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1
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35548988646
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Safety and antiviral activity of the novel CCR5 Antagonist Aplaviroc in combination with Zidovudin + Lamivudine in HIV-Infected Therapy-naïve Subjects
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November 12-16, Glasgow, United Kingdom. Abstract P392
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Currier J, Lazzarin A, Kleim J-P, Steel H, Millard J, Bonny T, et al. 2006. Safety and antiviral activity of the novel CCR5 Antagonist Aplaviroc in combination with Zidovudin + Lamivudine in HIV-Infected Therapy-naïve Subjects, 8th International Congress on Drug Therapy in HIV; November 12-16, 2006; Glasgow, United Kingdom. Abstract P392.
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(2006)
8th International Congress on Drug Therapy in HIV
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Currier, J.1
Lazzarin, A.2
Kleim, J.-P.3
Steel, H.4
Millard, J.5
Bonny, T.6
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2
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33644658900
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Challenges of developing R5 inhibitors in antiretroviral naive HTV-infected patients
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Deeks SG. Challenges of developing R5 inhibitors in antiretroviral naive HTV-infected patients. Lancet 2006;367: 711-713.
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Lancet
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Deeks, S.G.1
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3
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30744447460
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Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
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Fatkenheuer G, Pozniak AL, Johnson MA, et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med. 2005;11:1170-1172.
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Fatkenheuer, G.1
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35549007405
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Greaves W, Landovitz R, Fatkenheuer G, et al. Late virologic breakthrough in treatment-naïve patients on a regimen of Combivir + vicriviroc. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections; February 5-8, 2006; Denver, Colorado. Abstract 161LB.
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Greaves W, Landovitz R, Fatkenheuer G, et al. Late virologic breakthrough in treatment-naïve patients on a regimen of Combivir + vicriviroc. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections; February 5-8, 2006; Denver, Colorado. Abstract 161LB.
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5
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35549011254
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Gulick R et al. ACTG 5211: phase II study of the safety and efficacy of vicriviroc (VCV) in HIV + treatment-experienced subjects: 48-week results. Program and abstracts of the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract TUAB102
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Gulick R et al. ACTG 5211: phase II study of the safety and efficacy of vicriviroc (VCV) in HIV + treatment-experienced subjects: 48-week results. Program and abstracts of the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract TUAB102
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6
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34347379935
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Gulick RM, Su Z, Flexner C et al. and others (for the AIDS Clinical Trials Group 5211 Team). Phase 2 Study of the Safety and Efficacy of Vicriviroc, a CCR5 Inhibitor, in HIV-1-Infected, Treatment-Experienced Patients: AIDS Clinical Trials Group 5211. Journal of Infectious Diseases 196(2): 304-312. July 15, 2007.
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Gulick RM, Su Z, Flexner C et al. and others (for the AIDS Clinical Trials Group 5211 Team). Phase 2 Study of the Safety and Efficacy of Vicriviroc, a CCR5 Inhibitor, in HIV-1-Infected, Treatment-Experienced Patients: AIDS Clinical Trials Group 5211. Journal of Infectious Diseases 196(2): 304-312. July 15, 2007.
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7
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33749039498
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Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia
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Hunt PW, Harrigan PR, Huang W, et al. Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia. J Infect Dis 2006; 194:926-930.
