HIV-1 activates proinflammatory and interferon-inducible genes in human brain microvascular endothelial cells: Putative mechanisms of blood-brain barrier dysfunction

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 4, 2008, Pages 697-711

  Chaudhuri, Anathbandhu ^a   Duan, Fenghai ^b   Morsey, Brenda ^a   Persidsky, Yuri ^a   Kanmogne, Georgette D ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Blood brain barrier; Cell signaling; HIV 1; Inflammation; Injury; Monocyte derived macrophages

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; BETA ARRESTIN 1; CHEMOKINE; CYTOKINE; ESTRADIOL 3 METHYL ETHER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; SN 50; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN RECEPTOR 2;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENDOTHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN; CELL MOVEMENT; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; INFLAMMATION; INTERFERONS; MACROPHAGES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 41149126024     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600567     Document Type: Article

References (40)

1. Alexander SP, Mathie A, Peters JA (2007) 7TM receptors. Br J Pharmacol 150(Suppl 1):S4-81
2. Avison MJ, Nath A, Greene-Avison R, Schmitt FA, Bales RA, Ethisham A, Greenberg RN, Berger JR (2004) Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia. J Neurovirol 10:223-32
3. Baca LM, Genis P, Kalvakolanu D, Sen G, Meltzer MS, Zhou A, Silverman R, Gendelman HE (1994) Regulation of interferon-alpha-inducible cellular genes in human immunodeficiency virus-infected monocytes. J Leukoc Biol 55:299-309
4. Boven LA, Middel J, Breij EC, Schotte D, Verhoef J, Soderland C, Nottet HS (2000) Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines. J Neurovirol 6:382-9
5. Burger DM, Boucher CA, Meenhorst PL, Kraayeveld CL, Portegies P, Mulder JW, Hoetelmans RM, Beijnen JH (1997) HIV-1 RNA levels in the cerebrospinal fluid may increase owing to damage to the blood-brain barrier. Antivir Ther 2:113-7
6. Couraud PO (1998) Infiltration of inflammatory cells through brain endothelium. Pathol Biol (Paris) 46:176-80
7. Cucullo L, Hossain M, Rapp E, Manders T, Marchi N, Janigro D (2007) Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. Epilepsia 48:505-16
8. D'Isanto M, Vitiello M, Raieta K, Galdiero M, Galdiero M (2004) Prolactin modulates IL-8 production induced by porins or LPS through different signaling mechanisms. Immunobiology 209:523-33
9. Dallasta LM, Pisarov LA, Esplen JE, Werley JV, Moses AV, Nelson JA, Achim CL (1999) Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am J Pathol 155:1915-27
10. Eisen MB, Spellman PT, Brown PO, Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-8
11. Flora G, Pu H, Hennig B, Toborek M (2006) Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain. Neuromolecular Med 8:337-52
12. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5:R80
13. Greenwood J, Etienne-Manneville S, Adamson P, Couraud PO (2002) Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier. Vascul Pharmacol 38:315-22
14. Haorah J, Ramirez SH, Schall K, Smith D, Pandya R, Persidsky Y (2007) Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J Neurochem 101:566-76
15. Hawkins BT, Davis TP (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57:173-85
16. Hillyer P, Mordelet E, Flynn G, D (2003) Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue-specific functions that affect leucocyte migration. Clin Exp Immunol 134:431-41
17. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:e15
18. Kanmogne GD, Primeaux C, Grammas P (2005) HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia. J Neuropathol Exp Neurol 64:498-505
