Synthesis and antibacterial activity of thioureido amide of fluoroquinolone

International Journal of Biological Chemistry

Volumn 5, Issue 1, 2011, Pages 37-45

  Patel, N B ^a   Patel, S D ^a   Patel, J N ^a   Patel, J C ^a   Gorgamwala, Y S ^a  

^a VEER NARMAD SOUTH GUJARAT UNIVERSITY   (India)

Author keywords

Ciprofloxacin; Cup plate method; Piperazine; Significant activity

Indexed keywords

BACILLUS SUBTILIS; ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 78149331032     PISSN: 1819155X     EISSN: None     Source Type: Journal    
DOI: 10.3923/ijbc.2011.37.45     Document Type: Article

References (22)

1. Bhanot, S.K., M. Singh and N.R. Chatterjee, 2001. The chemical and biological aspects of fluoroquinolone: Reality and dreams. Curr. Pharma. Design, 7: 313-335.
2. Clikla, P., G. Kucukguzel, I. Kucukguzel, S. Rollas and E. Clercq et al., 2010. Synthesis and evaluation of antiviral, antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones. Marmara Pharma. J., 14: 13-20.
3. Collee, G.J., G.A. Fraser, P.B. Marmion and A. Simmon, 1996. Practical Medical Microbiology. 14th Edn., Churcill Livinstone, Edinburg, pp: 163-174.
4. Edmont, D., R. Rocher, C. Plisson and J. Chenault, 2000. Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents. Bioorg. Med. Chem. Lett., 10: 1831-1834.
5. Emani, S., A. Shafiee and A. Foroumadi, 2005. Quinolones: Recent structural and clinical developments. Iranian. J. Pharma. Res., 3: 123-136.
6. Figueiredo, I.M., V. Luciane, F. Willian, J. Carvalho and C.C. Silva et al., 2006. Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety. J. Braz. Chem. Soc., 17: 954-960.
7. Lucero, B., C. Regina, I. Frugulhetti, L. Alvarenga, M. de Souza, T. de Souzab and V. Ferreira, 2006. Synthesis and anti-HSV-1 activity of quinolonic acyclovir analogues. Bioorg. Med. Chem. Lett., 16: 1010-1013.
8. Maruyama, T., N. Seki, K. Onda, T. Suzuki and S. Kawazoe et al., 2009. Discovery of novel thiourea derivatives as potent and selective β3-adrenergic receptor agonists. Bio. Org. Med. Chem., 17: 5510-5519.
9. Mitscher, L.A., 2005. Topoisomerase inhibitors: Quinolone and Pyridone antibacterial agents. Chem. Rev., 105: 559-592.
10. Patel, N.B. and P. Bhagat, 2006. Synthesis and antimicrobial studies on fluoroquinolone with sulfonamides at C-3 and 4-(p-nitrobenzoyl)piperazine at C-7 position. Indian J. Heterocyl Chem., 16:205-221.
11. Patel, N.B., A.L. Patel and H.I. Chauhan, 2007. Synthesis of amide derivatives of quinolone and their antimicrobial studies. Ind. J. Chem., 46: 126-134.
12. Patel, N.B. and S.D. Patel, 2009. Synthesis and antimicrobial activity of 2-phenyl-3-{l-cyclopropyl-6-fluoro-7-[4-methylpiperazin-l-yl]-4-quinolone}carboxamido-3-thiazolidin-4-ones. Pharma. Chem. J., 43: 305-310.
13. Patel, N.B. and S.D. Patel, 2010. Synthesis and in vitro antimicrobial study of schiff base and thiazolidinone of l-cyclopropyl-6-fluoro-7-[4-(2,3-dichlorophenyl)piperazin-l-yl]-4-quinolone. Acta Pol. Pharma. Drug Res., 67: 45-53.
14. Ravichandran, V, V.K. Mourya and R.K. Agrawal, 2009. Prediction of anti-hiv activity of phenyl ethyl thiourea (pet) derivatives: QSAR approach. Digest J. Nano. Biostruct., 4: 213-221.
15. Shaharyar, M, M.A. Ali and M.M. Abdullah, 2007. Synthesis and antiproliferative activity of 1-[(sub)]-6-fluoro-3-[(sub)]-l,3,4-oxadiazol-2-yl-7-piperazino-l,4-dihydro-4-quinolinone derivatives. Med. Chem. Res., 16: 292-299.
16. Sharma, P.C. and S. Jain, 2008. Synthesis and in vitro antibacterial activity of some novel n-nicotinoyl-l-ethyl-6-fluoro-l,4-dihydro-7-piperazin-l-yl-4-oxoquinoline-3-carboxylates. Acta Pol. Pharma., 65: 551-556.
17. Sharma, P.C., A. Jain and S. Jain, 2009. Fluoroquinolone antibacterials: A review on chemistry, microbiology and therapeutic prospects. Acta Pol. Pharma. Drug Res., 66: 587-604.
18. Srivastava, S.K., P. Chauhan, A.P. Bhaduri, N. Fatima and R.K. Chatterjee, 2000. Quinolones: Novel probes in antifilarial chemotheraphy. J. Med. Chem., 43: 2275-2279.
19. Tabarrini, O, S. Massari, D. Daelemans, M. Stevens and G. Manfroni et al., 2008. Structure activity relationship study on anti-HIV 6-desfluoroquinolones. J. Med. Chem., 51: 5454-5458.
20. Turan-Zitouni, G, D.M. Sivaci, Z.A. Kaplancikli and A. Ozdemir, 2002. Synthesis and antimicrobial activity of some pyridinyliminothiazoline derivatives. Farmaco, 57: 569-572.
21. Venkatesh, P. and S.N. Pandeya, 2009. Synthesis, characterisation and anti-inflammatory activity of some 2-amino benzothiazole derivatives. Int. J. Chemtech Res., 1: 1354-1358.
22. Yan, Z, X. Cai, X. Yang, B. Song and Z. Chen et al., 2009. Synthesis and antiviral activities of chiral thiourea derivatives. Chinese J. Chem., 27: 593-601.