Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice

Journal of Gastroenterology and Hepatology (Australia)

Volumn 25, Issue 11, 2010, Pages 1769-1776

  Park, Jin Kyu ^a   Hong, Il Hwa ^a   Ki, Mi Ran ^a   Chung, Hae Young ^b   Ishigami, Akihito ^d   Ji, Ae Ri ^a   Goo, Moon Jung ^a   Kim, Dong Hwan ^a   Kwak, Ji Hoon ^a   Min, Chang Woo ^a   Lee, Seung Sook ^c   Jeong, Kyu Shik ^a  

^a Kyungpook National University   (South Korea)

^b Pusan National University   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

^d TOHO UNIVERSITY   (Japan)

Author keywords

Binucleation; CYP2E1; ROS; SMP30; Vitamin C

Indexed keywords

ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CYCLINE; CYTOCHROME P450 2E1; DRINKING WATER; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; REGUCALCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCORBIC ACID DEFICIENCY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMISTRY; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TREATMENT DURATION; UPREGULATION; WEIGHT REDUCTION; WILD TYPE;

EID: 78149276657     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2010.06239.x     Document Type: Article

References (33)

1. Fujita T, Uchida K, Maruyama N. Purification of senescence marker protein- 30 (SMP30) and its androgen- independent decrease with age in the rat liver. Biochim. Biophys. Acta 1992; 1116: 122-8.
2. Mori T, Ishigami A, Seyama K et al. Senescence marker protein- 30 knockout mouse as a novel murine model of senile lung. Pathol. Int. 2004; 54: 167-73.
3. Ishigami A, Fujita T, Handa S et al. Senescence marker protein- 30 knockout mouse liver is highly susceptible to tumor necrosis factor- alpha- and Fas- mediated apoptosis. Am. J. Pathol. 2002; 161: 1273-81.
4. Yumura W, Imasawa T, Suganuma S et al. Accelerated tubular cell senescence in SMP30 knockout mice. Histol. Histopathol. 2006; 21: 1151-6.
5. Sato T, Seyama K, Sato Y et al. Senescence marker protein- 30 protects mice lungs from oxidative stress, aging, and smoking. Am. J. Respir. Crit. Care. Med. 2006; 174: 530-7.
6. Son TG, Zou Y, Jung KJ et al. SMP30 deficiency causes increased oxidative stress in brain. Mech. Ageing Dev. 2006; 127: 451-7.
7. Kondo Y, Sasaki T, Sato Y et al. Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice. Biochem. Biophys. Res. Commun. 2008; 377: 291-6.
8. Kondo Y, Inai Y, Sato Y et al. Senescence marker protein 30 functions as gluconolactonase in l- ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc. Natl. Acad. Sci. USA 2006; 103: 5723-8.
9. Buettner GR. The pecking order of free radicals and antioxidants: lipid peroxidation, alpha- tocopherol, and ascorbate. Arch. Biochem. Biophys. 1993; 300: 535-43.
10. Buettner GR, Jurkiewicz BA. Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiat. Res. 1996; 145: 532-41.
11. Lykkesfeldt J, Moos T. Age- dependent change in Vitamin C status: a phenomenon of maturation rather than of ageing. Mech. Ageing Dev. 2005; 126: 892-8.
12. Nishikimi M, Yagi K. Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis. Am. J. Clin. Nutr. 1991; 54: 1203S-8S.
13. Zhang S, Cawley GF, Eyer CS, Backes WL. Altered ethylbenzene- mediated hepatic CYP2E1 expression in growth hormone- deficient dwarf rats. Toxicol. Appl. Pharmacol. 2002; 179: 74-82.
14. Videla LA, Rodrigo R, Orellana M et al. Oxidative stress- related parameters in the liver of non- alcoholic fatty liver disease patients. Clin. Sci. (Lond) 2004; 106: 261-8.
15. Wauthier V, Schenten V, Verbeeck RK, Calderon PB. Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats. Life Sci. 2006; 79: 1913-20.
16. Scacchi M, Pincelli AI, Cavagnini F. Growth hormone in obesity. Int. J. Obes. Relat. Metab. Disord. 1999; 23: 260-71.
17. Lee ZS, Chan JC, Yeung VT et al. Plasma insulin, growth hormone, cortisol, and central obesity among young Chinese type 2 diabetic patients. Diab. Care 1999; 22: 1450-7.
18. Dees WL, Dissen GA, Hiney JK, Lara F, Ojeda SR. Alcohol ingestion inhibits the increased secretion of puberty- related hormones in the developing female rhesus monkey. Endocrinology 2000; 141: 1325-31.
19. Hamilton ML, Remmen HV, Drake JA et al. Does oxidative damage to DNA increase with age? Proc Natl. Acad. Sci. USA 2001; 98: 10469-74.
20. Schmucker DL. Age- related changes in liver structure and function: implications for disease? Exp. Gerontol. 2005; 40: 650-9.
21. Ishigami A, Kondo Y, Nanba R et al. SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span. Biochem. Biophys. Res. Commun. 2004; 315: 575-80.
22. Park JK, Jeong DH, Park HY et al. Hepatoprotective effect of Arazyme on CCl4- induced acute hepatic injury in SMP30 knock- out mice. Toxicology 2008; 246: 132-42.
23. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein- dye binding. Anal. Biochem. 2007; 72: 248-54.
24. Jung KJ, Lee EK, Yu BP, Chung HY. Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF- kappaB signaling in the inflammatory process and aging. Free. Radic. Biol. Med. 2009; 47: 983-91, doi 10.1016/j.freeradbiomed.2009.07.009.
25. Seglen PO. DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival. Cell. Biol. Toxicol. 1997; 13: 301-15.
26. Gómez- Lechón MJ, Barberá E, Gil R, Báguena J. Evolutive changes of ploidy and polynucleation in adult rat hepatocytes in culture. Cell Mol. Biol. Incl. Cyto Enzymol. 1981; 27: 695-701.
27. Toyoda H, Bregerie O, Vallet A et al. Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis. Gut 2005; 54: 297-302.
28. Nadal C, Zajdela F. Hepatic polyploidy in the rat. IV. Experimental changes in the nucleolar volume of liver cells and their mechanisms of regulation. Exp. Cell. Res. 1967; 48: 518-28.
29. Saeter G, Schwarze E, Seglen O. Shift from polyploidizing to nonpolyploidizing growth in carcinogen- treated rat liver. J. Natl. Cancer Inst. 1988; 80: 950-8.
30. Gorla GR, Malhi H, Gupta S. Polyploidy associated with oxidative injury attenuates proliferative potential of cells. J. Cell. Sci. 2001; 114: 2943-51.
31. Nakatani T, Inouye M, Mirochnitchenko O. Overexpression of antioxidant enzymes in transgenic mice decreases cellular ploidy during liver regeneration. Exp. Cell. Res. 1997; 236: 137-46.
32. Zhu X, Siedlak SL, Wang Y et al. Neuronal binucleation in Alzheimer disease hippocampus. Neuropathol. Appl. Neurobiol. 2008; 34: 457-65.
33. Rao PS, Dalu A, Kulkarni SG, Mehendale HM. Stimulated tissue repair prevents lethality in isopropanol- induced potentiation of carbon tetrachloride hepatotoxicity. Toxicol. Appl. Pharmacol. 1996; 140: 235-44.