19. Kanmogne GD, Schall K, Leibhart J, Knipe B, Gendelman HE, Persidsky Y (2007) HIV-1 gp120 compromises blood-brain barrier integrity and enhances monocyte migration across blood-brain barrier: implication for viral neuropathogenesis. J Cereb Blood Flow Metab 27:123-34
20. Kedzierska K, Crowe SM (2001) Cytokines and HIV-1: interactions and clinical implications. Antivir Chem Chemother 12:133-50
21. Laverda AM, Gallo P, De Rossi A, Sivieri S, Cogo P, Pagliaro A, Chieco-Bianchi L, Tavolato B (1994) Cerebrospinal fluid analysis in HIV-1-infected children: immunological and virological findings before and after AZT therapy. Acta Paediatr 83:1038-42
22. Masliah E, DeTeresa RM, Mallory ME, Hansen LA (2000) Changes in pathological findings at autopsy in AIDS cases for the last 15 years. Aids 14:69-74
23. Masliah E, Roberts ES, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox HS (2004) Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. J Neuroimmunol 157:163-75
24. Maslin CL, Kedzierska K, Webster NL, Muller WA, Crowe SM (2005) Transendothelial migration of monocytes: the underlying molecular mechanisms and consequences of HIV-1 infection. Curr HIV Res 3:303-17
25. Murdoch C, Monk PN, Finn A (1999) Cxc chemokine receptor expression on human endothelial cells. Cytokine 11:704-12
26. Otani T, Yamaguchi K, Scherl E, Du B, Tai HH, Greifer M, Petrovic L, Daikoku T, Dey SK, Subbaramaiah K, Dannenberg AJ (2006) Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha. Am J Physiol Gastrointest Liver Physiol 290:G361-8
27. Pereira CF, Boven LA, Middel J, Verhoef J, Nottet HS (2000) Induction of cyclooxygenase-2 expression during HIV-1-infected monocyte-derived macrophage and human brain microvascular endothelial cell interactions. J Leukoc Biol 68:423-8
28. Perrella O, Carrieri PB, Guarnaccia D, Soscia M (1992) Cerebrospinal fluid cytokines in AIDS dementia complex. J Neurol 239:387-8
29. Persidsky Y, Zheng J, Miller D, Gendelman HE (2000) Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia. J Leukoc Biol 68:413-22
30. Poluektova L, Moran T, Zelivyanskaya M, Swindells S, Gendelman HE, Persidsky Y (2001) The regulation of alpha chemokines during HIV-1 infection and leukocyte activation: relevance for HIV-1-associated dementia. J Neuroimmunol 120:112-28
31. Pu H, Tian J, Flora G, Lee YW, Nath A, Hennig B, Toborek M (2003) HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol Cell Neurosci 24:224-37
32. Reutershan J (2006) CXCR2 - the receptor to hit? Drug News Perspect 19:615-23
33. Ricardo-Dukelow M, Kadiu I, Rozek W, Schlautman J, Persidsky Y, Ciborowski P, Kanmogne GD, Gendelman HE (2007) HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia. J Neuroimmunol 185:37-46
34. Seguin R, Biernacki K, Rotondo RL, Prat A, Antel JP (2003) Regulation and functional effects of monocyte migration across human brain-derived endothelial cells. J Neuropathol Exp Neurol 62:412-9
35. Siddharthan V, Kim YV, Liu S, Kim KS (2007) Human astrocytes/astrocyte- conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells. Brain Res 1147:39-50
36. Smyth GK (2004) Linear models and empirical Bayes methods for assessing differential expression in micro-array experiments. Stat Appl Genet Mol Biol 3:Article3
37. Tang SC, Leung JC, Chan LY, Tsang AW, Lai KN (2006) Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist. J Am Soc Nephrol 17:1633-43
38. Tong M, Ding Y, Tai HH (2006) Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. Carcinogenesis 27:2170-9
39. Witt PL, Spear GT, Lindstrom MJ, Kessler HA, Borden EC, Phair J, Landay AL (1991) 2′,5′-oligoadenylate synthetase, neopterin and beta 2-microglobulin in asymptomatic HIV-infected individuals. Aids 5:289-93
40. Wu Z, Irizarry RA, Gentleman R, Martinez-Murillo F, Spencer F (2004) A model-based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 99:909-17