrotic tumour tissue. Int. J. Radiat. Biol. 65, 387-401 (1994).
27. K. Hittmair, G. Gomiscek, K. Langenberger, M. Recht, H. Imhof and J. Kramer, Method for the quantitative assessment of contrast agent uptake in dynamic contrast-enhanced MRI. Magn. Reson. Med. 31, 567-571 (1994).
28. S. Kety, Theory of blood-tissue exchange and its application to measurements of blood flow. Methods Med. Res. 8, 228-236 (1960).
29. E. J. Hall, Radiobiology for the Radiologist, 5th ed. Lippincott Williams & Wilkins, Philadelphia, 2000.
30. E. K. Rofstad, K. Henriksen, K. Galappathi and B. Mathiesen, Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts. Cancer Res. 63, 4055-4061 (2003).
31. E. K. Rofstad and K. Måseide, Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours. Int. J. Radiat. Biol. 75, 1377-1393 (1999).
32. H. B. Stone, J. M. Brown, T. L. Phillips and R. M. Sutherland, Oxygen in human tumors: correlations between methods of measurement and response to therapy. Radiat. Res. 136, 422-434 (1993).
33. B. M. Fenton, M. F. Kiani and D. W. Siemann, Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor? Int. J. Radiat. Oncol. Biol. Phys. 33, 365-373 (1995).
34. B. A. Graff, I. C. Benjaminsen, K. G. Brurberg, E. B. M. Ruud and E. K. Rofstad, Comparison of tumor blood perfusion assessed by dynamic contrast-enhanced MRI with tumor blood supply assessed by invasive imaging. J. Magn. Reson. Imaging 21, 272-281 (2005).
35. P. M. Gullino, Extracellular compartments of solid tumors. In Cancer, Vol. 3 (F. F. Becker, Ed.), pp. 327-354. Plenum Press, New York, 1975.
36. I. Tufto and E. K. Rofstad, Interstitial fluid pressure, fraction of necrotic tumor tissue, and tumor cell density in human melanoma xenografts. Acta Oncol. 37, 291-297 (1998).
37. I. Tufto, H. Lyng and E. K. Rofstad, Vascular density in human melanoma xenografts: relationship to angiogenesis, perfusion and necrosis. Cancer Lett. 123, 159-165 (1998).
38. C. J. Gulledge and M. W. Dewhirst, Tumor oxygenation: a matter of supply and demand. Anticancer Res. 16, 741-750 (1996).