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Hunt, P.W.1
Harrigan, P.R.2
Huang, W.3
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8
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68949127140
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Virologic characterization of treatment naive subjects failing an aplaviroc-based regimen with either lamivudine/zidovudine or lopinavir/ ritonavir
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June 13-17, Sitges, Spain. Abstract 21
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Kitrinos, KM, Irlbeck, DM, LaBranche, CC, Madsen, HA, and Demarest, JF. 2006. Virologic characterization of treatment naive subjects failing an aplaviroc-based regimen with either lamivudine/zidovudine or lopinavir/ ritonavir. XV International Drug Resistance Workshop; June 13-17, 2006; Sitges, Spain. Abstract 21
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(2006)
XV International Drug Resistance Workshop
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Kitrinos, K.M.1
Irlbeck, D.M.2
LaBranche, C.C.3
Madsen, H.A.4
Demarest, J.F.5
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9
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25844450042
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Antiviral activity and safety of 873140, a novel CCR5 Antagonist, during short term monotherapy in HIV-infected adults
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Lalezari J, Thomson M, Kumar P et al. Antiviral activity and safety of 873140, a novel CCR5 Antagonist, during short term monotherapy in HIV-infected adults. AIDS 2005; 19:1443-8
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AIDS
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Lalezari, J.1
Thomson, M.2
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10
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35549006569
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Mayer H, van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experiences subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial. XVI International AIDS Conference. August 13-18, 2006. Toronto. Abstract THLB0215
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Mayer H, van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experiences subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial. XVI International AIDS Conference. August 13-18, 2006. Toronto. Abstract THLB0215
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11
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14844333093
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Epidemiology and Predictive Factors for Chemokine Receptor Use in HIV-1 Infection
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Moyle G, Wildfire A, Mandalia S, Mayer H, Goodrich J, Whitcomb J, Gazzard BG: Epidemiology and Predictive Factors for Chemokine Receptor Use in HIV-1 Infection, The Journal of Infectious Diseases, volume 191 (2005), pages 866-872
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The Journal of Infectious Diseases
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Moyle, G.1
Wildfire, A.2
Mandalia, S.3
Mayer, H.4
Goodrich, J.5
Whitcomb, J.6
Gazzard, B.G.7
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12
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35549012602
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Nichols WG, Steel HM, Bonny TM, Min SS, Curtis L, Kabeya K, Clumeck N. Hepatotoxicity observed in clinical trials of aplaviroc (APL, 873140). Special Oral Communication, 2005 EACS, Dublin, Ireland.
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Nichols WG, Steel HM, Bonny TM, Min SS, Curtis L, Kabeya K, Clumeck N. Hepatotoxicity observed in clinical trials of aplaviroc (APL, 873140). Special Oral Communication, 2005 EACS, Dublin, Ireland.
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13
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35549013532
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Full Prescribing Information, August
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Pfizer, Selzenrty, Full Prescribing Information, August 2007. http://media.pfizer.com/files/products/uspi_maraviroc.pdf
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Selzenrty
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14
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33644820755
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Trials of aplaviroc halted in treatment-naive patients
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November
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Ryan CT. Trials of aplaviroc halted in treatment-naive patients. AIDS Clin Care. November 2005;17(11):107-108
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Ryan, C.T.1
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15
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35548991237
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A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, maravsroc vs efavirenz, both in combination with Combivir for the treatment of antiretroviral naive patients infected with R5 HIV 1: Week 48 results of the MERIT study
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Saag M, Ive P, Heera J, et al. A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, maravsroc vs efavirenz, both in combination with Combivir for the treatment of antiretroviral naive patients infected with R5 HIV 1: week 48 results of the MERIT study. 4th International AIDS Society conference; July 22-25, 2007; Sydney, Australia. WESS104
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4th International AIDS Society conference; July 22-25, 2007; Sydney, Australia. WESS104
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Saag, M.1
Ive, P.2
Heera, J.3
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16
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34250006524
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Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults
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June
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Schurmann D; Fatkenheuer G; Reynes J; Michelet C, et al. Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults. AIDS. 21(10):1293-1299, June 2007.
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Schurmann, D.1
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35548956213
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Shepherd J, Jacobson L, Qiao W, et al. Analysis of the timing of CXCR4-tropic HIV emergence in the MACS cohort. XVI International AIDS Conference. August 13-18, 2006. Toronto. Abstract TUPE0001.
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Shepherd J, Jacobson L, Qiao W, et al. Analysis of the timing of CXCR4-tropic HIV emergence in the MACS cohort. XVI International AIDS Conference. August 13-18, 2006. Toronto. Abstract TUPE0001.
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18
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70349466282
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Safety and Antiviral activity of the novel CCR5 Anttagonist Aplaviroc in Combination with Lopinavir/itonavir in HIV Infected Thearpy naïve subjects
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November 12-16, Glasgow United Kingdom. Abstract P394
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Yeni P, Rockstroh J, LaMarca A, Madison S, Nichols G, et al. Safety and Antiviral activity of the novel CCR5 Anttagonist Aplaviroc in Combination with Lopinavir/itonavir in HIV Infected Thearpy naïve subjects. 8th International Congress on Drug Therapy in HIV; November 12-16, 2006; Glasgow United Kingdom. Abstract P394.
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8th International Congress on Drug Therapy in HIV
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Yeni, P.1
Rockstroh, J.2
LaMarca, A.3
Madison, S.4
Nichols, G.5
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