Discovery of novel thiourea derivatives as potent and selective β3-adrenergic receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5510-5519

  Maruyama, Tatsuya ^a   Seki, Norio ^a   Onda, Kenichi ^a   Suzuki, Takayuki ^a   Kawazoe, Souichirou ^a   Hayakawa, Masahiko ^a   Matsui, Tetsuo ^a   Takasu, Toshiyuki ^a   Ohta, Mitsuaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

3 Adrenergic receptor; Agonist; Diabetes; Phenoxypropanolamine; Thiourea

Indexed keywords

3 METHOXYPHENYLTHIOUREA; 4 NITROPHENYLTHIOUREA; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY;

ADRENERGIC AGONISTS; ADRENERGIC BETA-3 RECEPTOR ANTAGONISTS; ANIMALS; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; MICE; MOLECULAR STRUCTURE; OBESITY; PHENOXYPROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-3; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

RODENTIA;

EID: 67651087375     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.031     Document Type: Article

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