Determination of the influence of primary drying rates on the microscale structural attributes and physicochemical properties of protein containing lyophilized products

Journal of Pharmaceutical Sciences

Volumn 99, Issue 11, 2010, Pages 4616-4629

  Parker, Andrew ^a   Rigby Singleton, Shellie ^a   Perkins, Mark ^a   Bates, David ^a   Le Roux, Delphine ^a   Roberts, Clive J ^a   Madden Smith, Claire ^a   Lewis, Lavinia ^b   Teagarden, Dirk L ^b   Johnson, Robert E ^b   Ahmed, Saleem S ^b  

^a Molecular Profiles Ltd   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Bovine serum albumin; Lyophilization; Micro X ray computed tomography; Microcollapse; Primary drying

Indexed keywords

BOVINE SERUM ALBUMIN;

ARTICLE; FREEZE DRYING; INFRARED SPECTROSCOPY; MICRO-COMPUTED TOMOGRAPHY; PHYSICAL CHEMISTRY; POROSITY; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; REACTION TIME; SCANNING ELECTRON MICROSCOPY; TEMPERATURE MEASUREMENT;

EID: 78149293677     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22185     Document Type: Article

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